| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is helD [H]
Identifier: 29142272
GI number: 29142272
Start: 1903289
End: 1905343
Strand: Reverse
Name: helD [H]
Synonym: t1845
Alternate gene names: 29142272
Gene position: 1905343-1903289 (Counterclockwise)
Preceding gene: 29142275
Following gene: 29142269
Centisome position: 39.76
GC content: 54.94
Gene sequence:
>2055_bases ATGGAACTGAAAGCAACTTCTCTTGGAAAACGTCTGGCGCAACACCCGTATGATCGTGCCGTGATCCTCAATGCTGGGGT GAAAGTGTCTGGCGACAGGCATGAATATCTTATTCCATTCAATCAGTTATTGGCGATTCACTGTAAGCGTGGGCTGGTAT GGGGCGAGCTGGAGTTTGTCCTCCCGGAGGATAAAGTCGTGCGTTTGCACGGTACCGAGTGGTCGGAAACCCAGCAATTC CATCGCTATCTGGACGCGCACTGGCGTCGCTGGAGCCAGGAGATGAGTGATGTCGCCGCGCAGGCATTACAGGAGCAATG GGCGCGTATTAGTGAGCGAACGGGCGGAAACCAATGGCTTACCCGTGAACACGTTCGTGGGCTGGAACACGAAATTCGCC AGACGTTTGCCGCCTTACCGCTGCCGGTCTCACGTCTGGAGGAGTTTGCTCACTGTCGCGAGATATGGCGTAAGTGTCTG GCATGGTTACAGGATAGCGAGGGAAGTCGGCAGCAGCATAATCAGGCGTATGCTGATGCCATGCTGGAAGCGCATGCCGA CTTTTTTACGCAGATAGAATCTTCTCCGCTTAATCCTTCCCAGGCCAGGGCGGTGGTTAACGGCGAATCATCGTTACTGG TACTGGCGGGCGCGGGAAGCGGTAAGACCTCGGTGCTGGTGGCGCGCGCGGGTTGGCTGTTGGCGCGCGGGCAAGCCGAT GCGGGGCAAATTCTTTTACTGGCGTTTGGTCGCAAGGCGGCAGAAGAGATGGATGAGCGTATCCGCGAGCGCTTACATAC GGAAGAGATTACTGCCCGTACGTTCCATTCGCTGGCGCTGTATATTATTCAGCAAGGCAGTAAAAAAGCGCCGGTTGTCA GTAAGCTGGAAAGTGACGCCACCGCGCGGCATCAGCTATTTCTGCACACCTGGCGTCAGCAGTGTAGCGAGAAAAAAGCG CAGGCCAAAGGCTGGCGTCAGTGGCTGGAAGAGGAGATGCAGTGGGTAGTGCCGGAAGGTAATTTCTGGGACGATGAGAC ATTGCAGCGGCGTCTGGCCCCTCGCCTGGATCGTTGGGTCAGTTTGATGCGTATGCACGGCGGCGCGCAGGCAGAAATGA TCGCTGGCGCGCCAGAGGAGTGCCGCGAGCTGTTTGGCAAACGCATTAAGTTGATGGCGCCGCTGCTGAAGGCCTGGAAA AGCGCATTGAAAGCGGAAAATGCCGTTGATTTCTCCGGGCTGATCCATCAGGCAATGGTGATCCTCGAAAAAGGGCGTTT TATTAGCCCGTGGAAGCATATTCTGGTCGATGAATTTCAGGATATTTCCCCGCAACGGGCGGCGCTGTTAGAGGCGCTAC GCAAGCAGAATAGCCAGACTACGCTGTTTGCCGTTGGCGATGACTGGCAGGCGATTTACCGTTTTAGCGGGGCGCAGCTC TCCTTAACGACGGCGTTTCATCAGACGTTCGGCGAGGGCGAGCATTGTCACCTGGACACCACGTACCGTTTTAACAGTCG GATTGGCGATATTGCCAATCGCTTTGTACAGCAGAATCCGCACCAACTTAAAAAACCGTTAAATAGTCTGACCCCAGGCG ATAAAAAAGCGGTTACGTTATTGGATGAAAGCCAGTTGGACGCGTTACTGGATAAATTATCCGGCTATGCGAAGGAGGAT GAACGTATCCTGGTGCTGGCGCGCTATCACCATCTGAAACCCGCGAGTCTACAAAAAGCGGCGACTCGCTGGCCGAAGTT ACAGATAGATTTCATGACTATCCATGCCAGCAAAGGCCAACAGGCCGATTACGTGATTCTTGTCGGATTGCAGGAGGGTA ACGACGGTTTCCCCGCCCCGGCGCGAGAATCCATTATGGAAAGTGCGCTTTTTCCTCAGGTTGAGGATTTTCCGGACGCT GAAGAGCGGCGTTTGTTATATGTGGCGTTGACGCGCGCGCGTGCGCGGGTCTGGCTGCTTTTCAATAAAGATAATCCCTC GCGCTTTGTGGAGGCGCTTAAACAGCTGGATGTGCCGGTGGCGAGGAAGCCCTAA
Upstream 100 bases:
>100_bases TCTATTACTGCGGGCAATTGTAACGTTTTTTTAGACTGGAGCACGTTTTCTCTGGCGGTTACACTGATAAGCACATCTTT ACGTCTGGATTCGCTGAGTC
Downstream 100 bases:
>100_bases AGCGCGGGCGGTATAGCATCCCGCCCGCGTAGCGGTTATTTCAGGCGCTCGGCCAGATAACGCGCATAATCCGGAATAAG AATATCTACAGCGTCATTAA
Product: DNA helicase IV
Products: NA
Alternate protein names: 75 kDa helicase [H]
Number of amino acids: Translated: 684; Mature: 684
Protein sequence:
>684_residues MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPEDKVVRLHGTEWSETQQF HRYLDAHWRRWSQEMSDVAAQALQEQWARISERTGGNQWLTREHVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCL AWLQDSEGSRQQHNQAYADAMLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDATARHQLFLHTWRQQCSEKKA QAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWVSLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWK SALKAENAVDFSGLIHQAMVILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL SLTTAFHQTFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTLLDESQLDALLDKLSGYAKED ERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQQADYVILVGLQEGNDGFPAPARESIMESALFPQVEDFPDA EERRLLYVALTRARARVWLLFNKDNPSRFVEALKQLDVPVARKP
Sequences:
>Translated_684_residues MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPEDKVVRLHGTEWSETQQF HRYLDAHWRRWSQEMSDVAAQALQEQWARISERTGGNQWLTREHVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCL AWLQDSEGSRQQHNQAYADAMLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDATARHQLFLHTWRQQCSEKKA QAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWVSLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWK SALKAENAVDFSGLIHQAMVILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL SLTTAFHQTFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTLLDESQLDALLDKLSGYAKED ERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQQADYVILVGLQEGNDGFPAPARESIMESALFPQVEDFPDA EERRLLYVALTRARARVWLLFNKDNPSRFVEALKQLDVPVARKP >Mature_684_residues MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPEDKVVRLHGTEWSETQQF HRYLDAHWRRWSQEMSDVAAQALQEQWARISERTGGNQWLTREHVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCL AWLQDSEGSRQQHNQAYADAMLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDATARHQLFLHTWRQQCSEKKA QAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWVSLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWK SALKAENAVDFSGLIHQAMVILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL SLTTAFHQTFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTLLDESQLDALLDKLSGYAKED ERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQQADYVILVGLQEGNDGFPAPARESIMESALFPQVEDFPDA EERRLLYVALTRARARVWLLFNKDNPSRFVEALKQLDVPVARKP
Specific function: Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP [H]
COG id: COG0210
COG function: function code L; Superfamily I DNA and RNA helicases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]
Homologues:
Organism=Escherichia coli, GI1787196, Length=684, Percent_Identity=83.9181286549708, Blast_Score=1197, Evalue=0.0, Organism=Escherichia coli, GI48994965, Length=341, Percent_Identity=29.9120234604106, Blast_Score=101, Evalue=2e-22, Organism=Escherichia coli, GI2367296, Length=339, Percent_Identity=27.7286135693215, Blast_Score=92, Evalue=1e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000212 - InterPro: IPR014016 - InterPro: IPR022161 - InterPro: IPR003661 [H]
Pfam domain/function: PF12462 Nucleolin_N; PF00580 UvrD-helicase [H]
EC number: =3.6.4.12 [H]
Molecular weight: Translated: 78039; Mature: 78039
Theoretical pI: Translated: 8.20; Mature: 8.20
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFV CCCCHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEECCHHHHHHHHHHCCCEEEEEEEE LPEDKVVRLHGTEWSETQQFHRYLDAHWRRWSQEMSDVAAQALQEQWARISERTGGNQWL CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH TREHVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCLAWLQDSEGSRQQHNQAYADA HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH MLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD HHHHHHHHHHHHCCCCCCHHHCEEEEECCCCEEEEEECCCCCCEEEEEECCEEEECCCCC AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDA CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCH TARHQLFLHTWRQQCSEKKAQAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHH SLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWKSALKAENAVDFSGLIHQAMV HHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH ILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCEE SLTTAFHQTFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTL EHHHHHHHHCCCCCEEEEECEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEE LDESQLDALLDKLSGYAKEDERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQ ECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEECCCCC QADYVILVGLQEGNDGFPAPARESIMESALFPQVEDFPDAEERRLLYVALTRARARVWLL CCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHCEEEEEEEECCCEEEEEE FNKDNPSRFVEALKQLDVPVARKP EECCCHHHHHHHHHHCCCCCCCCC >Mature Secondary Structure MELKATSLGKRLAQHPYDRAVILNAGVKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFV CCCCHHHHHHHHHHCCCCCEEEEECCEEECCCCCEEECCHHHHHHHHHHCCCEEEEEEEE LPEDKVVRLHGTEWSETQQFHRYLDAHWRRWSQEMSDVAAQALQEQWARISERTGGNQWL CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH TREHVRGLEHEIRQTFAALPLPVSRLEEFAHCREIWRKCLAWLQDSEGSRQQHNQAYADA HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH MLEAHADFFTQIESSPLNPSQARAVVNGESSLLVLAGAGSGKTSVLVARAGWLLARGQAD HHHHHHHHHHHHCCCCCCHHHCEEEEECCCCEEEEEECCCCCCEEEEEECCEEEECCCCC AGQILLLAFGRKAAEEMDERIRERLHTEEITARTFHSLALYIIQQGSKKAPVVSKLESDA CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCH TARHQLFLHTWRQQCSEKKAQAKGWRQWLEEEMQWVVPEGNFWDDETLQRRLAPRLDRWV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHH SLMRMHGGAQAEMIAGAPEECRELFGKRIKLMAPLLKAWKSALKAENAVDFSGLIHQAMV HHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH ILEKGRFISPWKHILVDEFQDISPQRAALLEALRKQNSQTTLFAVGDDWQAIYRFSGAQL HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCEE SLTTAFHQTFGEGEHCHLDTTYRFNSRIGDIANRFVQQNPHQLKKPLNSLTPGDKKAVTL EHHHHHHHHCCCCCEEEEECEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEE LDESQLDALLDKLSGYAKEDERILVLARYHHLKPASLQKAATRWPKLQIDFMTIHASKGQ ECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEEECCCCC QADYVILVGLQEGNDGFPAPARESIMESALFPQVEDFPDAEERRLLYVALTRARARVWLL CCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHCEEEEEEEECCCEEEEEE FNKDNPSRFVEALKQLDVPVARKP EECCCHHHHHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2542273; 8905232; 9278503 [H]