Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 29143685

GI number: 29143685

Start: 3460640

End: 3461581

Strand: Direct

Name: hemC [H]

Synonym: t3359

Alternate gene names: 29143685

Gene position: 3460640-3461581 (Clockwise)

Preceding gene: 29143680

Following gene: 29143686

Centisome position: 72.22

GC content: 58.49

Gene sequence:

>942_bases
ATGTTAGACAATGTTTTAAGAATTGCCACACGCCAAAGTCCCCTTGCGCTTTGGCAGGCACATTATGTCAAAGACGCATT
GATGGCAACCCATCCGGGACTGACGGTAGAACTGGTGCCGATGGTCACACGCGGCGACGTGATTCTCGATACTCCCCTGG
CGAAAGTGGGCGGTAAGGGACTGTTTGTTAAAGAGCTTGAAATCGCGCTGCTGGAAAAACGCGCTGATATCGCCGTGCAC
TCTATGAAAGACGTTCCGGTGGCCTTCCCGGACGGTCTCGGTCTGGTGACCATTTGCGAGCGCGAAGATCCGCGCGACGC
GTTTGTCTCGAATAAATATCACAGTCTGGACGATCTGCCCGCGGGTAGTATCGTCGGGACGTCCAGTTTGCGTCGTCAGT
GTCAACTGGCGGAACGCCGTCCGGATCTCATTATCCGTTCGTTGCGCGGCAACGTCGGCACACGTCTCGGCAAGCTGGAT
AACGGCGACTATGACGCCATTATCCTGGCCGTGGCCGGTCTGAAACGCTTAGGTCTGGAGTCGCGCATTCGCACAGCCTT
GCCGCCTGACGTTTCGCTTCCTGCCGTAGGCCAGGGCGCTGTCGGGATTGAGTGTCGTCTTGACGACGCGCGAACACAGG
CGCTGCTCGCACCGTTGAATCACTCGCAAACCGCGCTGCGCGTAACGGCGGAACGTGCTATGAACACCCGCCTGGAAGGC
GGTTGTCAGGTGCCGATTGGCAGCTATGCAGAAATCATCAACGGTGAAATTTGGCTACGCGCGCTGGTTGGCGCGCCGGA
CGGTTCGGTGATGGTGCGCGGCGAACGTCGTGGTTCTCCCGAGCAGGCGGAGCAAATGGGCATCTCGCTTGCAGAGGAAC
TGCTGGAAAACGGCGCGCGCGCGATTCTGACGGAAGTTTATAACGGCGAGACGCCCGCATGA

Upstream 100 bases:

>100_bases
GACACTGCGCCTTATCCTCTCACTCACGGTGACCGGAAAACTAACATACTCTCTATAAGGATGTTAGGATGGTCAATGAT
TGATAATGACGGTAACAAGC

Downstream 100 bases:

>100_bases
GTATTCTGATCACCCGCCCCTCTCCCGCAGGGGAAGCGTTAGTGAGCCGTCTGCGCGCACTGGGGCAGGTGGCCTGGAGT
TTTCCACTGATTGAATTTGT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKGLFVKELEIALLEKRADIAVH
SMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLD
NGDYDAIILAVAGLKRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG
GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGARAILTEVYNGETPA

Sequences:

>Translated_313_residues
MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKGLFVKELEIALLEKRADIAVH
SMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLD
NGDYDAIILAVAGLKRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG
GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGARAILTEVYNGETPA
>Mature_313_residues
MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKGLFVKELEIALLEKRADIAVH
SMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLD
NGDYDAIILAVAGLKRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG
GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGARAILTEVYNGETPA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=42.1686746987952, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=42.1686746987952, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI48994974, Length=313, Percent_Identity=89.1373801916933, Blast_Score=566, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319996, Length=318, Percent_Identity=40.251572327044, Blast_Score=198, Evalue=9e-52,
Organism=Drosophila melanogaster, GI20130425, Length=312, Percent_Identity=39.1025641025641, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33714; Mature: 33714

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEECCHHHHCCCC
LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP
EEHHHHHHHHHHHHHHHEEECCCCCCEECCCCCCEEEEECCCCCHHHHHCCCCCCCCCCC
AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE
CCCEECCHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCHH
SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG
HHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHHHHEECCCCCCHHHHEEHHHHHHHHCCC
GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR
CCCCCCCHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCHH
AILTEVYNGETPA
EEHHHHHCCCCCC
>Mature Secondary Structure
MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKG
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEECCHHHHCCCC
LFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLP
EEHHHHHHHHHHHHHHHEEECCCCCCEECCCCCCEEEEECCCCCHHHHHCCCCCCCCCCC
AGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLE
CCCEECCHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCHH
SRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEG
HHHHHCCCCCCCCCCCCCCCEEEEEEECCHHHHHHEECCCCCCHHHHEEHHHHHHHHCCC
GCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGAR
CCCCCCCHHHHHHCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCHH
AILTEVYNGETPA
EEHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA