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The map label for this gene is tatD [H]

Identifier: 29143647

GI number: 29143647

Start: 3422245

End: 3423027

Strand: Reverse

Name: tatD [H]

Synonym: t3321

Alternate gene names: 29143647

Gene position: 3423027-3422245 (Counterclockwise)

Preceding gene: 29143648

Following gene: 29143645

Centisome position: 71.43

GC content: 54.15

Gene sequence:

>783_bases
ATGTTTGATATTGGCGTTAATTTAACCAGTAGCCAGTTTGCAAAAGATCGTGATGATGTGGTCGCCCGTGCGTTTGCGGC
AGGAGTAAAAGGTATGCTACTGACCGGAACGAACATCCATGAAAGTCAGCAGGCGTTAAAACTGGCGCGGCGCTACCCCC
ATTGTTGGTCGACGGCTGGCGTCCATCCCCATGACAGCAGTCAGTGGTCATCTGCGTCTGAAGACGCCATTATTGCGCTG
GCGAACCAGCCGGAAGTCGTCGCTATCGGTGAGTGCGGGCTGGATTTCAATCGCAATTTTTCCACGCCGCAGGAGCAGGA
GCGTGCCTTTCAGGCGCAGCTACAAATTGCCGCCGAATTGCAGATGCCAATCTTTATGCACTGCCGGGACGCGCATGAGC
GATTTCTGGCATTGCTTGATCCCTGGCTGGATAGTCTTCCTGGTGCAATACTGCACTGCTTTACCGGTTCACGCCAGCAA
ATGCAGGCCTGTGTGGACAGAGGGCTCTATATCGGTATTACCGGGTGGGTTTGCGACGAACGACGCGGGCTTGAGCTACG
TGAACTCTTACCGTTTATTCCAGCGGAAAAGCTACTGATAGAAACCGACGCGCCGTATCTGTTGCCCCGCGATCTTACGC
CGAAACCAACGTCACGACGCAACGAGCCCGCATATCTGCCTCACATCCTGGAGCGCATAGCGCTATGGCGTGGTGAAGAT
CCGCAATGGTTAGCGGCGATGACAGATGCCAATGCCAGAACCTTATTTGAGGTCGTATTCTGA

Upstream 100 bases:

>100_bases
GGACGCGCGACGAAGATAACGAGGCCGAGACCGAAAAGGCCGAGCACACTGAAGACTAAACACAACCGCCCGCCAGGGCG
GTTGTCATATGGGGGCAAGC

Downstream 100 bases:

>100_bases
ACGATCGCTAAATCTTGCGAAAACCGGTGTTTTTTACGCTCTGCTTCACTTCTTTATTGAGTAAATTAAGCAGTAACATC
GAACGCGTTTCGCCATCCGG

Product: DNase TatD

Products: NA

Alternate protein names: DNase tatD [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MFDIGVNLTSSQFAKDRDDVVARAFAAGVKGMLLTGTNIHESQQALKLARRYPHCWSTAGVHPHDSSQWSSASEDAIIAL
ANQPEVVAIGECGLDFNRNFSTPQEQERAFQAQLQIAAELQMPIFMHCRDAHERFLALLDPWLDSLPGAILHCFTGSRQQ
MQACVDRGLYIGITGWVCDERRGLELRELLPFIPAEKLLIETDAPYLLPRDLTPKPTSRRNEPAYLPHILERIALWRGED
PQWLAAMTDANARTLFEVVF

Sequences:

>Translated_260_residues
MFDIGVNLTSSQFAKDRDDVVARAFAAGVKGMLLTGTNIHESQQALKLARRYPHCWSTAGVHPHDSSQWSSASEDAIIAL
ANQPEVVAIGECGLDFNRNFSTPQEQERAFQAQLQIAAELQMPIFMHCRDAHERFLALLDPWLDSLPGAILHCFTGSRQQ
MQACVDRGLYIGITGWVCDERRGLELRELLPFIPAEKLLIETDAPYLLPRDLTPKPTSRRNEPAYLPHILERIALWRGED
PQWLAAMTDANARTLFEVVF
>Mature_260_residues
MFDIGVNLTSSQFAKDRDDVVARAFAAGVKGMLLTGTNIHESQQALKLARRYPHCWSTAGVHPHDSSQWSSASEDAIIAL
ANQPEVVAIGECGLDFNRNFSTPQEQERAFQAQLQIAAELQMPIFMHCRDAHERFLALLDPWLDSLPGAILHCFTGSRQQ
MQACVDRGLYIGITGWVCDERRGLELRELLPFIPAEKLLIETDAPYLLPRDLTPKPTSRRNEPAYLPHILERIALWRGED
PQWLAAMTDANARTLFEVVF

Specific function: Shows DNase activity [H]

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI14042943, Length=291, Percent_Identity=34.020618556701, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI225903439, Length=249, Percent_Identity=33.7349397590361, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI225903424, Length=182, Percent_Identity=34.6153846153846, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI110349730, Length=269, Percent_Identity=27.1375464684015, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI226061853, Length=273, Percent_Identity=27.1062271062271, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI110349734, Length=269, Percent_Identity=27.5092936802974, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI48994985, Length=260, Percent_Identity=81.9230769230769, Blast_Score=456, Evalue=1e-130,
Organism=Escherichia coli, GI1787342, Length=251, Percent_Identity=33.0677290836653, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082439, Length=248, Percent_Identity=29.0322580645161, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559024, Length=280, Percent_Identity=37.5, Blast_Score=200, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71980746, Length=267, Percent_Identity=24.3445692883895, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17565396, Length=168, Percent_Identity=31.547619047619, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17543026, Length=171, Percent_Identity=28.0701754385965, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648690, Length=283, Percent_Identity=37.1024734982332, Blast_Score=180, Evalue=7e-46,
Organism=Drosophila melanogaster, GI221330018, Length=296, Percent_Identity=30.0675675675676, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24586117, Length=268, Percent_Identity=30.2238805970149, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 29252; Mature: 29252

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01090 TATD_2 ; PS01091 TATD_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDIGVNLTSSQFAKDRDDVVARAFAAGVKGMLLTGTNIHESQQALKLARRYPHCWSTAG
CEEECCCCCHHHHHCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCC
VHPHDSSQWSSASEDAIIALANQPEVVAIGECGLDFNRNFSTPQEQERAFQAQLQIAAEL
CCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QMPIFMHCRDAHERFLALLDPWLDSLPGAILHCFTGSRQQMQACVDRGLYIGITGWVCDE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHCCCHHHHHHHHHCCEEEEEEEEEECC
RRGLELRELLPFIPAEKLLIETDAPYLLPRDLTPKPTSRRNEPAYLPHILERIALWRGED
CCCCCHHHHHCCCCCCCEEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PQWLAAMTDANARTLFEVVF
CCEEEEECCCCHHHHHHCCC
>Mature Secondary Structure
MFDIGVNLTSSQFAKDRDDVVARAFAAGVKGMLLTGTNIHESQQALKLARRYPHCWSTAG
CEEECCCCCHHHHHCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCC
VHPHDSSQWSSASEDAIIALANQPEVVAIGECGLDFNRNFSTPQEQERAFQAQLQIAAEL
CCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QMPIFMHCRDAHERFLALLDPWLDSLPGAILHCFTGSRQQMQACVDRGLYIGITGWVCDE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHCCCHHHHHHHHHCCEEEEEEEEEECC
RRGLELRELLPFIPAEKLLIETDAPYLLPRDLTPKPTSRRNEPAYLPHILERIALWRGED
CCCCCHHHHHCCCCCCCEEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
PQWLAAMTDANARTLFEVVF
CCEEEEECCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584020; 9649434; 1379743; 9278503; 10747959 [H]