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The map label for this gene is bioF [H]

Identifier: 29142507

GI number: 29142507

Start: 2154117

End: 2155274

Strand: Reverse

Name: bioF [H]

Synonym: t2092

Alternate gene names: 29142507

Gene position: 2155274-2154117 (Counterclockwise)

Preceding gene: 29142508

Following gene: 29142506

Centisome position: 44.98

GC content: 60.36

Gene sequence:

>1158_bases
ATGAGTTGGCAACAACGCGTCGACGATGCGCTGACGGCGCGTCGGGCGACGGATACGTTGCGCCGCCGCTATGTGGTATC
GCAGGGCGCCGGACGCTGGCTGGTAGCGAACGGGCGACAGTATCTTAACTTTTCCAGCAATGATTACCTCGGCTTAAGTC
AACATCCGCAGATTATTCGCGCCTGGCAACAGGCAGCGACGCGTTTTGGCGTCGGCAGCGGCGGGTCGGGTCATATCAGC
GGTTATTCCGTGGCGCACCAGGCGTTAGAGGAGGAACTGGCGCAATGGTTAGGATATCCACGCGCGCTGCTGTTTATCTC
TGGCTTTGCGGCGAATCAGGCGGTCATTACCGCCTTAATGAAAAAAAATGACCGGATTGTGGCCGACAGGTTGAGTCATG
CTTCCCTGCTGGAAGCCGCTAATCTGAGTCCGGCGCAGCTTCGCCGCTTTATCCATAACGATACGCAGCATCTGTCGCGT
TTACTGCAATCGCCCTGCGTGGGTCAGCAACTGGTGGTGACAGAAGGTGTATACAGCATGGACGGCGACAGCGCGCCGCT
GGCGGAAATCCAGCACATTGCCCGCAGGCATCATGCCTGGCTGTTGGTTGATGATGCGCACGGCATCGGCGTGACTGGCG
ATGAGGGGCGGGGCACCTGCTGGCAGCGGGGGGTGAAGCCTGAGTTGCTGGTGGTGACTTTCGGTAAGGGGTTTGGCGTC
AGCGGCGCAGCGGTGCTCTGCTCGGAAAGCGTCGCAGATTATCTGCTGCAATTCGCCCGTCATCTGGTTTACAGCACCAG
TATGCCGCCCGCCCAGGCGCAGGCGTTAAGCGCCTCGCTGGCGGTGATCCGTAGCGATGAAGGTCGTGAACGGCGCGAAA
AACTCGCCGCTCTGGTTCAGCGCTTTCGGGCCGGCGTTAACGCGTCCCGATTTACGCTACTGAATGCCCATAGCGCCATC
CAGCCGTTAATCGTGGGCGATAACAGCCGTGCATTGCGCCTGGCGGAGGCGCTGCGTCAACAAGGATGCTGGGCGACGGC
GATTCGTCCGCCGACGGTGCCTGTCGGTACGGCGCGCCTGCGCTTAACGTTAACGCAGGCGCATGAAGCGTGCGATATAG
ACCGTCTGCTGGAGGTGCTGCATGGCGCAGGTGAATAA

Upstream 100 bases:

>100_bases
AGCAGACCAGGGTGCTGGCGGGCGATAACGAGCAGCAGCAACGTCTGGAGCAGACGCTGATGACGCCTGACACCGATGAT
TATTACAACGCGGCAGCCTT

Downstream 100 bases:

>100_bases
GCAGGCTATTGCGGCGGCGTTTGGCCGGGCCGCATCGCAATACGAACAGCACGCCTCTTTACAGCAACACAGCGCGGATG
CGCTGCTGACGCTGTTGACA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAATRFGVGSGGSGHIS
GYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSR
LLQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGRERREKLAALVQRFRAGVNASRFTLLNAHSAI
QPLIVGDNSRALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE

Sequences:

>Translated_385_residues
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAATRFGVGSGGSGHIS
GYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSR
LLQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGRERREKLAALVQRFRAGVNASRFTLLNAHSAI
QPLIVGDNSRALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE
>Mature_384_residues
SWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAATRFGVGSGGSGHISG
YSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRL
LQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGVS
GAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGRERREKLAALVQRFRAGVNASRFTLLNAHSAIQ
PLIVGDNSRALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=389, Percent_Identity=33.4190231362468, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI284448556, Length=352, Percent_Identity=35.2272727272727, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI83977444, Length=395, Percent_Identity=30.379746835443, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI83977442, Length=395, Percent_Identity=30.379746835443, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI83977440, Length=395, Percent_Identity=30.379746835443, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=30.327868852459, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4502025, Length=389, Percent_Identity=31.3624678663239, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI40316939, Length=389, Percent_Identity=31.3624678663239, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=29.7814207650273, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI5454084, Length=278, Percent_Identity=25.5395683453237, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786993, Length=384, Percent_Identity=80.2083333333333, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1790046, Length=386, Percent_Identity=34.1968911917098, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71994529, Length=389, Percent_Identity=30.8483290488432, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=384, Percent_Identity=28.6458333333333, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=28.7671232876712, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=28.7671232876712, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71982617, Length=295, Percent_Identity=26.7796610169492, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=295, Percent_Identity=26.7796610169492, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320267, Length=408, Percent_Identity=26.9607843137255, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320438, Length=401, Percent_Identity=27.6807980049875, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323954, Length=219, Percent_Identity=30.1369863013699, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24662918, Length=372, Percent_Identity=30.3763440860215, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17137420, Length=382, Percent_Identity=30.6282722513089, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17136286, Length=382, Percent_Identity=27.2251308900524, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653280, Length=270, Percent_Identity=24.4444444444444, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24653276, Length=270, Percent_Identity=24.4444444444444, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24653278, Length=270, Percent_Identity=24.4444444444444, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42042; Mature: 41911

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCHHHHH
AWQQAATRFGVGSGGSGHISGYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALM
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHH
KKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCVGQQLVVTEGVYSM
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCC
DGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
CCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCC
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGRERREKLAALVQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHH
RFRAGVNASRFTLLNAHSAIQPLIVGDNSRALRLAEALRQQGCWATAIRPPTVPVGTARL
HHHCCCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCEEE
RLTLTQAHEACDIDRLLEVLHGAGE
EEEEHHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCHHHHH
AWQQAATRFGVGSGGSGHISGYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALM
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHH
KKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCVGQQLVVTEGVYSM
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCC
DGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGV
CCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCC
SGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGRERREKLAALVQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHH
RFRAGVNASRFTLLNAHSAIQPLIVGDNSRALRLAEALRQQGCWATAIRPPTVPVGTARL
HHHCCCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCEEE
RLTLTQAHEACDIDRLLEVLHGAGE
EEEEHHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA