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The map label for this gene is degQ [H]

Identifier: 29143597

GI number: 29143597

Start: 3354520

End: 3355887

Strand: Direct

Name: degQ [H]

Synonym: t3264

Alternate gene names: 29143597

Gene position: 3354520-3355887 (Clockwise)

Preceding gene: 29143596

Following gene: 29143598

Centisome position: 70.0

GC content: 53.95

Gene sequence:

>1368_bases
ATGAAAAAACACACCCAGCTGTTAAGTGCATTAGCGTTAAGTGTCGGATTAACTCTTTCGGCACCGTTTCCAGCCCTTGC
ATCGATACCAGGCCAGGTGCCAGGCCAGGCGACGCTGCCAAGCCTTGCCCCTATGCTGGAGAAAGTGCTGCCTGCTGTCG
TCAGCGTAAAAGTCGAGGGAACCGCCACCCAGAGCCAAAAAGTGCCGGAGGAGTTTAAAAAATTCTTTGGCGAGGATCTG
CCAGACCAGCCGTCCCAGCCGTTTGAAGGACTCGGTTCGGGGGTGATTATCGATGCCGCGAAAGGCTATGTATTAACCAA
TAATCATGTGATTAATCAGGCACAGAAGATCAGCATTCAACTGAATGACGGACGCGAATTCGACGCGAAGCTGATCGGCG
GCGACGACCAGAGCGATATCGCTCTGTTACAAATTCAGAATCCCAGCAAGTTAACGCAAATTGCCATCGCCGATTCCGAC
AAACTCCGCGTCGGCGATTTCGCCGTGGCGGTTGGTAATCCGTTTGGCCTTGGACAAACCGCCACCTCCGGGATTATTTC
AGCGCTGGGACGCAGCGGGCTTAATCTGGAAGGGCTTGAGAACTTTATTCAAACCGATGCCTCTATTAACCGCGGCAACT
CCGGCGGCGCGCTGCTTAACCTGAACGGCGAGCTGATCGGGATTAATACCGCAATCCTCGCGCCAGGGGGCGGGAGCATC
GGCATTGGCTTTGCTATTCCTTCCAATATGGCGCAGACGCTGGCGCAGCAGTTGATTCAGTTCGGCGAAATCAAACGCGG
ATTGCTGGGAATTAAAGGCACTGAAATGACCGCTGATATCGCTAAGGCATTCAAACTGAACGTTCAGCGTGGCGCTTTTG
TCAGCGAGGTTTTACCCAATTCAGGTTCGGCGAAGGCCGGGGTGAAATCCGGAGACGTGATTATCAGTCTTAACGGTAAG
CCGCTGAATAGCTTTGCCGAACTGCGTTCACGTATCGCCACCACCGAACCGGGCACGAAAGTGAAGCTGGGCCTGCTGCG
CGATGGTAAGCCGCTGGAGGTGGAAGTCACGCTGGATTCCAATACCTCTTCTTCCGCCAGCGCCGAAATGATCGCCCCGG
CGTTGCAAGGCGCGACGTTGAGCGACGGCCAGCTGAAAGACGGGACGAAAGGCGTTAAGGTTGATAGCGTCGAAAAAAGC
AGTCCTGCCGCGCAGGCCGGTTTGCAAAAAGATGATGTTATCATCGGCGTTAATCGCGATCGCATCAGTTCTATCGCCGA
AATGCGCAAAGTGATGGCGGCAAAACCGTCCATCATTGCTCTTCAGGTAGTACGCGGCAACGAGAACATTTATCTATTGC
TGCGCTAA

Upstream 100 bases:

>100_bases
CCTGTCCCAGCTATTATCATTGTTACCAGGCTGAAAATTCAATAACATCAATCTGTTTTGAATTGTCTATCCGTTCATTC
AAGGTACGAGAGCAGCATCC

Downstream 100 bases:

>100_bases
TCCTGTCTTAAACCGGGCATCAGCCTGCGATGTGATGTCCGGTTAACTCATGGTATGCTGCTGCCGTTCCCTTTTTTAAC
GACGCCTCCATCATGTTTGT

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKHTQLLSALALSVGLTLSAPFPALASIPGQVPGQATLPSLAPMLEKVLPAVVSVKVEGTATQSQKVPEEFKKFFGEDL
PDQPSQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISIQLNDGREFDAKLIGGDDQSDIALLQIQNPSKLTQIAIADSD
KLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
GIGFAIPSNMAQTLAQQLIQFGEIKRGLLGIKGTEMTADIAKAFKLNVQRGAFVSEVLPNSGSAKAGVKSGDVIISLNGK
PLNSFAELRSRIATTEPGTKVKLGLLRDGKPLEVEVTLDSNTSSSASAEMIAPALQGATLSDGQLKDGTKGVKVDSVEKS
SPAAQAGLQKDDVIIGVNRDRISSIAEMRKVMAAKPSIIALQVVRGNENIYLLLR

Sequences:

>Translated_455_residues
MKKHTQLLSALALSVGLTLSAPFPALASIPGQVPGQATLPSLAPMLEKVLPAVVSVKVEGTATQSQKVPEEFKKFFGEDL
PDQPSQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISIQLNDGREFDAKLIGGDDQSDIALLQIQNPSKLTQIAIADSD
KLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
GIGFAIPSNMAQTLAQQLIQFGEIKRGLLGIKGTEMTADIAKAFKLNVQRGAFVSEVLPNSGSAKAGVKSGDVIISLNGK
PLNSFAELRSRIATTEPGTKVKLGLLRDGKPLEVEVTLDSNTSSSASAEMIAPALQGATLSDGQLKDGTKGVKVDSVEKS
SPAAQAGLQKDDVIIGVNRDRISSIAEMRKVMAAKPSIIALQVVRGNENIYLLLR
>Mature_455_residues
MKKHTQLLSALALSVGLTLSAPFPALASIPGQVPGQATLPSLAPMLEKVLPAVVSVKVEGTATQSQKVPEEFKKFFGEDL
PDQPSQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISIQLNDGREFDAKLIGGDDQSDIALLQIQNPSKLTQIAIADSD
KLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
GIGFAIPSNMAQTLAQQLIQFGEIKRGLLGIKGTEMTADIAKAFKLNVQRGAFVSEVLPNSGSAKAGVKSGDVIISLNGK
PLNSFAELRSRIATTEPGTKVKLGLLRDGKPLEVEVTLDSNTSSSASAEMIAPALQGATLSDGQLKDGTKGVKVDSVEKS
SPAAQAGLQKDDVIIGVNRDRISSIAEMRKVMAAKPSIIALQVVRGNENIYLLLR

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=316, Percent_Identity=36.0759493670886, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4506141, Length=294, Percent_Identity=36.3945578231293, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI24308541, Length=302, Percent_Identity=30.1324503311258, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI7019477, Length=296, Percent_Identity=32.7702702702703, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1789629, Length=455, Percent_Identity=90.1098901098901, Blast_Score=801, Evalue=0.0,
Organism=Escherichia coli, GI1786356, Length=457, Percent_Identity=55.7986870897155, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1789630, Length=357, Percent_Identity=40.3361344537815, Blast_Score=217, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=32.2916666666667, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47311; Mature: 47311

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHTQLLSALALSVGLTLSAPFPALASIPGQVPGQATLPSLAPMLEKVLPAVVSVKVEG
CCHHHHHHHHHHHHHCCEECCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECC
TATQSQKVPEEFKKFFGEDLPDQPSQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISIQ
CCCCHHCCHHHHHHHHCCCCCCCCCCCHHHCCCCEEEECCCCEEEECCCEECCEEEEEEE
LNDGREFDAKLIGGDDQSDIALLQIQNPSKLTQIAIADSDKLRVGDFAVAVGNPFGLGQT
ECCCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEECCCCEEECEEEEEECCCCCCCHH
ATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCCCE
GIGFAIPSNMAQTLAQQLIQFGEIKRGLLGIKGTEMTADIAKAFKLNVQRGAFVSEVLPN
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCC
SGSAKAGVKSGDVIISLNGKPLNSFAELRSRIATTEPGTKVKLGLLRDGKPLEVEVTLDS
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECC
NTSSSASAEMIAPALQGATLSDGQLKDGTKGVKVDSVEKSSPAAQAGLQKDDVIIGVNRD
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCHHHCCCCCCCEEEECCHH
RISSIAEMRKVMAAKPSIIALQVVRGNENIYLLLR
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MKKHTQLLSALALSVGLTLSAPFPALASIPGQVPGQATLPSLAPMLEKVLPAVVSVKVEG
CCHHHHHHHHHHHHHCCEECCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECC
TATQSQKVPEEFKKFFGEDLPDQPSQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISIQ
CCCCHHCCHHHHHHHHCCCCCCCCCCCHHHCCCCEEEECCCCEEEECCCEECCEEEEEEE
LNDGREFDAKLIGGDDQSDIALLQIQNPSKLTQIAIADSDKLRVGDFAVAVGNPFGLGQT
ECCCCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEECCCCEEECEEEEEECCCCCCCHH
ATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCCCE
GIGFAIPSNMAQTLAQQLIQFGEIKRGLLGIKGTEMTADIAKAFKLNVQRGAFVSEVLPN
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCC
SGSAKAGVKSGDVIISLNGKPLNSFAELRSRIATTEPGTKVKLGLLRDGKPLEVEVTLDS
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECC
NTSSSASAEMIAPALQGATLSDGQLKDGTKGVKVDSVEKSSPAAQAGLQKDDVIIGVNRD
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCHHHCCCCCCCEEEECCHH
RISSIAEMRKVMAAKPSIIALQVVRGNENIYLLLR
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]