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The map label for this gene is hemX [H]

Identifier: 29143687

GI number: 29143687

Start: 3462340

End: 3463509

Strand: Direct

Name: hemX [H]

Synonym: t3361

Alternate gene names: 29143687

Gene position: 3462340-3463509 (Clockwise)

Preceding gene: 29143686

Following gene: 29143688

Centisome position: 72.25

GC content: 55.56

Gene sequence:

>1170_bases
ATGACGGAACAAGAAAAATCCTCCGCCGTGGTTGATGAGACCAGGGAGACCGTGGAAACCACGCCACAGCCAGTTAATAC
CGAGAAAAAAAGTAAGAACGGCGCCGCGCTGGTATTAAGCGCGGTGGCGATCGCGATTGCCCTGGCGGCAGGTATTGGGC
TTTATGGCTGGGGAAAACAGCAGGCAACCGCGCAAACGGAAACCAGCGATGCGCTGGCGACGCAACTGACCGCCTTGCAA
AAGGCGCAGGAGAGCCAAAAAGCGGAGCTGGAAGGGATTATCAAAAAACAAGCGGCGCAGTTAGATGACGCGAATCGCCA
ACAGGCGGCGCTGGCGAAACAGCTTGATGAAGTACAACAAAAAGTCGCCACCATTTCCGGCAGCGATGCTAAAACCTGGC
TGCTGGCACAGGCTGATTTCCTGGTGAAACTCGCCGGACGCAAGCTGTGGAGTGATCAGGACGTCACTACCGCCGCTGCG
CTGCTCAAAAGCGCTGACGCCAGTCTGGCGGATATGAATGACCCCAGCCTGATTACCGCACGACGCGCGATTACTGACGA
TATAGCCAGCCTGTCATCCGTTGCGCAGATCGACTACGACGGCATTATTCTCAAGCTCAATCAGCTCTCTAACCAAATTG
ATAACCTGCGTCTGGCGGATAACGATACCGATGGTTCGCCGATGGATTCTGACAGCAGCGAGCTGTCCAGCTCGCTAAGC
GAATGGCGCGTTAACCTGCAAAAAAGCTGGCAGAACTTTATGGACAGCTTTATTACCATTCGCCGCCGCGATGATACCGC
CGTACCGCTGTTGGCGCCCAACCAGGACGTCTATTTACGCGAAAATATTCGCTCCCGCCTGTTAGTCGCCGCGCAGGCCG
TGCCACGCCATCAGGAAGAAACATACCGTCAGGCGCTGGATAACGTTTCGACCTGGGTTCGCGCTTATTACGATACTGAC
GACGCCGCGACAAAAGCCTTCCTGGAGGAGGTCGATAAATTAAGCCAGCAAAATATCACGATGGATCTGCCGGAAACTCT
GGGAAGCCAGGCGATTCTTGAAAAACTGATGCAAACCCGCGTGCGTAATCTGCTGGCGCAACCGACAGTCTCTACGGCAG
CGCCTGCCACGCAGACAGACGCTCCGGCAGCCGCGCCGCAAGGAGAATAA

Upstream 100 bases:

>100_bases
CGCCCGGGAACTGGGCTGGCAAGATATTAAGGTCGCTGATAACGCCGACAACGATGCGCTGTTGCGCGCATTACAATAAC
TCTCATAATGGGATGCCATA

Downstream 100 bases:

>100_bases
TGATGCTAAAAGTATTATTGCTCTTTGTGTTGTTGCTCGCGGGTATCGTGGTCGGCCCGATGATAGCCGGTCACCAGGGC
TATGTGTTAATCCAGACCGA

Product: uroporphyrinogen III C-methyltransferase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTEQEKSSAVVDETRETVETTPQPVNTEKKSKNGAALVLSAVAIAIALAAGIGLYGWGKQQATAQTETSDALATQLTALQ
KAQESQKAELEGIIKKQAAQLDDANRQQAALAKQLDEVQQKVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDVTTAAA
LLKSADASLADMNDPSLITARRAITDDIASLSSVAQIDYDGIILKLNQLSNQIDNLRLADNDTDGSPMDSDSSELSSSLS
EWRVNLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDVYLRENIRSRLLVAAQAVPRHQEETYRQALDNVSTWVRAYYDTD
DAATKAFLEEVDKLSQQNITMDLPETLGSQAILEKLMQTRVRNLLAQPTVSTAAPATQTDAPAAAPQGE

Sequences:

>Translated_389_residues
MTEQEKSSAVVDETRETVETTPQPVNTEKKSKNGAALVLSAVAIAIALAAGIGLYGWGKQQATAQTETSDALATQLTALQ
KAQESQKAELEGIIKKQAAQLDDANRQQAALAKQLDEVQQKVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDVTTAAA
LLKSADASLADMNDPSLITARRAITDDIASLSSVAQIDYDGIILKLNQLSNQIDNLRLADNDTDGSPMDSDSSELSSSLS
EWRVNLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDVYLRENIRSRLLVAAQAVPRHQEETYRQALDNVSTWVRAYYDTD
DAATKAFLEEVDKLSQQNITMDLPETLGSQAILEKLMQTRVRNLLAQPTVSTAAPATQTDAPAAAPQGE
>Mature_388_residues
TEQEKSSAVVDETRETVETTPQPVNTEKKSKNGAALVLSAVAIAIALAAGIGLYGWGKQQATAQTETSDALATQLTALQK
AQESQKAELEGIIKKQAAQLDDANRQQAALAKQLDEVQQKVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDVTTAAAL
LKSADASLADMNDPSLITARRAITDDIASLSSVAQIDYDGIILKLNQLSNQIDNLRLADNDTDGSPMDSDSSELSSSLSE
WRVNLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDVYLRENIRSRLLVAAQAVPRHQEETYRQALDNVSTWVRAYYDTDD
AATKAFLEEVDKLSQQNITMDLPETLGSQAILEKLMQTRVRNLLAQPTVSTAAPATQTDAPAAAPQGE

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=393, Percent_Identity=87.7862595419847, Blast_Score=663, Evalue=0.0,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 42300; Mature: 42168

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQEKSSAVVDETRETVETTPQPVNTEKKSKNGAALVLSAVAIAIALAAGIGLYGWGKQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
QATAQTETSDALATQLTALQKAQESQKAELEGIIKKQAAQLDDANRQQAALAKQLDEVQQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDVTTAAALLKSADASLADMNDPSLITA
HHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCHHHH
RRAITDDIASLSSVAQIDYDGIILKLNQLSNQIDNLRLADNDTDGSPMDSDSSELSSSLS
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHH
EWRVNLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDVYLRENIRSRLLVAAQAVPRHQEE
HHHHHHHHHHHHHHHHHHEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCHHHH
TYRQALDNVSTWVRAYYDTDDAATKAFLEEVDKLSQQNITMDLPETLGSQAILEKLMQTR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEECHHHHCHHHHHHHHHHHH
VRNLLAQPTVSTAAPATQTDAPAAAPQGE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEQEKSSAVVDETRETVETTPQPVNTEKKSKNGAALVLSAVAIAIALAAGIGLYGWGKQ
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
QATAQTETSDALATQLTALQKAQESQKAELEGIIKKQAAQLDDANRQQAALAKQLDEVQQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KVATISGSDAKTWLLAQADFLVKLAGRKLWSDQDVTTAAALLKSADASLADMNDPSLITA
HHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCHHHH
RRAITDDIASLSSVAQIDYDGIILKLNQLSNQIDNLRLADNDTDGSPMDSDSSELSSSLS
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHH
EWRVNLQKSWQNFMDSFITIRRRDDTAVPLLAPNQDVYLRENIRSRLLVAAQAVPRHQEE
HHHHHHHHHHHHHHHHHHEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCHHHH
TYRQALDNVSTWVRAYYDTDDAATKAFLEEVDKLSQQNITMDLPETLGSQAILEKLMQTR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEECHHHHCHHHHHHHHHHHH
VRNLLAQPTVSTAAPATQTDAPAAAPQGE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]