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The map label for this gene is gatD [H]

Identifier: 29143517

GI number: 29143517

Start: 3272968

End: 3274011

Strand: Direct

Name: gatD [H]

Synonym: t3181

Alternate gene names: 29143517

Gene position: 3272968-3274011 (Clockwise)

Preceding gene: 29143516

Following gene: 29143518

Centisome position: 68.3

GC content: 55.08

Gene sequence:

>1044_bases
ATGAAATCAGTGGTTATTCACGCTGAGGGAGACGTGCGCGTTGAAGAACGTCCCTTACCACAACTGCAAGCCGAGGACGA
TGTGTTGGTCAAAGTCGTTAGCTCAGGGCTTTGCGGGTCGGATATCCCGCGTATTTTCGCGCAGGGCGCCCATTATTATC
CTATTACGTTAGGCCATGAATTCAGCGGCTACGTTGAATCCTACGGCACAGGCGTAACGGATATGCAGCCTGGCGATGCC
GTCGCTTGTGTCCCGCTTCTTCCCTGCTTTCACTGTCCGCAATGCGAACGCGGTTACTTTTCTTTATGCAAACAGTATCA
GTTTGTAGGATCGCGCAGCGAAGGCGGTAATGCGGAATATGTGGTGGTCAAACGGGCCAATCTTTTCCGCTTGCCGTCTG
ATATGCCGATTGAAGATGGCGCGTTTATCGAACCGATTACCGTGGGCTTACACGCCTTTCATCTGGCGCAGGGCTGCGAG
GGGAAAAACGTAATTATCGTCGGGGCCGGGACAATTGGCCTGCTGGCCTTACAGTGCGCGCGGGAACTGGGCGCGCGAAG
CGTAACGGCGATTGATATCAATCCGCAGAAACTGGAACTGGCGAAAGCGCTCGGCGCAACGCATACCTGTAATAGCCGGG
AAATGACCGCCGACGACATCCAGACCGCGTTGTCCGACATTCAGTTTGATCAACTGGTTCTCGAAACGGCAGGAACTCCC
CAGACCGTCTCGCTGGCTATCGATATCACCGGGCCGCGCGCGCAACTGGCGCTGGTGGGGACGTTACATCACGATCTCAC
CCTGACGACGCGTACATTCGGGTTAATTTTGCGTAAAGAGCTCACGCTCCTCGGCAGTTGGATGAACTACTCCGCGCCAT
GGCCAGGAGAAGAATGGGAAACCGCAGCGCGCCTGTTGGCTGAAAAACGTCTTCAACTGACCCCTCTCATTGCCCATCGC
GGCGATGCGGAAAGCTTTGCAGAAGCAGTCAAAGCGCTTAATGGCGCGCCCATGCAGGGCAAAATCTTACTTCAACTTTC
CTGA

Upstream 100 bases:

>100_bases
CAGTTTGTCGCGGCTGAGAAAGCCACGGCGCTACAGCAAAGTCAAATCGCCTCTTAATTTTAGGGGAGCAATCGCTCCCC
TCACCTTCCTGGAGAATGTT

Downstream 100 bases:

>100_bases
TGGTACGAGCCAGCAACCTGCGCTGGCTCACATTTCCTTTCGAAATTTAGCGTTCACCTTTCGCAATCCTTCGTTTAAAC
TAGTTACAGTTAATTATCAG

Product: galactitol-1-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHEFSGYVESYGTGVTDMQPGDA
VACVPLLPCFHCPQCERGYFSLCKQYQFVGSRSEGGNAEYVVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCE
GKNVIIVGAGTIGLLALQCARELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSDIQFDQLVLETAGTP
QTVSLAIDITGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWETAARLLAEKRLQLTPLIAHR
GDAESFAEAVKALNGAPMQGKILLQLS

Sequences:

>Translated_347_residues
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHEFSGYVESYGTGVTDMQPGDA
VACVPLLPCFHCPQCERGYFSLCKQYQFVGSRSEGGNAEYVVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCE
GKNVIIVGAGTIGLLALQCARELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSDIQFDQLVLETAGTP
QTVSLAIDITGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWETAARLLAEKRLQLTPLIAHR
GDAESFAEAVKALNGAPMQGKILLQLS
>Mature_347_residues
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHEFSGYVESYGTGVTDMQPGDA
VACVPLLPCFHCPQCERGYFSLCKQYQFVGSRSEGGNAEYVVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCE
GKNVIIVGAGTIGLLALQCARELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSDIQFDQLVLETAGTP
QTVSLAIDITGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWETAARLLAEKRLQLTPLIAHR
GDAESFAEAVKALNGAPMQGKILLQLS

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=29.5977011494253, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI156523966, Length=350, Percent_Identity=26.2857142857143, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501939, Length=340, Percent_Identity=26.1764705882353, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501929, Length=211, Percent_Identity=27.9620853080569, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI262073058, Length=228, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71743840, Length=228, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI34577061, Length=229, Percent_Identity=27.5109170305677, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4501933, Length=229, Percent_Identity=27.9475982532751, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1788407, Length=344, Percent_Identity=68.3139534883721, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=31.9148936170213, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=27.3255813953488, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1787863, Length=336, Percent_Identity=28.8690476190476, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI226510992, Length=325, Percent_Identity=28.9230769230769, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790718, Length=360, Percent_Identity=26.9444444444444, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=25.1428571428571, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788075, Length=345, Percent_Identity=25.5072463768116, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786825, Length=311, Percent_Identity=26.3665594855305, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081918, Length=225, Percent_Identity=30.6666666666667, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786552, Length=228, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786518, Length=275, Percent_Identity=28.7272727272727, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=360, Percent_Identity=31.6666666666667, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=257, Percent_Identity=33.4630350194552, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25146526, Length=347, Percent_Identity=25.0720461095101, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=320, Percent_Identity=25.625, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=319, Percent_Identity=25.3918495297806, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=194, Percent_Identity=31.9587628865979, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=30.1775147928994, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=30.1775147928994, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=28.6532951289398, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319258, Length=234, Percent_Identity=29.4871794871795, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=314, Percent_Identity=24.203821656051, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=247, Percent_Identity=27.1255060728745, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=31.700288184438, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI17737897, Length=350, Percent_Identity=30.2857142857143, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17737895, Length=299, Percent_Identity=27.4247491638796, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550770, Length=173, Percent_Identity=28.9017341040462, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=173, Percent_Identity=28.9017341040462, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221457811, Length=173, Percent_Identity=28.9017341040462, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 37491; Mature: 37491

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHE
CCEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCC
FSGYVESYGTGVTDMQPGDAVACVPLLPCFHCPQCERGYFSLCKQYQFVGSRSEGGNAEY
HHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEE
VVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCEGKNVIIVGAGTIGLLALQCA
EEEEECCEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
RELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSDIQFDQLVLETAGTP
HHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEECCCCC
QTVSLAIDITGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWE
CEEEEEEEECCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
TAARLLAEKRLQLTPLIAHRGDAESFAEAVKALNGAPMQGKILLQLS
HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHE
CCEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCC
FSGYVESYGTGVTDMQPGDAVACVPLLPCFHCPQCERGYFSLCKQYQFVGSRSEGGNAEY
HHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEE
VVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCEGKNVIIVGAGTIGLLALQCA
EEEEECCEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
RELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSDIQFDQLVLETAGTP
HHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEECCCCC
QTVSLAIDITGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWE
CEEEEEEEECCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
TAARLLAEKRLQLTPLIAHRGDAESFAEAVKALNGAPMQGKILLQLS
HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]