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The map label for this gene is pepQ [H]

Identifier: 29143640

GI number: 29143640

Start: 3412141

End: 3413472

Strand: Reverse

Name: pepQ [H]

Synonym: t3314

Alternate gene names: 29143640

Gene position: 3413472-3412141 (Counterclockwise)

Preceding gene: 29143643

Following gene: 29143639

Centisome position: 71.23

GC content: 53.6

Gene sequence:

>1332_bases
ATGGAATCACTGGCCGCGCTCTATAAAAATCATATTGTTACCTTACAAGAACGGACGCGCGATGTTCTGGCGCGCTTTAA
GCTGGATGCGTTACTTATTCATTCCGGCGAGCTTTTCAACGTCTTTCTCGACGATCACCCTTATCCGTTTAAGGTCAATC
CGCAGTTTAAAGCGTGGGTGCCGGTAACTCAGGTTCCAAATTGCTGGCTGCTGGTCGATGGCGTCAACAAACCCAAATTG
TGGTTTTATCTGCCGGTCGATTACTGGCATAACGTTGAACCGCTGCCAACGTCATTCTGGACAGAAGAAGTCGAGGTCGT
CGCCTTACCGAAAGCGGATGGCATCGGCAGCCAACTTCCTGCCGCGCGTGGCAATATCGGCTATATCGGCCCGGTTCCTG
AGCGCGCGCTACAATTGGATATCGCCGCCAGCAACATCAACCCGAAAGGTGTTATCGACTATCTGCATTACTACCGCGCC
TATAAAACGGATTATGAACTGGCCTGTATGCGCGAAGCGCAGAAAATGGCGGTGAGCGGTCATCGGGCGGCGGAAGAGGC
CTTCCGTTCCGGCATGAGCGAGTTTGACATCAACCTGGCGTACCTGACCGCCACGGGACATCGCGATACCGATGTTCCGT
ACAGCAACATTGTGGCGCTGAACGAACATGCCGCCGTGCTGCATTACACGAAACTGGATCATCAGGCACCGTCTGAAATG
CGCAGTTTCCTGCTGGATGCGGGCGCGGAATACAACGGCTACGCGGCGGATCTGACGCGGACCTGGTCGGCGAAAAGCGA
TAACGACTACGCCCACCTGGTGAAAGATGTTAACGACGAACAGTTGGCGCTGATCGCTACCATGAAGGCGGGCGTTAGCT
ATGTGGATTATCATATTCAGTTCCATCAGCGCATCGCAAAGCTGCTGCGTAAGCATCAAATCATTACCGACATGAGTGAA
GAGGCGATGGTGGAAAATGATCTCACCGGGCCGTTTATGCCGCACGGTATTGGTCATCCGTTGGGTCTGCAGGTACACGA
TGTGGCCGGGTTTATGCAGGATGATTCCGGTACGCATCTCGCCGCGCCGTCCAAATACCCGTATCTGCGCTGCACGCGTG
TGTTACAGCCGCGAATGGTGTTGACCATCGAACCGGGGATTTACTTCATCGAATCGCTGTTAGCGCCGTGGCGCGAAGGG
CCATTCAGCAAGCACTTCAACTGGCAGAAAATTGAAGCGCTCAAGCCTTTCGGCGGTATTCGCATTGAAGATAACGTGGT
CATCCACGAAAACGGCGTGGAAAACATGACGCGGGATTTAAAACTGGCGTAA

Upstream 100 bases:

>100_bases
AAGAAATGCCGATGTGATCACGCTCGGCAGAGATCACGCTCTCGTGGGGCGATGTGCTAAGATGCGGAAACTTGAGGTCA
AAAAAACAGAAGGGTAAAAA

Downstream 100 bases:

>100_bases
TGGACAGTTGGTTAATCCCTGCAGCGCCGGTCACCGTTGTTGAAGAGATCAAAAAAAGCCGCTTTATTACGCTATTGGCG
CATACCGATGGCGTAGAGGC

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRA
YKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEM
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREG
PFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTRDLKLA

Sequences:

>Translated_443_residues
MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRA
YKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEM
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREG
PFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTRDLKLA
>Mature_443_residues
MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKL
WFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRA
YKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEM
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSE
EAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREG
PFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTRDLKLA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=458, Percent_Identity=29.9126637554585, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI260593665, Length=292, Percent_Identity=34.9315068493151, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI260593663, Length=320, Percent_Identity=32.8125, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI11559925, Length=301, Percent_Identity=27.2425249169435, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=95.4853273137698, Blast_Score=889, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=330, Percent_Identity=31.2121212121212, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788728, Length=300, Percent_Identity=26.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=289, Percent_Identity=34.9480968858132, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321118, Length=286, Percent_Identity=30.4195804195804, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=303, Percent_Identity=29.7029702970297, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357079, Length=290, Percent_Identity=32.0689655172414, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19920384, Length=295, Percent_Identity=28.135593220339, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 50171; Mature: 50171

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWV
CCHHHHHHHCCEEEHHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLP
CCCCCCCEEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
AARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRAYKTDYELACMREAQKMAVSG
CCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
HRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEM
CHHHHHHHHCCCCHHCEEEEEEEECCCCCCCCCHHHEEEECCCEEEEEEECCCCCCHHHH
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQ
HHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEEEHHHCCEEEHHHHH
FHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHCEEECCCCCEE
AAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIEALKPFGGI
CCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCE
RIEDNVVIHENGVENMTRDLKLA
EEECCEEEECCCHHHHHHHCCCC
>Mature Secondary Structure
MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWV
CCHHHHHHHCCEEEHHHHHHHHHHHHHHCEEEEECCCEEEEEECCCCCCEEECCCCEEEE
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLP
CCCCCCCEEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
AARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRAYKTDYELACMREAQKMAVSG
CCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
HRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEM
CHHHHHHHHCCCCHHCEEEEEEEECCCCCCCCCHHHEEEECCCEEEEEEECCCCCCHHHH
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQ
HHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEEEHHHCCEEEHHHHH
FHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHCEEECCCCCEE
AAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIEALKPFGGI
CCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCE
RIEDNVVIHENGVENMTRDLKLA
EEECCEEEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA