| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is metE [H]
Identifier: 29143658
GI number: 29143658
Start: 3433125
End: 3435389
Strand: Reverse
Name: metE [H]
Synonym: t3332
Alternate gene names: 29143658
Gene position: 3435389-3433125 (Counterclockwise)
Preceding gene: 29143660
Following gene: 29143657
Centisome position: 71.69
GC content: 57.57
Gene sequence:
>2265_bases ATGACAATATTGACTCATACCCTCGGTTTTCCTCGCGTTGGCCTGCGTCGCGAGTTGAAAAAAGCGCAAGAGAGCTACTG GGCGGGGAACACAACGCGTGAAGCGTTACTGGCGGTGGGCCGCGAACTGCGCGCGCGTCACTGGGAGCAGCAGAAACAAG CGGGTATTGACCTGTTACCGGTAGGCGACTTTGCCTGGTACGACCATGTTCTGACCACCAGCCTGCTGTTAGGCAATGTG CCGGCTCGTCATCAGAACAACGACGGTTCCGTGGACATCGACACTCTGTTCCGCATTGGCCGTGGTCGCGCGCCAACCGG CGAACCGGCGGCGGCAGCGGAAATGACCAAATGGTTTAATACTAACTATCACTACATAGTACCGGAGTTCAGCAAAGGCC AGCAGTTCAGGCTTACCTGGACACAGTTGCTGGAGGAAGTGGACGAAGCGCTGGCGCTGGGGCATAAGATCAAACCCGTA CTGCTGGGGCCTGTCACGTATCTGTGGCTGGGTAAAGTGAAAGGCGAGCCGTTTGACCGCCTGACGTTGCTGAAAGACAT TTTGCCGGTGTATCAGCACGTGCTGGCTGAGCTGGCGAAGCGTGGTGTTGAGTGGGTCCAAATTGATGAGCCAGCACTGG TGCTGGAACTGCCGCAGGCGTGGCTGGATGCCTTCAAACCGGCTTACGACGCGCTCGCCGGCCAGGTGAAGCTGTTGCTG ACGACCTATTTTGAAGGCGTGACGCCAAACCTGGACACTATTATCGTGCTACCGGTACAGGGGCTACATGTTGACCTCAT TCATGGCAAAGATGATGTAGTGGAACTGCATCAACGTCTGCCGGTCGACTGGCTGCTCTCCGCAGGCTTGATTAACGGGC GTAATGTCTGGCGCGCCGATTTGACCGAAAAATACGCGCAGATTAACGCCATTGTGGGCAAACGCGCGCTGTGGGTAGCA TCCTCCTGCTCTTTACTGCACAGCCCGATCGATCTCAGCGTCGAAACGCGTCTGGATACGGAAGTAAAAAGCTGGTTTGC CTTTGCGCTGCAAAAATGCGGTGAACTGGCGTTGCTGCGCGATGCGCTGAACAGCGGCGAAACGGCGGCGCTTGAGGAAT GGAGCGTACCGATTCAGGCTCGTCGTCACTCCCATCGCGTACATAATGCCGCAGTAGAAAAACGCCTGGCGGCGATCACC GCGCAGGACAGCCAGCGTGAGAATCCGTATGAGGTGCGCGCTGAAGCGCAACGCGCCCGCTTTAAACTTCCCGCCTGGCC GACGACGACTATCGGTTCGTTTCCGCAAACCACGGAAATTCGCGGCCTGCGTCTGGACTTCAAAAAGGGCAACCTCGACG CGAACAACTACCGCACCGGCATCGCCGAACATATCAAACAGGCTATCATCGAGCAGGAGCGTTTAGGGCTGGATGTGCTG GTACACGGCGAAGCCGAGCGAAACGACATGGTGGAATACTTCGGCGAGCATCTGGACGGCTTCGTCTTTACCCAGAATGG TTGGGTGCAAAGCTATGGCTCCCGCTGTGTGAAACCGCCGGTAGTGATTGGCGATATCAGCCGTCCGGCACCGATTACCG TGGAGTGGGCGAAATATGCCCAGTCGCTGACCGACAAGCCGGTAAAAGGGATGTTGACCGGCCCGGTGACTATTCTTTGC TGGTCATTCCCCCGCGAAGACGTGACCCGCGAAACGATTGCGAAACAGATTGCGCTGGCGCTGCGTGATGAAGTCGCGGA TCTGGAGGCGGCGGGGATCGGGATTATTCAGATTGACGAACCGGCGCTGCGTGAAGGTTTACCGCTGCGTCGCAGCGACT GGGACGCCTATCTGGAATGGGGTGTGGAAGCCTTCCGCATCAACGCGGCGGTGGCGAAGGATGAAACCCAGATCCACACC CACATGTGTTACTGCGAGTTCAACGACATTATGGATTCGATCGCCGCGCTGGACGCGGATGTGATCACCATTGAGACCTC CCGCTCGGATATGGAGTTGCTGGAGTCGTTCGAAGCGTTCGACTACCCGAACGAAATCGGGCCGGGCGTGTACGATATTC ACTCGCCGAACGTGCCGAGCGTCGAGTGGATTGAAGCCCTGCTGAAGAAGGCGGCACAACGTATTCCGGCACAACGCCTG TGGGTGAATCCGGACTGCGGTCTGAAAACTCGCGGTTGGCCGGAAACCCGCGCGGCGTTAGCGAACATGGTCAAAGCGGC GCACAATCTGCGTCAGGCGAAATAA
Upstream 100 bases:
>100_bases TTCAGTAAGCTCCTGGGGATGCGCTGTGTCGCCGCCTTCCTGCAAGCCGAACTATTTAGAGTTTTACTTTCAGATTCAAT AAAATAAGAGAGGAAGTAAA
Downstream 100 bases:
>100_bases CCCATCCTGACCGCTGCGTTTATCCGGCAGCAATGCGGCGCTACCCTTTGACGGGTAGCGCCCGTGTCTGACCTGATTAA CAGCGCCTCTTTCTTCTCAT
Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
Products: NA
Alternate protein names: Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme [H]
Number of amino acids: Translated: 754; Mature: 753
Protein sequence:
>754_residues MTILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNV PARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPV LLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGVEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL TTYFEGVTPNLDTIIVLPVQGLHVDLIHGKDDVVELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVA SSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSVPIQARRHSHRVHNAAVEKRLAAIT AQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILC WSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHT HMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK
Sequences:
>Translated_754_residues MTILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNV PARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPV LLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGVEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL TTYFEGVTPNLDTIIVLPVQGLHVDLIHGKDDVVELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVA SSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSVPIQARRHSHRVHNAAVEKRLAAIT AQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILC WSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHT HMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK >Mature_753_residues TILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVP ARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVL LGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGVEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLLT TYFEGVTPNLDTIIVLPVQGLHVDLIHGKDDVVELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVAS SCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSVPIQARRHSHRVHNAAVEKRLAAITA QDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVLV HGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCW SFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTH MCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRLW VNPDCGLKTRGWPETRAALANMVKAAHNLRQAK
Specific function: Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation [H]
COG id: COG0620
COG function: function code E; Methionine synthase II (cobalamin-independent)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the vitamin-B12 independent methionine synthase family [H]
Homologues:
Organism=Escherichia coli, GI2367304, Length=753, Percent_Identity=93.4926958831341, Blast_Score=1458, Evalue=0.0, Organism=Saccharomyces cerevisiae, GI6320936, Length=767, Percent_Identity=48.109517601043, Blast_Score=711, Evalue=0.0,
Paralogues:
None
Copy number: 45,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013215 - InterPro: IPR006276 - InterPro: IPR002629 [H]
Pfam domain/function: PF08267 Meth_synt_1; PF01717 Meth_synt_2 [H]
EC number: =2.1.1.14 [H]
Molecular weight: Translated: 84697; Mature: 84565
Theoretical pI: Translated: 5.91; Mature: 5.91
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 0.9 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLP CEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE VGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHC TNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDR CCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCHHHHEECCCCCCCHHH LTLLKDILPVYQHVLAELAKRGVEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH TTYFEGVTPNLDTIIVLPVQGLHVDLIHGKDDVVELHQRLPVDWLLSAGLINGRNVWRAD HHHHCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCEEHHH LTEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLR HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHCHHHHHH DALNSGETAALEEWSVPIQARRHSHRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRAR HHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC FKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL EECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYA EECCCCHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCCCEEEECCCCCCCCEEHHHHHH QSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDE HHHCCCCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC PALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDAD HHHHCCCCCCCCCHHHHHHHCCHHEEEEHHHCCCCCEEEHEEEEEEHHHHHHHHHHCCCC VITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL EEEEECCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCHHHE WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure TILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLP EEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE VGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFN CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHC TNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDR CCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCHHHHEECCCCCCCHHH LTLLKDILPVYQHVLAELAKRGVEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLL HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH TTYFEGVTPNLDTIIVLPVQGLHVDLIHGKDDVVELHQRLPVDWLLSAGLINGRNVWRAD HHHHCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCEEHHH LTEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLR HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHCHHHHHH DALNSGETAALEEWSVPIQARRHSHRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRAR HHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC FKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVL EECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEE VHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYA EECCCCHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCCCEEEECCCCCCCCEEHHHHHH QSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDE HHHCCCCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC PALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDAD HHHHCCCCCCCCCHHHHHHHCCHHEEEEHHHCCCCCEEEHEEEEEEHHHHHHHHHHCCCC VITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRL EEEEECCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCHHHE WVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA