Click here to switch to the map view.

The map label for this gene is epd

Identifier: 29143339

GI number: 29143339

Start: 3080608

End: 3081654

Strand: Reverse

Name: epd

Synonym: t2989

Alternate gene names: 29143339

Gene position: 3081654-3080608 (Counterclockwise)

Preceding gene: 29143345

Following gene: 29143338

Centisome position: 64.31

GC content: 53.87

Gene sequence:

>1047_bases
ATGACCGTACGCATAGCGATTAATGGCTTTGGTCGCATCGGGCGTAACGTGGTTCGTGCTTTGTATGAATCCGGACGTCG
GGCGGAAATTACCGTGGTGGCCATCAACGAGCTGGCGGATGCCGCAGGCATGGCGCATTTGTTGAAATACGATACCAGCC
ACGGGCGTTTTGCATGGGAGGTTCGCCACGAGCGCGAGCAGCTTTTTGTCGGCGACGATGTCATTCGTATTCTGCATGAA
CGAACGCTGGCGGATCTGCCGTGGCGCGAACTGGGCGTGGATGTCGTGTTGGATTGTACGGGCGTATATGGCAACCGGGA
GCATGGCGAGGCGCATATTGCCGCTGGCGCGAAGAAAGTGCTCTTTTCTCATCCGGGCAGCAACGATCTTGACGCCACCG
TCGTTTTTGGCGTGAACCAGAACCAACTGCGTGCGGAACATCGTATTGTCTCAAACGCGTCCTGTACCACGAATTGCATA
ATTCCCGTCATTAAATTGTTGGATGATGCTTACGGCATCGAGTCTGGTACCGTCACGACGATCCACTCCGCGATGAACGA
TCAGCAGGTGATCGACGCGTATCACTCCGATCTACGGCGCACGCGCGCGGCCAGCCAGTCGATTATCCCGGTAGATACAA
AACTGGCGGCAGGCATTACGCGTATATTCCCGCAGTTTAACGACCGTTTTGAGGCGATTGCGGTGCGCGTTCCAACCATT
AATGTGACGGCGATCGATTTAAGCGTAACGGTGAAAAAACCAGTAAAAGCTAGTGAAGTCAACCAGTTGCTGCAAAAAGC
AGCACAAGGTGCATTTCATGGTATAGTTGACTATACGGAATCACCGTTGGTCTCGATAGATTTTAACCACGACCCGCACA
GCGCCATTGTTGATGGCACGCAAACCCGGGTCAGTGGCGCCCACCTGATCAAGACGCTGGTCTGGTGCGATAATGAATGG
GGCTTTGCTAACAGGATGCTCGACACCACGTTAGCGATGGCCGCAGTTGGTTTCAGGCTCGACGCGTCAGCGTCGACAAA
ACTTTAA

Upstream 100 bases:

>100_bases
ACCAATCAGTCGCAGTTTGCGACAGGTGAGGTTTTACTCGACGATAAGCTGCATTACTCTGTCAGCCTCATCTGAATCGG
GATAGCCTTGCAGGAGACCT

Downstream 100 bases:

>100_bases
GCATCATTGAGAGGATTCACCATGTCTGTAATTAAGATGACCGATCTGGATCTGGCCGGGAAACGCGTTTTTATCCGTGC
GGATCTGAACGTACCTGTTA

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTVRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRHEREQLFVGDDVIRILHE
RTLADLPWRELGVDVVLDCTGVYGNREHGEAHIAAGAKKVLFSHPGSNDLDATVVFGVNQNQLRAEHRIVSNASCTTNCI
IPVIKLLDDAYGIESGTVTTIHSAMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTI
NVTAIDLSVTVKKPVKASEVNQLLQKAAQGAFHGIVDYTESPLVSIDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEW
GFANRMLDTTLAMAAVGFRLDASASTKL

Sequences:

>Translated_348_residues
MTVRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRHEREQLFVGDDVIRILHE
RTLADLPWRELGVDVVLDCTGVYGNREHGEAHIAAGAKKVLFSHPGSNDLDATVVFGVNQNQLRAEHRIVSNASCTTNCI
IPVIKLLDDAYGIESGTVTTIHSAMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTI
NVTAIDLSVTVKKPVKASEVNQLLQKAAQGAFHGIVDYTESPLVSIDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEW
GFANRMLDTTLAMAAVGFRLDASASTKL
>Mature_347_residues
TVRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRHEREQLFVGDDVIRILHER
TLADLPWRELGVDVVLDCTGVYGNREHGEAHIAAGAKKVLFSHPGSNDLDATVVFGVNQNQLRAEHRIVSNASCTTNCII
PVIKLLDDAYGIESGTVTTIHSAMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTIN
VTAIDLSVTVKKPVKASEVNQLLQKAAQGAFHGIVDYTESPLVSIDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWG
FANRMLDTTLAMAAVGFRLDASASTKL

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily

Homologues:

Organism=Homo sapiens, GI7669492, Length=336, Percent_Identity=37.5, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI7657116, Length=327, Percent_Identity=37.0030581039755, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI1789295, Length=339, Percent_Identity=94.1002949852507, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1788079, Length=329, Percent_Identity=41.3373860182371, Blast_Score=259, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17534677, Length=333, Percent_Identity=37.5375375375375, Blast_Score=234, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI32566163, Length=333, Percent_Identity=37.8378378378378, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17568413, Length=333, Percent_Identity=37.8378378378378, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17534679, Length=333, Percent_Identity=37.2372372372372, Blast_Score=234, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6322468, Length=328, Percent_Identity=39.3292682926829, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6321631, Length=330, Percent_Identity=40, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322409, Length=328, Percent_Identity=38.719512195122, Blast_Score=251, Evalue=9e-68,
Organism=Drosophila melanogaster, GI17933600, Length=328, Percent_Identity=37.5, Blast_Score=231, Evalue=4e-61,
Organism=Drosophila melanogaster, GI18110149, Length=328, Percent_Identity=37.5, Blast_Score=231, Evalue=4e-61,
Organism=Drosophila melanogaster, GI85725000, Length=328, Percent_Identity=37.1951219512195, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI22023983, Length=328, Percent_Identity=37.1951219512195, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=34.8484848484849, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): E4PD_SALA4 (B5F5J5)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002147984.1
- ProteinModelPortal:   B5F5J5
- SMR:   B5F5J5
- PRIDE:   B5F5J5
- GeneID:   6793310
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B3232
- HOGENOM:   HBG571736
- OMA:   IQAKAVR
- ProtClustDB:   PRK13535
- GO:   GO:0005737
- HAMAP:   MF_01640
- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01532

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.72

Molecular weight: Translated: 38126; Mature: 37995

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 155-155 BINDING 81-81 BINDING 200-200 BINDING 236-236 BINDING 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWE
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEE
VRHEREQLFVGDDVIRILHERTLADLPWRELGVDVVLDCTGVYGNREHGEAHIAAGAKKV
EECCCHHEEECHHHHHHHHHHHHHCCCHHHCCCEEEEEEECCCCCCCCCCEEECCCCCEE
LFSHPGSNDLDATVVFGVNQNQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTT
EEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
IHSAMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTI
EHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEE
NVTAIDLSVTVKKPVKASEVNQLLQKAAQGAFHGIVDYTESPLVSIDFNHDPHSAIVDGT
EEEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCEECCC
QTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMAAVGFRLDASASTKL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEECCCCCCCC
>Mature Secondary Structure 
TVRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWE
EEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEE
VRHEREQLFVGDDVIRILHERTLADLPWRELGVDVVLDCTGVYGNREHGEAHIAAGAKKV
EECCCHHEEECHHHHHHHHHHHHHCCCHHHCCCEEEEEEECCCCCCCCCCEEECCCCCEE
LFSHPGSNDLDATVVFGVNQNQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTT
EEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
IHSAMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTI
EHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECEE
NVTAIDLSVTVKKPVKASEVNQLLQKAAQGAFHGIVDYTESPLVSIDFNHDPHSAIVDGT
EEEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCEECCC
QTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMAAVGFRLDASASTKL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA