Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 29140750

GI number: 29140750

Start: 241491

End: 242918

Strand: Direct

Name: htrA [H]

Synonym: t0210

Alternate gene names: 29140750

Gene position: 241491-242918 (Clockwise)

Preceding gene: 29140749

Following gene: 29140751

Centisome position: 5.04

GC content: 55.04

Gene sequence:

>1428_bases
ATGAAAAAAACCACATTAGCAATGAGTGCACTGGCTCTGAGTTTAGGTTTGGCATTGTCGCCTCTGTCTGCCACGGCGGC
TGAAACGTCCTCTTCAGCAATGACTGCCCAGCAGATGCCAAGCCTGGCACCGATGCTCGAAAAAGTGATGCCATCGGTGG
TCAGTATTAATGTAGAAGGTAGCACCACGGTGAATACGCCGCGTATGCCGCGTAATTTCCAGCAATTCTTTGGCGATGAC
TCCCCGTTCTGCCAGGACGGTTCTCCGTTCCAGAATTCTCCGTTCTGCCAGGGCGGCGGTAACGGCGGCAACGGCGGTCA
ACAACAGAAATTCATGGCGCTGGGCTCCGGCGTAATTATTGACGCCGCGAAGGGCTACGTCGTCACCAACAACCACGTGG
TTGATAACGCCAGCGTGATTAAAGTACAGCTTAGCGATGGGCGTAAATTCGATGCTAAAGTGGTGGGCAAAGATCCGCGT
TCTGATATCGCGCTGATTCAAATTCAGAATCCGAAGAACCTGACGGCGATTAAGCTGGCGGACTCCGACGCGCTGCGCGT
GGGGGATTATACCGTCGCTATTGGTAACCCGTTTGGTCTGGGCGAAACGGTGACGTCAGGTATCGTTTCGGCGCTGGGGC
GTAGCGGCCTGAACGTAGAAAATTACGAGAACTTTATTCAGACCGACGCCGCGATTAACCGCGGTAACTCCGGCGGCGCG
CTGGTGAACCTGAACGGTGAGCTGATCGGTATTAACACCGCGATTCTGGCGCCGGACGGCGGCAACATCGGTATCGGCTT
CGCTATCCCCAGTAACATGGTGAAAAACCTGACGTCGCAGATGGTGGAATACGGCCAGGTGAAACGCGGCGAACTGGGGA
TCATGGGGACTGAGCTGAGCTCTGAGCTGGCGAAAGCGATGAAAGTCGACGCCCAGCGTGGCGCGTTCGTCAGCCAGGTG
ATGCCGAATTCGTCCGCAGCGAAAGCGGGTATCAAAGCCGGGGATGTCATTACCTCGCTGAACGGTAAACCGATCAGCAG
CTTTGCGGCGCTGCGCGCTCAGGTCGGCACTATGCCGGTCGGCAGCAAAATCAGCCTCGGTCTGCTGCGTGAAGGTAAAG
CGATTACGGTTAATCTGGAACTGCAGCAGAGCAGCCAGAGTCAGGTTGATTCCAGCACCATCTTCAGCGGGATTGAGGGC
GCTGAAATGAGTAATAAAGGCCAGGATAAAGGCGTTGTGGTGAGCAGCGTGAAAGCGAACTCACCCGCCGCGCAAATTGG
CCTCAAAAAAGGCGATGTGATTATCGGCGCTAACCAGCAGCCGGTGAAAAATATCGCCGAGCTGCGTAAGATTCTCGACA
GCAAGCCGTCGGTGCTGGCGCTGAATATTCAGCGTGGTGATAGTTCTATTTATTTGCTGATGCAGTAA

Upstream 100 bases:

>100_bases
TTTTACTTTTTCCAGAAACTTTATTCCGGAACTTCGCGTTATAAAATGAATCTGACGTACACAGCAATTTTGCGTTACCT
GTTAATCGAGATTGAAACAC

Downstream 100 bases:

>100_bases
TCACCTTTGTCCCCCTTCCACCACGGAAGGGGGCAACACTTTTCTGTGAAACTCCCCACAACTCCATACTTCTTTGCACC
GTTTTGTGCATTTGCACAAT

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKKTTLAMSALALSLGLALSPLSATAAETSSSAMTAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDD
SPFCQDGSPFQNSPFCQGGGNGGNGGQQQKFMALGSGVIIDAAKGYVVTNNHVVDNASVIKVQLSDGRKFDAKVVGKDPR
SDIALIQIQNPKNLTAIKLADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGA
LVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELSSELAKAMKVDAQRGAFVSQV
MPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKISLGLLREGKAITVNLELQQSSQSQVDSSTIFSGIEG
AEMSNKGQDKGVVVSSVKANSPAAQIGLKKGDVIIGANQQPVKNIAELRKILDSKPSVLALNIQRGDSSIYLLMQ

Sequences:

>Translated_475_residues
MKKTTLAMSALALSLGLALSPLSATAAETSSSAMTAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDD
SPFCQDGSPFQNSPFCQGGGNGGNGGQQQKFMALGSGVIIDAAKGYVVTNNHVVDNASVIKVQLSDGRKFDAKVVGKDPR
SDIALIQIQNPKNLTAIKLADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGA
LVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELSSELAKAMKVDAQRGAFVSQV
MPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKISLGLLREGKAITVNLELQQSSQSQVDSSTIFSGIEG
AEMSNKGQDKGVVVSSVKANSPAAQIGLKKGDVIIGANQQPVKNIAELRKILDSKPSVLALNIQRGDSSIYLLMQ
>Mature_475_residues
MKKTTLAMSALALSLGLALSPLSATAAETSSSAMTAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDD
SPFCQDGSPFQNSPFCQGGGNGGNGGQQQKFMALGSGVIIDAAKGYVVTNNHVVDNASVIKVQLSDGRKFDAKVVGKDPR
SDIALIQIQNPKNLTAIKLADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGA
LVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELSSELAKAMKVDAQRGAFVSQV
MPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKISLGLLREGKAITVNLELQQSSQSQVDSSTIFSGIEG
AEMSNKGQDKGVVVSSVKANSPAAQIGLKKGDVIIGANQQPVKNIAELRKILDSKPSVLALNIQRGDSSIYLLMQ

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=251, Percent_Identity=41.8326693227092, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI22129776, Length=263, Percent_Identity=38.0228136882129, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=36.6935483870968, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7019477, Length=264, Percent_Identity=37.1212121212121, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1786356, Length=475, Percent_Identity=92.6315789473684, Blast_Score=830, Evalue=0.0,
Organism=Escherichia coli, GI1789629, Length=478, Percent_Identity=56.9037656903766, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1789630, Length=348, Percent_Identity=38.5057471264368, Blast_Score=207, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24646839, Length=253, Percent_Identity=37.9446640316205, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49289; Mature: 49289

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTTLAMSALALSLGLALSPLSATAAETSSSAMTAQQMPSLAPMLEKVMPSVVSINVEG
CCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHCCHHHHHHHHHCCCEEEEEECC
STTVNTPRMPRNFQQFFGDDSPFCQDGSPFQNSPFCQGGGNGGNGGQQQKFMALGSGVII
CCEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCEEE
DAAKGYVVTNNHVVDNASVIKVQLSDGRKFDAKVVGKDPRSDIALIQIQNPKNLTAIKLA
ECCCCEEEECCEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEEE
DSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGA
CCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCE
LVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELS
EEEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECHHH
SELAKAMKVDAQRGAFVSQVMPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPV
HHHHHHHHHHHHCCCHHHHHCCCCCHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCC
GSKISLGLLREGKAITVNLELQQSSQSQVDSSTIFSGIEGAEMSNKGQDKGVVVSSVKAN
CCCEEEEEEECCCEEEEEEEECCCCCHHCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
SPAAQIGLKKGDVIIGANQQPVKNIAELRKILDSKPSVLALNIQRGDSSIYLLMQ
CCHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
>Mature Secondary Structure
MKKTTLAMSALALSLGLALSPLSATAAETSSSAMTAQQMPSLAPMLEKVMPSVVSINVEG
CCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHCCHHHHHHHHHCCCEEEEEECC
STTVNTPRMPRNFQQFFGDDSPFCQDGSPFQNSPFCQGGGNGGNGGQQQKFMALGSGVII
CCEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCEEE
DAAKGYVVTNNHVVDNASVIKVQLSDGRKFDAKVVGKDPRSDIALIQIQNPKNLTAIKLA
ECCCCEEEECCEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEEE
DSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGA
CCCCEEECCEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCE
LVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELS
EEEECCEEEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECHHH
SELAKAMKVDAQRGAFVSQVMPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPV
HHHHHHHHHHHHCCCHHHHHCCCCCHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCC
GSKISLGLLREGKAITVNLELQQSSQSQVDSSTIFSGIEGAEMSNKGQDKGVVVSSVKAN
CCCEEEEEEECCCEEEEEEEECCCCCHHCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
SPAAQIGLKKGDVIIGANQQPVKNIAELRKILDSKPSVLALNIQRGDSSIYLLMQ
CCHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]