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The map label for this gene is ykgC [H]

Identifier: 29142697

GI number: 29142697

Start: 2367820

End: 2369145

Strand: Reverse

Name: ykgC [H]

Synonym: t2298

Alternate gene names: 29142697

Gene position: 2369145-2367820 (Counterclockwise)

Preceding gene: 29142707

Following gene: 29142696

Centisome position: 49.44

GC content: 52.34

Gene sequence:

>1326_bases
ATGACACAGTATCAGGCGCTCATTATTGGTTTTGGCAAGGCAGGAAAAACGTTGGCGGCAACTCTGGCGAAGACGGGATG
GCGCGTGGCGATTATCGAACAGTCCGCCAGTATGTTTGGCGGAACCTGTATCAACATTGGCTGTATTCCAACGAAAACGC
TGGTGTATGACGCGGAACGTGAGGGCGATTTTTCTGTCGCCATGCAACGCAAAGCGGCGGTCGTAAATTTTTTACGCGAC
AAAAATTTTCATAATCTTGCCGACCTGGACAATGTCGATGTGATTGAGGGAAGGGCGGAGTTTATTGATAACCATACCTT
ACGGGTATTTCAGGCGGACGGCGAGCGGGTGTTACGGGGAGAAAAGATCTTCATTAATACTGGCGCAGAGTCGGTGATCC
CGGCTATTACGGGCTTAACAACGACGGCAGGGGTGTTCGATAGCACCGGGCTACTAAGCCTGAGCCAGCGTCCGGCGCGG
CTGGGGATTTTAGGCGGCGGTTATATTGGCCTTGAATTTGCCTCAATGTTCGCTAACTTCGGTACGAAGGTCACTATCTT
TGAAGCAGCGCCGCAATTCTTGCCTCGTGAAGATCGGGATATCGCGCAGGCAATTACCCACATTTTACAGGAAAAGGGCG
TCGAGCTAATTTTAAACGCCAACGTACAGGCCGTATCCTCAACGGAGGGCGCGGTACAAGTTGAAACGCCGGAAGGCGCG
CATCTTGTGGATGCCCTGCTGGTGGCGTCGGGGCGAAAACCGGCGACGGCTGGCTTACAGTTGCAGAACGCCGGTGTGGC
GGTGAACGAACGCGGCGGGATCATCGTGGATGATTACCTGCGTACCACGGCGGACAATATCTGGGCGATGGGCGATGTTA
CCGGTGGGTTGCAGTTTACCTATATTTCACTGGATGATTTTCGTATTGTACGCGACGGGTTATTGGGAGATGGCAAACGC
AGTACCCGCGATCGCCAGAACGTACCGTATTCCGTCTTTATGACGCCGCCGCTCTCTCGTGTCGGGCTGACGGAAGAACA
AGCGCGGGCAAGCGGCGCAACGGTGCAGGTGGTGACATTACCGGTGGCGGCGATCCCTCGCGCCCGTGTTATGAATGATA
CCCGTGGCGTACTAAAAGCGGTAGTGGACGTGAATACGCAGCGTATTGTAGGGGTGTCATTGTTATGCGTCGATTCTCAT
GAAATGATTAATATCGTTAAAACCGTTATGGATGCAGATTTACCTTATACGGTGTTACGCGACCAGATATTTACCCATCC
TACAATGAGTGAGTCTTTAAACGATCTCTTCTCTCTCATTAAGTAA

Upstream 100 bases:

>100_bases
ACGATAAGACAAAAAATGACGCGTTACGGATAACCCTGTCTTTTTTGACGTTATTTATACTTGTCCTGACAAACAGATGG
TGATTTGGCGGAGAAAGAAG

Downstream 100 bases:

>100_bases
AACATAAATAATGTAGCCCTGTTAATCAGGGCTTTTTTTTGCCTGTCAGACCATAAAAATACGACAGGACAAATATGCTG
GCGTCTGAAAGAAAAGGCTT

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVYDAEREGDFSVAMQRKAAVVNFLRD
KNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRGEKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPAR
LGILGGGYIGLEFASMFANFGTKVTIFEAAPQFLPREDRDIAQAITHILQEKGVELILNANVQAVSSTEGAVQVETPEGA
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFTYISLDDFRIVRDGLLGDGKR
STRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTLPVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSH
EMINIVKTVMDADLPYTVLRDQIFTHPTMSESLNDLFSLIK

Sequences:

>Translated_441_residues
MTQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVYDAEREGDFSVAMQRKAAVVNFLRD
KNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRGEKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPAR
LGILGGGYIGLEFASMFANFGTKVTIFEAAPQFLPREDRDIAQAITHILQEKGVELILNANVQAVSSTEGAVQVETPEGA
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFTYISLDDFRIVRDGLLGDGKR
STRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTLPVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSH
EMINIVKTVMDADLPYTVLRDQIFTHPTMSESLNDLFSLIK
>Mature_440_residues
TQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVYDAEREGDFSVAMQRKAAVVNFLRDK
NFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRGEKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPARL
GILGGGYIGLEFASMFANFGTKVTIFEAAPQFLPREDRDIAQAITHILQEKGVELILNANVQAVSSTEGAVQVETPEGAH
LVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFTYISLDDFRIVRDGLLGDGKRS
TRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTLPVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSHE
MINIVKTVMDADLPYTVLRDQIFTHPTMSESLNDLFSLIK

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=29.5010845986985, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=27.7056277056277, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI291045266, Length=438, Percent_Identity=24.4292237442922, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI33519430, Length=436, Percent_Identity=25.2293577981651, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI33519428, Length=436, Percent_Identity=25.2293577981651, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI33519426, Length=436, Percent_Identity=25.2293577981651, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI148277065, Length=436, Percent_Identity=25.2293577981651, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI148277071, Length=436, Percent_Identity=25.2293577981651, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=25.9259259259259, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI291045268, Length=289, Percent_Identity=25.9515570934256, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87081717, Length=441, Percent_Identity=74.3764172335601, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=28.4140969162996, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=29.5612009237875, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=27.0386266094421, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789065, Length=181, Percent_Identity=32.0441988950276, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=28.695652173913, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71983419, Length=344, Percent_Identity=29.6511627906977, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=344, Percent_Identity=29.6511627906977, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=25.2631578947368, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=441, Percent_Identity=22.4489795918367, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=133, Percent_Identity=38.3458646616541, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=29.3991416309013, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=24.622030237581, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=489, Percent_Identity=26.9938650306748, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=29.1576673866091, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=27.5210084033613, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=27.5210084033613, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=27.5210084033613, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=25.8947368421053, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 47598; Mature: 47467

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVYDAER
CCCEEEEEEEECCCCHHHHHHHHHCCCEEEEEECCHHHCCCEEEEECCCCCCEEEEECCC
EGDFSVAMQRKAAVVNFLRDKNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCEEEEEECCCCEEECC
EKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPARLGILGGGYIGLEFASMFANF
CEEEEECCCHHHHHHHHCCCHHCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHC
GTKVTIFEAAPQFLPREDRDIAQAITHILQEKGVELILNANVQAVSSTEGAVQVETPEGA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCEEEEECCCCH
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFT
HHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCEEEEHHHHHHHCCEEEEECCCCCEEEE
YISLDDFRIVRDGLLGDGKRSTRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTL
EEECCCHHHHHHCCCCCCCCCCCHHCCCCEEEEECCCHHHCCCCHHHHHCCCCEEEEEEE
PVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSHEMINIVKTVMDADLPYTVLR
CHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCHHHHH
DQIFTHPTMSESLNDLFSLIK
HHHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
TQYQALIIGFGKAGKTLAATLAKTGWRVAIIEQSASMFGGTCINIGCIPTKTLVYDAER
CCEEEEEEEECCCCHHHHHHHHHCCCEEEEEECCHHHCCCEEEEECCCCCCEEEEECCC
EGDFSVAMQRKAAVVNFLRDKNFHNLADLDNVDVIEGRAEFIDNHTLRVFQADGERVLRG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCEEEEEECCCCEEECC
EKIFINTGAESVIPAITGLTTTAGVFDSTGLLSLSQRPARLGILGGGYIGLEFASMFANF
CEEEEECCCHHHHHHHHCCCHHCCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHC
GTKVTIFEAAPQFLPREDRDIAQAITHILQEKGVELILNANVQAVSSTEGAVQVETPEGA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCEEEEECCCCH
HLVDALLVASGRKPATAGLQLQNAGVAVNERGGIIVDDYLRTTADNIWAMGDVTGGLQFT
HHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCEEEEHHHHHHHCCEEEEECCCCCEEEE
YISLDDFRIVRDGLLGDGKRSTRDRQNVPYSVFMTPPLSRVGLTEEQARASGATVQVVTL
EEECCCHHHHHHCCCCCCCCCCCHHCCCCEEEEECCCHHHCCCCHHHHHCCCCEEEEEEE
PVAAIPRARVMNDTRGVLKAVVDVNTQRIVGVSLLCVDSHEMINIVKTVMDADLPYTVLR
CHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCHHHHH
DQIFTHPTMSESLNDLFSLIK
HHHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]