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The map label for this gene is ybhO

Identifier: 29142494

GI number: 29142494

Start: 2138925

End: 2140166

Strand: Direct

Name: ybhO

Synonym: t2076

Alternate gene names: 29142494

Gene position: 2138925-2140166 (Clockwise)

Preceding gene: 29142493

Following gene: 29142495

Centisome position: 44.64

GC content: 54.19

Gene sequence:

>1242_bases
ATGAAATGCGGCTGGCGTGAAGGTAATCAAATTCAGCTACTGGAAAACGGCGACCAGTTCTATCCTGCCGTGTTTGAGGC
TATCGCTCAGGCACAGCAAAAAATCATTCTGGAAACCTTTATCTTGTTTGAAGATGAGGTGGGTAAAAAACTCCATGCCG
CTCTGCTAAAAGCTGCACAGCGCGGCGTAAAAGCCGAAGTATTACTCGACGGCTACGGCTCTCCCGATCTCAGCGACGCG
TTTGTCGGCGAATTAACCTCGGCGGGCGTGATTTTTCGCTATTACGACCCCCGCCCGCGTCTACTGGGGTTGCGAACCAA
TATCTTCCGCCGAATGCACCGCAAAATTGTGGTGATTGATGATCGTATTGCCTTTGTCGGCGGCATTAACTACTCCGCCG
AACATATGTCGGATTACGGCCCGCAGGCGAAACAAGACTACGCGGTACGGGTCGAAGGGCCTGTTGTGGCCGATATCCTG
CAATTCGAAGTCGAGAATCTGCCGGGGCAAAGCCCCGCGCGCCGCTGGTGGAAGCGCCATCATCAGGCTGAAGAAAATCG
CCACCCCGGCGAAGCGCAGGCGCTGTTTGTCTGGCGGGATAATGAAGAACACCGCGACGATATCGAACGTCATTATCTGA
AAATGCTGACCCAGGCAAAGCGTGAAGTGATTATCGCTAACGCCTATTTTTTCCCCGGCTATCGCTTGCTCCACGCAATG
CGTAAAGCCGCCCGCCGTGGCGTGAGCGTAAAACTGATTGTCCAGGGAGAACCAGACATGCCGATAGTCAAAGTCGGCGC
GCGGTTGCTCTATAACTATCTGGTGAAGGGCGGCGTGCAGGTTTATGAATACCGACGCCGTCCGCTGCATGGCAAAGTGG
CGCTGATGGACGATCACTGGGCCACGGTAGGGTCGAGTAATCTCGATCCGCTCAGCCTGTCGCTTAACCTTGAAGCTAAC
CTGATCATTCACGATCGTACTTTTAACCAGACCCTACGCGATAACTTACAAGGCATCATCGTGAATGATTGTAAGCAGGT
CGATGAGTCTATGCTGCCGAAACGTACCTGGTGGAACCTGACCAAAAGCGTGCTGGCGTTCCACTTTTTACGCCATTTCC
CGGCGCTGGTCGGCTGGCTACCTGCGCATACCCCGCATCTGGCGCAGGTTCCCCCGCCTGCTCAGCCGGAAATGGAAACC
CAGGATCGCGTTGATCCAGAAAATTCAGGAGTGAAGCCCTAA

Upstream 100 bases:

>100_bases
TTTACGTCAAGAATGCGAACGCCAGTTCTCCTGGGGCGCTACCGTTGCGGAACTGGCGACATTTATCAGACCATGCCCCC
CTTAGCGCGGAGATCCATCT

Downstream 100 bases:

>100_bases
TGGCTAAATCGCATCCGCGCTGGCGGCTGGCTAAAAAAGTGCTGACCTGGCTGTTTTTTATTGCGGTCGTCGTTCTGCTG
GTGGTTTATGCTAAAAAGGT

Product: cardiolipin synthase 2

Products: NA

Alternate protein names: CL synthase

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKCGWREGNQIQLLENGDQFYPAVFEAIAQAQQKIILETFILFEDEVGKKLHAALLKAAQRGVKAEVLLDGYGSPDLSDA
FVGELTSAGVIFRYYDPRPRLLGLRTNIFRRMHRKIVVIDDRIAFVGGINYSAEHMSDYGPQAKQDYAVRVEGPVVADIL
QFEVENLPGQSPARRWWKRHHQAEENRHPGEAQALFVWRDNEEHRDDIERHYLKMLTQAKREVIIANAYFFPGYRLLHAM
RKAARRGVSVKLIVQGEPDMPIVKVGARLLYNYLVKGGVQVYEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
LIIHDRTFNQTLRDNLQGIIVNDCKQVDESMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPHLAQVPPPAQPEMET
QDRVDPENSGVKP

Sequences:

>Translated_413_residues
MKCGWREGNQIQLLENGDQFYPAVFEAIAQAQQKIILETFILFEDEVGKKLHAALLKAAQRGVKAEVLLDGYGSPDLSDA
FVGELTSAGVIFRYYDPRPRLLGLRTNIFRRMHRKIVVIDDRIAFVGGINYSAEHMSDYGPQAKQDYAVRVEGPVVADIL
QFEVENLPGQSPARRWWKRHHQAEENRHPGEAQALFVWRDNEEHRDDIERHYLKMLTQAKREVIIANAYFFPGYRLLHAM
RKAARRGVSVKLIVQGEPDMPIVKVGARLLYNYLVKGGVQVYEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
LIIHDRTFNQTLRDNLQGIIVNDCKQVDESMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPHLAQVPPPAQPEMET
QDRVDPENSGVKP
>Mature_413_residues
MKCGWREGNQIQLLENGDQFYPAVFEAIAQAQQKIILETFILFEDEVGKKLHAALLKAAQRGVKAEVLLDGYGSPDLSDA
FVGELTSAGVIFRYYDPRPRLLGLRTNIFRRMHRKIVVIDDRIAFVGGINYSAEHMSDYGPQAKQDYAVRVEGPVVADIL
QFEVENLPGQSPARRWWKRHHQAEENRHPGEAQALFVWRDNEEHRDDIERHYLKMLTQAKREVIIANAYFFPGYRLLHAM
RKAARRGVSVKLIVQGEPDMPIVKVGARLLYNYLVKGGVQVYEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
LIIHDRTFNQTLRDNLQGIIVNDCKQVDESMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPHLAQVPPPAQPEMET
QDRVDPENSGVKP

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains

Homologues:

Organism=Escherichia coli, GI1787007, Length=413, Percent_Identity=86.4406779661017, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1787502, Length=391, Percent_Identity=26.5984654731458, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YBHO_SALTI (Q8Z883)

Other databases:

- EMBL:   AL627268
- EMBL:   AE014613
- RefSeq:   NP_455350.1
- RefSeq:   NP_805836.1
- ProteinModelPortal:   Q8Z883
- GeneID:   1069191
- GeneID:   1247291
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t2076
- KEGG:   sty:STY0847
- HOGENOM:   HBG694312
- OMA:   EYCQRPL
- ProtClustDB:   PRK11263
- BioCyc:   SENT209261:T2076-MONOMER
- BioCyc:   SENT220341:STY0847-MONOMER
- InterPro:   IPR001736
- SMART:   SM00155

Pfam domain/function: PF00614 PLDc

EC number: 2.7.8.-

Molecular weight: Translated: 47259; Mature: 47259

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS50035 PLD

Important sites: ACT_SITE 113-113 ACT_SITE 290-290

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCGWREGNQIQLLENGDQFYPAVFEAIAQAQQKIILETFILFEDEVGKKLHAALLKAAQ
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDAFVGELTSAGVIFRYYDPRPRLLGLRTNIFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHCCEEEEEE
DRIAFVGGINYSAEHMSDYGPQAKQDYAVRVEGPVVADILQFEVENLPGQSPARRWWKRH
CCEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHH
HQAEENRHPGEAQALFVWRDNEEHRDDIERHYLKMLTQAKREVIIANAYFFPGYRLLHAM
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHH
RKAARRGVSVKLIVQGEPDMPIVKVGARLLYNYLVKGGVQVYEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANLIIHDRTFNQTLRDNLQGIIVNDCKQVDESMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCHHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPHLAQVPPPAQPEMETQDRVDPENSGVKP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MKCGWREGNQIQLLENGDQFYPAVFEAIAQAQQKIILETFILFEDEVGKKLHAALLKAAQ
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDAFVGELTSAGVIFRYYDPRPRLLGLRTNIFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHCCEEEEEE
DRIAFVGGINYSAEHMSDYGPQAKQDYAVRVEGPVVADILQFEVENLPGQSPARRWWKRH
CCEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHH
HQAEENRHPGEAQALFVWRDNEEHRDDIERHYLKMLTQAKREVIIANAYFFPGYRLLHAM
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHH
RKAARRGVSVKLIVQGEPDMPIVKVGARLLYNYLVKGGVQVYEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANLIIHDRTFNQTLRDNLQGIIVNDCKQVDESMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCHHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPHLAQVPPPAQPEMETQDRVDPENSGVKP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504