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The map label for this gene is btuD

Identifier: 29141687

GI number: 29141687

Start: 1289637

End: 1290386

Strand: Direct

Name: btuD

Synonym: t1223

Alternate gene names: 29141687

Gene position: 1289637-1290386 (Clockwise)

Preceding gene: 29141686

Following gene: 29141688

Centisome position: 26.91

GC content: 56.93

Gene sequence:

>750_bases
ATGTCTCAATTGATGCAATTAAAGGACGTCGCCGAGAGCACCCGCCTGGGGCCGCTTTCCGGCGAAGTAAGCGCAGGAGA
GATCCTTCATCTTGTCGGGCCGAACGGCGCCGGGAAAAGCACGCTACTGGCGCGTATGGCGGGGTTAACCTCCGGCGAGG
GGAGCATCAGGTTTGGCGGAGCGCCGCTGGAGGCATGGGCGACGGCAACGCTTGCCCAACACCGCGCTTATCTTGCGCAA
CAGCAAAATCCGCCGTTCGCCATGCCGGTCTGGCATTACCTGACATTGCATCAACCTGATAAAACGCGAACCGGGCAGCT
TAACGAGGTGGCCGATATGCTTGGATTGGGCGACAAACTGGGGCGAAGCGTGAATCAGCTTTCCGGTGGCGAGTGGCAGC
GCGTTCGCCTTGCTGCCGTTGTACTACAAATTCATCCCGACGCTAATCCGGTCGGTCAATTATTGCTGCTTGATGAGCCG
ATGAACAGTCTCGATGTTGCGCAACAAAACGCTCTGGATCGGGTATTACATCATTTATGTCAGGCAGGAATTGCGATTGT
GATGAGTAGCCACGATCTGAACCACACGCTGCGCCATGCGCATAAAGCCTGGTTACTAAAGCGCGGTAAACTCATTGCCT
GCGGCCGCCGGGAAGAGGTGCTCACCCCCTCTTATCTGGCGCAAGCCTACGGTTTGCGCTTTCGACGACTCGACGTCGAG
GGGCATCCAATGCTCATTTCGGCCACTTAA

Upstream 100 bases:

>100_bases
TGGTAGGCCGGGATGGTCAGGTGGTACAGCGTTTTTCGCCGGATATGACGCCTGAAGATCCTATTGTGATGGAAAGCATA
AAAATCGCGTTGGCAAAATA

Downstream 100 bases:

>100_bases
GTAAAATCGTTTCTTGAAAAGCAGGTAATTTCGACGCTAAATTAATACCAAAATAAAAACAGAGGATTGTTGCGGCATGC
GTTTTTGGCTTCTTGTTATC

Product: vitamin B12-transporter ATPase

Products: NA

Alternate protein names: Vitamin B12-transporting ATPase

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSQLMQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLEAWATATLAQHRAYLAQ
QQNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEP
MNSLDVAQQNALDRVLHHLCQAGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVE
GHPMLISAT

Sequences:

>Translated_249_residues
MSQLMQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLEAWATATLAQHRAYLAQ
QQNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEP
MNSLDVAQQNALDRVLHHLCQAGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVE
GHPMLISAT
>Mature_248_residues
SQLMQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGGAPLEAWATATLAQHRAYLAQQ
QNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKLGRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPM
NSLDVAQQNALDRVLHHLCQAGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVEG
HPMLISAT

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system

COG id: COG4138

COG function: function code H; ABC-type cobalamin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI46592915, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592898, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592964, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592956, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI46592971, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI46592978, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788002, Length=247, Percent_Identity=80.9716599190283, Blast_Score=406, Evalue=1e-115,
Organism=Escherichia coli, GI1786345, Length=232, Percent_Identity=34.9137931034483, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786803, Length=241, Percent_Identity=31.5352697095436, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790739, Length=245, Percent_Identity=29.3877551020408, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1789593, Length=229, Percent_Identity=30.1310043668122, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87081791, Length=260, Percent_Identity=26.9230769230769, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786253, Length=224, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789891, Length=231, Percent_Identity=31.1688311688312, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081782, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788165, Length=241, Percent_Identity=29.8755186721992, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788506, Length=211, Percent_Identity=30.8056872037915, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787105, Length=215, Percent_Identity=28.8372093023256, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788450, Length=220, Percent_Identity=29.5454545454545, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786398, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790467, Length=206, Percent_Identity=30.5825242718447, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788225, Length=211, Percent_Identity=25.5924170616114, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786703, Length=183, Percent_Identity=34.4262295081967, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786563, Length=195, Percent_Identity=31.2820512820513, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790544, Length=225, Percent_Identity=26.2222222222222, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787370, Length=208, Percent_Identity=28.8461538461538, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787712, Length=195, Percent_Identity=27.1794871794872, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71992285, Length=214, Percent_Identity=28.5046728971963, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25146777, Length=221, Percent_Identity=27.6018099547511, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BTUD_SALCH (Q57PU4)

Other databases:

- EMBL:   AE017220
- RefSeq:   YP_216348.1
- ProteinModelPortal:   Q57PU4
- SMR:   Q57PU4
- GeneID:   3333817
- GenomeReviews:   AE017220_GR
- KEGG:   sec:SC1361
- HOGENOM:   HBG758042
- OMA:   VWHYLAL
- ProtClustDB:   PRK03695
- BioCyc:   SENT321314:SCH_1361-MONOMER
- BRENDA:   3.6.3.33
- HAMAP:   MF_01005
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- SMART:   SM00382

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.33

Molecular weight: Translated: 27110; Mature: 26978

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLMQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGG
CCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEECC
APLEAWATATLAQHRAYLAQQQNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKL
CCHHHHHHHHHHHHHHHHHHCCCCCEECHHHHEEEEECCCCCCCCCHHHHHHHHCCCHHH
GRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSLDVAQQNALDRVLHHLC
HHHHHHCCCCCHHHHEEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
QAGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVE
HHCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHCCEEEEECCC
GHPMLISAT
CCCEEEEEC
>Mature Secondary Structure 
SQLMQLKDVAESTRLGPLSGEVSAGEILHLVGPNGAGKSTLLARMAGLTSGEGSIRFGG
CHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEECC
APLEAWATATLAQHRAYLAQQQNPPFAMPVWHYLTLHQPDKTRTGQLNEVADMLGLGDKL
CCHHHHHHHHHHHHHHHHHHCCCCCEECHHHHEEEEECCCCCCCCCHHHHHHHHCCCHHH
GRSVNQLSGGEWQRVRLAAVVLQIHPDANPVGQLLLLDEPMNSLDVAQQNALDRVLHHLC
HHHHHHCCCCCHHHHEEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
QAGIAIVMSSHDLNHTLRHAHKAWLLKRGKLIACGRREEVLTPSYLAQAYGLRFRRLDVE
HHCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHCCEEEEECCC
GHPMLISAT
CCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA