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The map label for this gene is patA [H]

Identifier: 161486784

GI number: 161486784

Start: 3227676

End: 3229082

Strand: Direct

Name: patA [H]

Synonym: t3138

Alternate gene names: 161486784

Gene position: 3227676-3229082 (Clockwise)

Preceding gene: 29143475

Following gene: 29143480

Centisome position: 67.36

GC content: 54.44

Gene sequence:

>1407_bases
GTGATACACGGCCCTCTGGAGCTCATTTTGAACAGGTTACCTTCCAGCGCATCGGCTTTGGCCTGTAGCGCGCACGCACT
GAATCTCATCGAGAAGCGAACGCTAAACCATGAGGAAATGAAAGCACTAAACCGAGAGGTCATTGACTACTTTAAAGAGC
ATGTAAATCCAGGATTTCTGGAATACCGGAAATCTGTTACCGCCGGCGGGGATTACGGAGCCGTAGAGTGGCAAGCGGGC
AGTTTGAATACGCTTGTCGACACCCAGGGGCAGGAGTTTATCGATTGTCTTGGGGGGTTTGGCATCTTTAACGTGGGGCA
CCGTAATCCTGTTGTGGTATCCGCCGTCCAGAATCAACTCGCAAAACAACCTCTCCACAGCCAGGAGTTACTTGACCCCT
TGCGGGCGATGCTGGCAAAAACGCTGGCGGCGCTAACACCGGGGAAACTCAAGTACAGCTTTTTCTGTAACAGCGGCACC
GAATCCGTCGAAGCGGCGCTAAAACTGGCAAAAGCGTATCAGTCGCCGCGCGGCAAGTTTACCTTTATCGCCACCAGCGG
CGCATTTCACGGCAAATCATTGGGCGCGCTCTCCGCCACGGCCAAATCCACCTTCCGCAGACCCTTTATGCCTTTACTGC
CGGGCTTCCGCCATGTGCCGTTTGGCAATATCGACGCGATGAGCATGGCATTTAGCGAAGGCAAAAAAACGGGCGACGAG
ATAGCAGCCGTGATTCTGGAGCCTATTCAGGGTGAAGGCGGCGTGATCCTGCCGCCGCAGGGATACCTGACAGAGGTACG
TAAGCTCTGTGATGAATTCGGCGCGCTGATGATTCTGGATGAAGTACAAACCGGCATGGGGCGTACCGGCAAGATGTTTG
CCTGCGAGCACGAAAATGTGCAGCCTGATATTCTGTGTCTGGCGAAAGCCCTGGGCGGCGGCGTGATGCCAATTGGCGCC
ACCATCGCGACTGAGGAGGTGTTTTCGGTTCTGTTCGACAATCCCTTCCTGCATACCACCACTTTTGGCGGTAACCCGCT
GGCTTGTGCTGCCGCGCTGGCGACCATTAACGTCCTGCTGGAACAAAACCTCCCGGCCCAGGCGGAACAAAAAGGCGATA
CGCTCCTGGATGGTTTTCGACAACTTGCGCGTGAATATCCCAATCTGGTACACGAGGCGCGCGGCAAAGGTATGTTGATG
GCCATTGAATTTGTCGATAACGAAACGGGCTACCGTTTTGCCAGTGAGATGTTCCGTCAACGCGTGCTGGTCGCTGGTAC
GCTGAATAATGCGAAAACAATTCGTATCGAGCCACCGCTCACGCTAACCATTGAACTGTGCGAACAGGTATTGAAATCAG
CGCGTAATGCGCTGGCGGCAATGCAGGTGAGCGTTGAAGAGGTTTAA

Upstream 100 bases:

>100_bases
ATTAAATGTTGTGTAAATGTGATTATTCCTGGTGTTTATCCCGATTTTCACTATGGGCTTAGACCCCCGCTAATCCCTGC
AATACTTAATTCAGTATCAT

Downstream 100 bases:

>100_bases
AAACGATGCCGGATGGCGCTGTGCTTATCCGGCCTGTTTTCCCCGGGTCGCGGCCTCTTTTTTGAATCCCATCACAATCA
CCACATTCCCCTTTTCCCTT

Product: putrescine--2-oxoglutarate aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MIHGPLELILNRLPSSASALACSAHALNLIEKRTLNHEEMKALNREVIDYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAG
SLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGT
ESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRRPFMPLLPGFRHVPFGNIDAMSMAFSEGKKTGDE
IAAVILEPIQGEGGVILPPQGYLTEVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGA
TIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDTLLDGFRQLAREYPNLVHEARGKGMLM
AIEFVDNETGYRFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIELCEQVLKSARNALAAMQVSVEEV

Sequences:

>Translated_468_residues
MIHGPLELILNRLPSSASALACSAHALNLIEKRTLNHEEMKALNREVIDYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAG
SLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGT
ESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRRPFMPLLPGFRHVPFGNIDAMSMAFSEGKKTGDE
IAAVILEPIQGEGGVILPPQGYLTEVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGA
TIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDTLLDGFRQLAREYPNLVHEARGKGMLM
AIEFVDNETGYRFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIELCEQVLKSARNALAAMQVSVEEV
>Mature_468_residues
MIHGPLELILNRLPSSASALACSAHALNLIEKRTLNHEEMKALNREVIDYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAG
SLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGT
ESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRRPFMPLLPGFRHVPFGNIDAMSMAFSEGKKTGDE
IAAVILEPIQGEGGVILPPQGYLTEVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGA
TIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDTLLDGFRQLAREYPNLVHEARGKGMLM
AIEFVDNETGYRFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIELCEQVLKSARNALAAMQVSVEEV

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=368, Percent_Identity=34.5108695652174, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI284507298, Length=296, Percent_Identity=37.1621621621622, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI13994255, Length=461, Percent_Identity=30.8026030368764, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI37574042, Length=392, Percent_Identity=29.0816326530612, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI226442705, Length=392, Percent_Identity=28.8265306122449, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI24119277, Length=408, Percent_Identity=27.6960784313726, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442709, Length=372, Percent_Identity=29.3010752688172, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI188536080, Length=416, Percent_Identity=23.5576923076923, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI38679950, Length=416, Percent_Identity=23.5576923076923, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI38679946, Length=416, Percent_Identity=23.5576923076923, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI145693181, Length=458, Percent_Identity=94.5414847161572, Blast_Score=865, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=373, Percent_Identity=34.8525469168901, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=34.5588235294118, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789759, Length=330, Percent_Identity=36.0606060606061, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789016, Length=383, Percent_Identity=33.420365535248, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786991, Length=282, Percent_Identity=34.3971631205674, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1786349, Length=335, Percent_Identity=29.5522388059701, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=371, Percent_Identity=33.4231805929919, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25144274, Length=262, Percent_Identity=38.1679389312977, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32564660, Length=414, Percent_Identity=28.743961352657, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=417, Percent_Identity=27.3381294964029, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=23.2876712328767, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=387, Percent_Identity=36.4341085271318, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323470, Length=377, Percent_Identity=30.7692307692308, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=320, Percent_Identity=29.6875, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=366, Percent_Identity=23.224043715847, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357415, Length=385, Percent_Identity=32.7272727272727, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21356575, Length=413, Percent_Identity=30.9927360774818, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28574759, Length=442, Percent_Identity=28.7330316742081, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI161085790, Length=456, Percent_Identity=28.5087719298246, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281366494, Length=310, Percent_Identity=25.1612903225806, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667139, Length=310, Percent_Identity=25.1612903225806, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667143, Length=310, Percent_Identity=25.1612903225806, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 50696; Mature: 50696

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHGPLELILNRLPSSASALACSAHALNLIEKRTLNHEEMKALNREVIDYFKEHVNPGFL
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
EYRKSVTAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQL
HHHHHHCCCCCCCEEEEECCCCCHHHCCCCHHHHHHHCCCCEEECCCCCCEEHHHHHHHH
AKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKF
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCE
TFIATSGAFHGKSLGALSATAKSTFRRPFMPLLPGFRHVPFGNIDAMSMAFSEGKKTGDE
EEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHH
IAAVILEPIQGEGGVILPPQGYLTEVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENV
HHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEEHHHHHCCCCCCCEEEECCCCC
QPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLL
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
EQNLPAQAEQKGDTLLDGFRQLAREYPNLVHEARGKGMLMAIEFVDNETGYRFASEMFRQ
HCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHH
RVLVAGTLNNAKTIRIEPPLTLTIELCEQVLKSARNALAAMQVSVEEV
HHHEEEECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIHGPLELILNRLPSSASALACSAHALNLIEKRTLNHEEMKALNREVIDYFKEHVNPGFL
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
EYRKSVTAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQL
HHHHHHCCCCCCCEEEEECCCCCHHHCCCCHHHHHHHCCCCEEECCCCCCEEHHHHHHHH
AKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKF
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCE
TFIATSGAFHGKSLGALSATAKSTFRRPFMPLLPGFRHVPFGNIDAMSMAFSEGKKTGDE
EEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHH
IAAVILEPIQGEGGVILPPQGYLTEVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENV
HHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEEHHHHHCCCCCCCEEEECCCCC
QPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLL
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
EQNLPAQAEQKGDTLLDGFRQLAREYPNLVHEARGKGMLMAIEFVDNETGYRFASEMFRQ
HCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHH
RVLVAGTLNNAKTIRIEPPLTLTIELCEQVLKSARNALAAMQVSVEEV
HHHEEEECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA