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The map label for this gene is ldcC [H]

Identifier: 29140774

GI number: 29140774

Start: 273604

End: 275745

Strand: Direct

Name: ldcC [H]

Synonym: t0236

Alternate gene names: 29140774

Gene position: 273604-275745 (Clockwise)

Preceding gene: 29140773

Following gene: 29140775

Centisome position: 5.71

GC content: 52.01

Gene sequence:

>2142_bases
ATGAACATCATCGCCATTATGGGGCCGCACGGGGTTTATTATAAAGATGAACCCATCAAGGAGCTTGAGCGTGCATTACA
ATCCCTGGGATTTCAAATTATCTGGCCGCAAAATAGCGTTGACTTGTTGAAGTTTATTGAACATAACCCGCGCATCTGCG
GCGTTATTTTTGACTGGGATGAATACAGTCTCGACCTTTGTAGCGAAATCAACCAGCTAAATGAATACCTTCCTCTCTAC
GCCTTTATCAATACCAACTCCACGCTGGACGTTAGCGTTCACGATATGCGCATGGCGCTGTGGTTTTTTGAGTATGCATT
GGGGCTGGCTGAAGATATCGCGACGCGCATTCATCAATATACAAACGAATATCTCGATAATATTACGCCGCCGTTTACCA
AAGCGCTGTTTACCTACGCCAAAGAAGGAAAATATACCTTTTGTACGCCGGGGCATATGGCGGGAACGGTGTATCAGAAA
AGCCCGCCAGGCTGTCTGTTTTATGACTTTTTTGGCGGCAATACCTTAAAGGCCGATGTGTCGATTTCGGTGACTGAACT
GGGATCGCTGCTGGATCACACCGGGCCGCATCTGGAAGCGGAAGAGTATATCGCCCGTACTTTTGGCGCCGAGCAGAGTT
ATATGGTGACGAACGGTACGTCGACCTCGAATAAAATTGTCGGTATGTATGCCGCGCCTGCGGGAAGTACGCTACTTATT
GATCGTAATTGCCATAAATCGCTGGCGCATTTGCTGATGATGAGCGATGTGGTGCCTCTCTGGTTGAAGCCGACGCGCAA
TGCGCTCGGCATTCTCGGCGGTATTCCTAAGCGTGAATTTACCCGCGACAGCATTGCGCGTAAGGTGGCGGAAACCGCGC
AGGCGCAATGGCCGGTGCATGCGGTTATCACCAATTCGACTTACGATGGTCTGCTGTATAACACTAACTGGATCAAGCAG
ATGCTGGACGTTCCCTCGATCCATTTTGATTCCGCCTGGGTACCCTATACCCATTTCCATCCGATCTACCAGGGGAAAAG
CGGGATGAGCGGCGATCGGGTGCCCGGAAAAGTGATTTTCGAAACGCAATCCACCCATAAAATGCTGGCGGCTTTTTCGC
AGGCGTCGCTTATTCATATCAAAGGGGAATATGACGAAGAGACGTTTAACGAAGCGTTTATGATGCACACTTCTACATCG
CCGAGCTATCCCATTGTCGCCTCTATCGAGACCGCGGCGGCGATGCTGCGCGGCAATCCAGGGAAAAGATTGATTAATCG
TTCGGTGGAACGGGCGCTCCATTTTCGTAAAGAAGTACAGCGGTTACGTGAAGAGTCCGATAGCTGGTTCTTTGATATCT
GGCAGCCGGAAGAGGTTGATGAGGCCGAATGCTGGCCGGTCACGCCGGGAGAAACCTGGCATGGCTTCACCGATGCTGAT
GACGATCATATGTTCCTCGATCCGGTTAAGGTGACAATCCTGACGCCGGGGATGGATGAACAGGGCAACATGAGCGAAGA
GGGGATACCCGCCGCGCTGGTGGCGAAGTTCCTCGATGAGCGAGGCGTGGTGGTGGAAAAAACCGGGCCGTATAATCTGC
TGTTTTTGTTCAGCATAGGGATTGATAAGACCCGTGCGATGGGGCTGCTGCGCGGACTGACGGAATTTAAACGCGCCTAC
GATCTTAACCTGCGCGTCAAAAATATGTTGCCGGATCTGTATGCGGAAGATCCGGATTTTTATCGCAATATGCGCATTCA
GGATCTGGCGCAGGGGATCCATAAACTGATCCGCCAGCACGATCTTCCGGAGCTGATGCTGCGGGCGTTCGAGGTTTTAC
CGGAGATGATCATGACCCCGCACCAGGCCTGGCAGCGTCAGATCAAAGGTGAGGTGGAAACCGTGGCGCTCGATCAACTG
CCAGGGCGCGTTTCCGCGAATATGATCCTGCCTTATCCGCCAGGCGTTCCGCTGTTGATGCCCGGCGAGAGGATCACGCA
ACAGAGTCGGGCCGTGCTCGATTTTCTGCTGATGCTCTGTTCGATTGGCCAGCATTATCCCGGTTTTGAAACGGATATTC
ACGGCGCGAAACGGAATGAAGACGGGGTGTACCAGGTACGAGTCTTAAAACACGCCTGTTAG

Upstream 100 bases:

>100_bases
GGCCGATGCATGGAACGCATTGTAATAAGATAAATCCTGTCGGTGCTTTGCATCGGCAGGATTGTTACTATGCTTATCTC
AGGTTTTTTCAGGAGAAAGC

Downstream 100 bases:

>100_bases
CTTGCCTGACGAGAATGTGACGAGTAACGTACTGATAATCAATAAAGGAGACGCTATGCTGGGATTAAAACAGGTTCATC
ACATCGCGATCATTGCGACA

Product: lysine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSEINQLNEYLPLY
AFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQYTNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTVYQK
SPPGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPKREFTRDSIARKVAETAQAQWPVHAVITNSTYDGLLYNTNWIKQ
MLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIFETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQHDLPELMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQL
PGRVSANMILPYPPGVPLLMPGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC

Sequences:

>Translated_713_residues
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSEINQLNEYLPLY
AFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQYTNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTVYQK
SPPGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPKREFTRDSIARKVAETAQAQWPVHAVITNSTYDGLLYNTNWIKQ
MLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIFETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQHDLPELMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQL
PGRVSANMILPYPPGVPLLMPGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC
>Mature_713_residues
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSEINQLNEYLPLY
AFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQYTNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTVYQK
SPPGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPKREFTRDSIARKVAETAQAQWPVHAVITNSTYDGLLYNTNWIKQ
MLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIFETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTS
PSYPIVASIETAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIGIDKTRAMGLLRGLTEFKRAY
DLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQHDLPELMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQL
PGRVSANMILPYPPGVPLLMPGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC

Specific function: LDC is constitutively but weakly expressed under various conditions [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=712, Percent_Identity=91.0112359550562, Blast_Score=1374, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=710, Percent_Identity=70.8450704225352, Blast_Score=1104, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=720, Percent_Identity=34.8611111111111, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI87082193, Length=620, Percent_Identity=34.5161290322581, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1786909, Length=696, Percent_Identity=32.0402298850575, Blast_Score=308, Evalue=8e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80793; Mature: 80793

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSEINQLNEYLPLYAFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQY
CCCHHHHHHHHHHHHCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTVYQKSPPGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPKREFTRDSIARKVAETAQAQWPVH
ECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
AVITNSTYDGLLYNTNWIKQMLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIF
EEEECCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTSPSYPIVASIETAAAMLRGNP
ECCHHHHHHHHHCCCEEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLPELMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQLPGRVSANMILPYPPGVPLLM
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCCCCCEEC
PGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHCC
>Mature Secondary Structure
MNIIAIMGPHGVYYKDEPIKELERALQSLGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSEINQLNEYLPLYAFINTNSTLDVSVHDMRMALWFFEYALGLAEDIATRIHQY
CCCHHHHHHHHHHHHCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNEYLDNITPPFTKALFTYAKEGKYTFCTPGHMAGTVYQKSPPGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLAHLLMMSDVVPLWLKPTRNALGILGGIPKREFTRDSIARKVAETAQAQWPVH
ECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
AVITNSTYDGLLYNTNWIKQMLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGDRVPGKVIF
EEEECCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTSTSPSYPIVASIETAAAMLRGNP
ECCHHHHHHHHHCCCEEEEEECCCCHHHHCCEEEEEECCCCCCCEEEEHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDSWFFDIWQPEEVDEAECWPVTPGETWHGFTDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
DDHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTRAMGLLRGLTEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRQH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLPELMLRAFEVLPEMIMTPHQAWQRQIKGEVETVALDQLPGRVSANMILPYPPGVPLLM
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEEEHHCCCCCCCCCEEEECCCCCCEEC
PGERITQQSRAVLDFLLMLCSIGQHYPGFETDIHGAKRNEDGVYQVRVLKHAC
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226257; 9339543; 9278503; 9723924 [H]