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The map label for this gene is ndk [H]

Identifier: 29140862

GI number: 29140862

Start: 380126

End: 380557

Strand: Direct

Name: ndk [H]

Synonym: t0330

Alternate gene names: 29140862

Gene position: 380126-380557 (Clockwise)

Preceding gene: 29140861

Following gene: 29140863

Centisome position: 7.93

GC content: 55.32

Gene sequence:

>432_bases
ATGGCTATTGAACGGACTTTTTCCATCATTAAACCCAACGCGGTGGCAAAAAACGTTATTGGCAGCATCTTTGCGCGCTT
TGAAGCTGCAGGGTTCAAAATTGTTGGCACTAAAATGCTGCACCTGACCGTTGAGCAGGCGCGCGGCTTCTATGCTGAGC
ACGACGGCAAGCCGTTCTTTGACGGTCTGGTGGAGTTCATGACCTCTGGCCCTATCGTGGTATCCGTGCTGGAAAGTGAA
AATGCGGTACAGCGTCATCGCGATCTGCTTGGTGCCACCAATCCGGCGAACGCGTTGGCGGGGACGCTGCGTGCTGATTA
CGCTGACAGCCTGACCGAAAATGGCACCCACGGTTCGGATTCGCTGGAATCCGCGCAGCGCGAAATCGCCTTTTTCTTCG
GTGAAGGCGAAGTGTGCCCGCGCACCCGTTAA

Upstream 100 bases:

>100_bases
TTTATTTTAAAAAAATGTTACCTGCATCCATAGGCAATTGATGGGATGCTCTTTATAATCCGCGCCTGACATAACAACAG
AACATATTTCAGAGGTAAAC

Downstream 100 bases:

>100_bases
TCTCCTTCGTCTTTCACGCTGTAAATGCGTTGGCGATAAATTATCGGTTCAAATATTATTTTTGCTAATGCCGCGTGCAG
ACGTGGCATCCTTACGCCAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAIERTFSIIKPNAVAKNVIGSIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLESE
NAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSLESAQREIAFFFGEGEVCPRTR

Sequences:

>Translated_143_residues
MAIERTFSIIKPNAVAKNVIGSIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLESE
NAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSLESAQREIAFFFGEGEVCPRTR
>Mature_142_residues
AIERTFSIIKPNAVAKNVIGSIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLESEN
AVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSLESAQREIAFFFGEGEVCPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=45.2554744525547, Blast_Score=126, Evalue=5e-30,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=42.6470588235294, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=42.6470588235294, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=42.6470588235294, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=42.6470588235294, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=42.6470588235294, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=42.4460431654676, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI38045913, Length=130, Percent_Identity=43.8461538461538, Blast_Score=123, Evalue=5e-29,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=39.7058823529412, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI37574614, Length=144, Percent_Identity=35.4166666666667, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI7019465, Length=144, Percent_Identity=35.4166666666667, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI4505413, Length=145, Percent_Identity=39.3103448275862, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=33.5766423357664, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=34.0740740740741, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=96.5034965034965, Blast_Score=285, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=41.4814814814815, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=43.3823529411765, Blast_Score=127, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=45.3237410071942, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=38.2352941176471, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15522; Mature: 15390

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPNAVAKNVIGSIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFF
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCEEEECHHHHEEEHHHHCCCCCCCCCCHHH
DGLVEFMTSGPIVVSVLESENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
SLESAQREIAFFFGEGEVCPRTR
HHHHHHHHEEEEECCCCCCCCCC
>Mature Secondary Structure 
AIERTFSIIKPNAVAKNVIGSIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFF
CCCCCHHHHCCHHHHHHHHHHHHHHHHHCCEEEECHHHHEEEHHHHCCCCCCCCCCHHH
DGLVEFMTSGPIVVSVLESENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCH
SLESAQREIAFFFGEGEVCPRTR
HHHHHHHHEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA