Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 29142789

GI number: 29142789

Start: 2472087

End: 2473142

Strand: Direct

Name: cysM [H]

Synonym: t2401

Alternate gene names: 29142789

Gene position: 2472087-2473142 (Clockwise)

Preceding gene: 29142783

Following gene: 29142792

Centisome position: 51.59

GC content: 54.64

Gene sequence:

>1056_bases
ATGATGAGTAGCAATTGGGTTAAAAATGCCATTAATGAAATTAACGCTGACCACCAGCGCTCAGCGGATACGCATCTTAT
TCGTTTGCCCCTGTCGGCATTTCCAGGTATCCAGCTTTACCTGAAAGACGAAAGCACGCATCCCACCGGTAGCCTCAAGC
ATCGTCTGGCGCGCTCGCTGTTCCTTTATGGGTTGTGCAATGGCTGGATTAAAGAAGACACTCCGATTATTGAAGCGTCA
TCAGGCTCAACGGCGATTTCCGAAGCCTGGTTCGCGCGTTTACTGGGACTGCCGTTCATCGCCGCCATGCCCGCCTGTAC
CGCAAAACGTAAAATCGAACAGATTCAATTTTACGGCGGCCACTGTCATTTTGTGGAGAGCGCCTGCGAAATTTATGCCG
CCTCCGAGCGGCTGGCGCATGAACTGAACGGTCACTATATGGACCAGTTTACCTACGCAGAACGAGCTACCGACTGGCGG
GGCAACAATAATATTGCCGACAGTATTTTCCGCCAGATGCGCAACGAACCCCATCCGGTACCGCGATTTATCGTCATGAG
CGCCGGAACGGGCGGAACCTCTGCGACGATTGGGCGCTATATTCGCTGCCAGGGCTATGATACTCAGCTCATGGTGGTGG
ATCCGGAAAATTCTGTCTTTTTACCTTACTGGCAGGATCGCGACGCTTCATTACGCAGCCCGGTAGGCAGTAAAATTGAA
GGAATTGGTCGTCCGCGAGTAGAGCCTTCTTTTATTCCGGATGTCGTGGATGAGATGCTGCGCGTGCCGGACGCCGCCAG
CGTTGCCACCGCACACTGGCTGGAAACGCAGCTAGGCCGTAAAGTCGGCGCCTCTACCGGCACGAATATGTGGGGAGCGC
TGCAGCTAGCGGCCCGGATGCGCGAGGCTGGAGAAACCGGCGCTATCGTGACGTTATTGTGCGATAGCGGCGATCGCTAT
CTGGATACCTATTACCATCCGGCCTGGGTTAGCGACCATATCGGCGATTTGACGCCGTGGTCAGCGGCCATCGCAAAATT
ACTTACCGGCGACTAG

Upstream 100 bases:

>100_bases
GAGAATATTTTTCTCCTTACATTGTAATTTAAAGGTCAAATAGCAACAATTTTTTCCGTACTTTTCGCTACTCTTGGCAC
AAAATGATAAATGGATATTA

Downstream 100 bases:

>100_bases
AAACCAAATAAATATCCTCCGGCATAGCCGGAGGTTTTTCTGATGCGCCTGTAAGGCTCTCTTACCAGCCGCGCCCTAAC
AGGCGCATACGATCTGACAT

Product: lyase

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MMSSNWVKNAINEINADHQRSADTHLIRLPLSAFPGIQLYLKDESTHPTGSLKHRLARSLFLYGLCNGWIKEDTPIIEAS
SGSTAISEAWFARLLGLPFIAAMPACTAKRKIEQIQFYGGHCHFVESACEIYAASERLAHELNGHYMDQFTYAERATDWR
GNNNIADSIFRQMRNEPHPVPRFIVMSAGTGGTSATIGRYIRCQGYDTQLMVVDPENSVFLPYWQDRDASLRSPVGSKIE
GIGRPRVEPSFIPDVVDEMLRVPDAASVATAHWLETQLGRKVGASTGTNMWGALQLAARMREAGETGAIVTLLCDSGDRY
LDTYYHPAWVSDHIGDLTPWSAAIAKLLTGD

Sequences:

>Translated_351_residues
MMSSNWVKNAINEINADHQRSADTHLIRLPLSAFPGIQLYLKDESTHPTGSLKHRLARSLFLYGLCNGWIKEDTPIIEAS
SGSTAISEAWFARLLGLPFIAAMPACTAKRKIEQIQFYGGHCHFVESACEIYAASERLAHELNGHYMDQFTYAERATDWR
GNNNIADSIFRQMRNEPHPVPRFIVMSAGTGGTSATIGRYIRCQGYDTQLMVVDPENSVFLPYWQDRDASLRSPVGSKIE
GIGRPRVEPSFIPDVVDEMLRVPDAASVATAHWLETQLGRKVGASTGTNMWGALQLAARMREAGETGAIVTLLCDSGDRY
LDTYYHPAWVSDHIGDLTPWSAAIAKLLTGD
>Mature_351_residues
MMSSNWVKNAINEINADHQRSADTHLIRLPLSAFPGIQLYLKDESTHPTGSLKHRLARSLFLYGLCNGWIKEDTPIIEAS
SGSTAISEAWFARLLGLPFIAAMPACTAKRKIEQIQFYGGHCHFVESACEIYAASERLAHELNGHYMDQFTYAERATDWR
GNNNIADSIFRQMRNEPHPVPRFIVMSAGTGGTSATIGRYIRCQGYDTQLMVVDPENSVFLPYWQDRDASLRSPVGSKIE
GIGRPRVEPSFIPDVVDEMLRVPDAASVATAHWLETQLGRKVGASTGTNMWGALQLAARMREAGETGAIVTLLCDSGDRY
LDTYYHPAWVSDHIGDLTPWSAAIAKLLTGD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=300, Percent_Identity=24.6666666666667, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI295821200, Length=300, Percent_Identity=24.6666666666667, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4557415, Length=300, Percent_Identity=24.6666666666667, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=27.7955271565495, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=355, Percent_Identity=32.6760563380282, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17539800, Length=356, Percent_Identity=30.3370786516854, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539640, Length=360, Percent_Identity=28.6111111111111, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=28.5245901639344, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=27.6450511945392, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562970, Length=310, Percent_Identity=27.0967741935484, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=29.042904290429, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321449, Length=339, Percent_Identity=25.6637168141593, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643623, Length=321, Percent_Identity=26.4797507788162, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129101, Length=321, Percent_Identity=26.4797507788162, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38903; Mature: 38903

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSNWVKNAINEINADHQRSADTHLIRLPLSAFPGIQLYLKDESTHPTGSLKHRLARSL
CCCCHHHHHHHHHCCCCHHCCCCCEEEEEEHHHCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYGLCNGWIKEDTPIIEASSGSTAISEAWFARLLGLPFIAAMPACTAKRKIEQIQFYGG
HHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHEEECC
HCHFVESACEIYAASERLAHELNGHYMDQFTYAERATDWRGNNNIADSIFRQMRNEPHPV
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
PRFIVMSAGTGGTSATIGRYIRCQGYDTQLMVVDPENSVFLPYWQDRDASLRSPVGSKIE
CEEEEEECCCCCCHHHHCCEEEECCCCCEEEEECCCCCEEEEEECCCCCCHHCCCCCHHH
GIGRPRVEPSFIPDVVDEMLRVPDAASVATAHWLETQLGRKVGASTGTNMWGALQLAARM
CCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
REAGETGAIVTLLCDSGDRYLDTYYHPAWVSDHIGDLTPWSAAIAKLLTGD
HHCCCCCCEEEEEECCCCCEEHHCCCCCHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MMSSNWVKNAINEINADHQRSADTHLIRLPLSAFPGIQLYLKDESTHPTGSLKHRLARSL
CCCCHHHHHHHHHCCCCHHCCCCCEEEEEEHHHCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYGLCNGWIKEDTPIIEASSGSTAISEAWFARLLGLPFIAAMPACTAKRKIEQIQFYGG
HHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHEEECC
HCHFVESACEIYAASERLAHELNGHYMDQFTYAERATDWRGNNNIADSIFRQMRNEPHPV
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
PRFIVMSAGTGGTSATIGRYIRCQGYDTQLMVVDPENSVFLPYWQDRDASLRSPVGSKIE
CEEEEEECCCCCCHHHHCCEEEECCCCCEEEEECCCCCEEEEEECCCCCCHHCCCCCHHH
GIGRPRVEPSFIPDVVDEMLRVPDAASVATAHWLETQLGRKVGASTGTNMWGALQLAARM
CCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
REAGETGAIVTLLCDSGDRYLDTYYHPAWVSDHIGDLTPWSAAIAKLLTGD
HHCCCCCCEEEEEECCCCCEEHHCCCCCHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9034314; 10688204 [H]