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The map label for this gene is cadA [H]

Identifier: 29140831

GI number: 29140831

Start: 338668

End: 340812

Strand: Reverse

Name: cadA [H]

Synonym: t0297

Alternate gene names: 29140831

Gene position: 340812-338668 (Counterclockwise)

Preceding gene: 29140832

Following gene: 29140830

Centisome position: 7.11

GC content: 49.46

Gene sequence:

>2145_bases
ATGAACGTTATTGCTATCATGAACCACATGGGCGTCTACTTTAAAGAAGAGCCTATTCGTGAACTGCATCGTGCACTGGA
AGGTTTAAATTTCCGTATCGTCTATCCAAACGACCGAGAAGACCTGCTGAAGCTGATTGAAAATAACTCCCGCCTTTGCG
GCGTCATTTTCGACTGGGATAAATATAACCTTGAGCTTTGCGAAGAGATTAGCAAGCTGAACGAGTATATGCCGCTGTAT
GCCTTCGCCAACAGCTACTCTACGCTGGACGTCAGCCTCAACGATCTGAGAATGCAGGTTCGCTTCTTTGAATATGCTTT
AGGCGCCGCAGCCGATATCGCGGCGAAAATTCGCCAGAATACCGATGAATACATCGACAATATTCTGCCGCCGCTGACAA
AAGCACTGTTCAAATATGTGCGCGAAGGGAAATACACTTTCTGTACGCCTGGCCACATGGGCGGTACTGCTTTCCAGAAA
AGCCCCGTCGGCAGCATCTTTTATGATTTCTTCGGCCCGAACACGATGAAATCCGATATTTCGATTTCCGTTTCCGAACT
GGGTTCGCTGCTGGACCACTCCGGCCCGCATAAAGAAGCGGAAGAGTATATCGCCCGCGTCTTTAACGCCGAACGTAGCT
ACATGGTGACGAACGGCACCTCTACGGCGAACAAAATCGTCGGTATGTACTCCGCGCCGGCAGGCAGCACGGTACTGATT
GACCGTAACTGCCATAAATCGCTGACCCATCTGATGATGATGAGCGACATTACGCCGATTTATTTCCGCCCAACCCGTAA
CGCCTACGGTATTCTTGGCGGTATTCCGCAAAGCGAGTTCCAGCACGCCACTATCGCTAAACGGGTAAAAGAGACGCCTA
ACGCCACCTGGCCGGTCCATGCTGTTATTACTAACTCAACCTATGACGGTCTGTTGTATAACACTGACTACATCAAGAAA
ACTCTGGATGTGAAGTCCATTCATTTTGACTCCGCCTGGGTGCCTTACACCAATTTCTCCCCTATTTATCAGGGTAAATG
CGGTATGAGCGGCGACCGTGTAGAAGGCAAAATCATTTATGAAACCCAGTCCACGCATAAACTGCTGGCGGCGTTTTCAC
AGGCATCCATGATTCATGTTAAAGGCGACATTAACGAAGAAACCTTTAACGAAGCCTACATGATGCATACCACCACTTCT
CCGCACTACGGTATCGTAGCGTCTACTGAAACCGCAGCGGCGATGATGAAAGGTAATGCGGGTAAACGCCTGATTAACGG
CTCTATTGAACGTGCGATTAAATTCCGTAAAGAAATTAAACGCCTGAAAAGCGAATCTGACGGCTGGTTCTTTGACGTAT
GGCAGCCGGAACATATCGATGGAGCTGAGTGCTGGCCGCTGCGTTCAGATAGCGCATGGCATGGCTTCAAAAATATCGAT
AACGAACACATGTACCTCGACCCGATCAAAGTCACTATCCTGACGCCGGGGATGAAGAAAGACGGTACGATGGATGAATT
CGGTATTCCGGCAAGTCTGGTCGCCAAATATCTCGATGAACGCGGCATCATCGTAGAAAAAACCGGTCCATACAACCTGC
TGTTCCTGTTCAGCATTGGTATCGACAAAACCAAAGCTCTGAGCCTGCTGCGCGCGCTCACTGAATTTAAACGCGCCTTT
GACCTGAACCTGCGCGTCAAAAACATTCTGCCGGCACTGTATCGCGAAGCGCCTGAGTTTTATGAAAATATGCGCATCCA
GGAACTGGCGCAGAATATTCATAAACTGGTCGAACATCATAATCTGCCGGACTTAATGTACCGTGCGTTTGAAGTGCTGC
CGAAAATGGTGATGACGCCGTATACTGCGTTCCAGAAAGAGCTGCATGGCGAAACGGAAGAGGTGTATCTTGAAGAGATG
GTTGGACGCGTCAACGCCAACATGATCCTTCCTTACCCTCCGGGAGTGCCGCTGGTGATGCCTGGTGAAATGATCACCGA
GGAAAGCCGTCCGGTACTGGAATTCCTGCAAATGCTGTGCGAAATCGGCGCTCACTATCCGGGCTTCGAAACCGATATCC
ACGGCGCCTATCGTCAGGCTGACGGACGTTACACCGTTAAGGTGCTGAAAGAAAATACGAAATAA

Upstream 100 bases:

>100_bases
ACGGCTGAAGCGCTTTAACCGCTAACTCCTTTTTCTCAAAGCCCCTTTCGTCACCTGCTATAGCGTAGCGGGAGGGGCCC
ACTTTACCAGGAACAAGACT

Downstream 100 bases:

>100_bases
GTACCAAAGGGAAGTGGCTTGCCACTTCCCTTTTTTCACGCAGCAAGGAGACTTTATGAAAACACCCTCACAACCGCGCG
CGATTTTTTACATCGTGGCG

Product: lysine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MNVIAIMNHMGVYFKEEPIRELHRALEGLNFRIVYPNDREDLLKLIENNSRLCGVIFDWDKYNLELCEEISKLNEYMPLY
AFANSYSTLDVSLNDLRMQVRFFEYALGAAADIAAKIRQNTDEYIDNILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSIFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDYIKK
TLDVKSIHFDSAWVPYTNFSPIYQGKCGMSGDRVEGKIIYETQSTHKLLAAFSQASMIHVKGDINEETFNEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLKSESDGWFFDVWQPEHIDGAECWPLRSDSAWHGFKNID
NEHMYLDPIKVTILTPGMKKDGTMDEFGIPASLVAKYLDERGIIVEKTGPYNLLFLFSIGIDKTKALSLLRALTEFKRAF
DLNLRVKNILPALYREAPEFYENMRIQELAQNIHKLVEHHNLPDLMYRAFEVLPKMVMTPYTAFQKELHGETEEVYLEEM
VGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKENTK

Sequences:

>Translated_714_residues
MNVIAIMNHMGVYFKEEPIRELHRALEGLNFRIVYPNDREDLLKLIENNSRLCGVIFDWDKYNLELCEEISKLNEYMPLY
AFANSYSTLDVSLNDLRMQVRFFEYALGAAADIAAKIRQNTDEYIDNILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSIFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDYIKK
TLDVKSIHFDSAWVPYTNFSPIYQGKCGMSGDRVEGKIIYETQSTHKLLAAFSQASMIHVKGDINEETFNEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLKSESDGWFFDVWQPEHIDGAECWPLRSDSAWHGFKNID
NEHMYLDPIKVTILTPGMKKDGTMDEFGIPASLVAKYLDERGIIVEKTGPYNLLFLFSIGIDKTKALSLLRALTEFKRAF
DLNLRVKNILPALYREAPEFYENMRIQELAQNIHKLVEHHNLPDLMYRAFEVLPKMVMTPYTAFQKELHGETEEVYLEEM
VGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKENTK
>Mature_714_residues
MNVIAIMNHMGVYFKEEPIRELHRALEGLNFRIVYPNDREDLLKLIENNSRLCGVIFDWDKYNLELCEEISKLNEYMPLY
AFANSYSTLDVSLNDLRMQVRFFEYALGAAADIAAKIRQNTDEYIDNILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSIFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDYIKK
TLDVKSIHFDSAWVPYTNFSPIYQGKCGMSGDRVEGKIIYETQSTHKLLAAFSQASMIHVKGDINEETFNEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLKSESDGWFFDVWQPEHIDGAECWPLRSDSAWHGFKNID
NEHMYLDPIKVTILTPGMKKDGTMDEFGIPASLVAKYLDERGIIVEKTGPYNLLFLFSIGIDKTKALSLLRALTEFKRAF
DLNLRVKNILPALYREAPEFYENMRIQELAQNIHKLVEHHNLPDLMYRAFEVLPKMVMTPYTAFQKELHGETEEVYLEEM
VGRVNANMILPYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKENTK

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=714, Percent_Identity=92.436974789916, Blast_Score=1410, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=70.2816901408451, Blast_Score=1105, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=740, Percent_Identity=35.9459459459459, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI87082193, Length=645, Percent_Identity=32.8682170542636, Blast_Score=328, Evalue=8e-91,
Organism=Escherichia coli, GI1786909, Length=626, Percent_Identity=32.5878594249201, Blast_Score=310, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 81236; Mature: 81236

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIAIMNHMGVYFKEEPIRELHRALEGLNFRIVYPNDREDLLKLIENNSRLCGVIFDWD
CCEEEEEHHCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEEEEEECC
KYNLELCEEISKLNEYMPLYAFANSYSTLDVSLNDLRMQVRFFEYALGAAADIAAKIRQN
CCCHHHHHHHHHHHHCCCHHEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TDEYIDNILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSIFYDFFGPNTMKSDI
HHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
SISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
EEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTDYIKKTLDVKSIHFDSAWVPYTNFSPIYQGKCGMSGDRVEGKIIY
EEEECCCCCCEEEEHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDINEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNA
ECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEEECCCCCCEEEECCHHHHHHHCCCC
GKRLINGSIERAIKFRKEIKRLKSESDGWFFDVWQPEHIDGAECWPLRSDSAWHGFKNID
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEHMYLDPIKVTILTPGMKKDGTMDEFGIPASLVAKYLDERGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
IDKTKALSLLRALTEFKRAFDLNLRVKNILPALYREAPEFYENMRIQELAQNIHKLVEHH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPKMVMTPYTAFQKELHGETEEVYLEEMVGRVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKENTK
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCC
>Mature Secondary Structure
MNVIAIMNHMGVYFKEEPIRELHRALEGLNFRIVYPNDREDLLKLIENNSRLCGVIFDWD
CCEEEEEHHCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEEEEEECC
KYNLELCEEISKLNEYMPLYAFANSYSTLDVSLNDLRMQVRFFEYALGAAADIAAKIRQN
CCCHHHHHHHHHHHHCCCHHEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TDEYIDNILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSIFYDFFGPNTMKSDI
HHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
SISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
EEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTDYIKKTLDVKSIHFDSAWVPYTNFSPIYQGKCGMSGDRVEGKIIY
EEEECCCCCCEEEEHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDINEETFNEAYMMHTTTSPHYGIVASTETAAAMMKGNA
ECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEEECCCCCCEEEECCHHHHHHHCCCC
GKRLINGSIERAIKFRKEIKRLKSESDGWFFDVWQPEHIDGAECWPLRSDSAWHGFKNID
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEHMYLDPIKVTILTPGMKKDGTMDEFGIPASLVAKYLDERGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
IDKTKALSLLRALTEFKRAFDLNLRVKNILPALYREAPEFYENMRIQELAQNIHKLVEHH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPKMVMTPYTAFQKELHGETEEVYLEEMVGRVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKENTK
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]