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The map label for this gene is aidB [H]

Identifier: 161486769

GI number: 161486769

Start: 4578042

End: 4579682

Strand: Direct

Name: aidB [H]

Synonym: t4428

Alternate gene names: 161486769

Gene position: 4578042-4579682 (Clockwise)

Preceding gene: 29144672

Following gene: 29144676

Centisome position: 95.54

GC content: 56.86

Gene sequence:

>1641_bases
TTGAAGGAGGGAGACACCATGTCCTGGCAAACACATACCGTCTTTAATCAACCTGCTCCGCTCAATAACAGTAACTTATT
CCTGTCTGATGGCGCGCTGTGTGAAGCGGTTTCCCGGGAAGGCGCGGGATGGGATAGCGATCTTCTCGCCAGCATTGGCC
AACAACTGGGAACGGCGGAATCACTGGAACTGGGGCGTCTGGCGAACGCGCATCCTCCTGAGTTGCTGCGTTACGATCCC
CAGGGACAGCGCCTGGATGACGTTCGCTTTCATCCCGCCTGGCACCTGTTGATGCAGGGGCTTTGCGCTAATAGGGTACA
TTACCTGGCCTGGGAGGAAGAGGCAAGGGCGGGAAGTTTTGTCGCCCGGGCGGCGCGTTTTGTATTACATGCTCAGGTAG
AAGCGGGAACACTCTGTCCTGTCACGATGACCTTTGCCGCGACGCCGTTGCTATTGCAGATGCTTCCCGCCACTTTCCAT
GACTGGCTGGCGCCGCTGCGCAGCGATCGCTACGATTCGCATTTGCTGCCGGGCGGGCAAAAACGGGGCCTGCTCATCGG
CATGGGAATGACGGAAAAGCAGGGCGGATCTGACGTACTCAGTAATACGACCCACGCGGAGCGGCTGGCGGATGATTCAT
ATCGGCTGGTGGGACATAAATGGTTTTTCTCTGTGCCGCAAAGTGATGCGCACCTCGTGCTGGCGCAGGCAAAAGGAGGA
CTATCCTGTTTCTTTGTGCCGCGTTTCCTGCCAGACGGGCAACGGAACTCTGTTCGTCTTGAGCGCCTGAAAGATAAACT
CGGTAATCGATCTAATGCCAGCGCCGAGGTCGAGTTTCAGGATACCGTCGGCTGGCGGCTGGGAGAAGAGGGCGAAGGGA
TTCGGCATATCTTAAAGATGGGCGGTATGACGCGTCTTGATTGCGCGCTCGGGAGTCATGGCTTAATGCGGCGCGCATTT
TCAGTCGCCATTTACTATGCTCATCAGCGTCAGGCTTTTGGTAAGCCGCTGATCGAACAACCGTTGATGCGACAAACCTT
AAGTCGTATGGCGCTATGCCTGGAGGGGCAGACGGCGCTTTTGTTTCGGCTGGCGCGCGCCTGGGAGCAACGTCGCGAGG
CGAAAGAGGCATTATGGGCGCGATTATTCACGCCAGCGGCGAAATTCGCCATCTGTAAGCAGGGAATCCCTTTTGTGGCT
GAGGCGATGGAGGTTCTCGGCGGGATGGGGTATTGCGAAGAGAGCGAACTCCCGCGCCTGTACCGTGAAATGCCGGTGAA
CAGTATCTGGGAAGGTTCCGGCAATATCATGTGTCTGGATGTACTTCGGGTGCTGACAAAACAACACGGCGTCTATGACG
TATTGAGTGAAGCTTTTGCGGAAGTCAAAGGTCAGGATCGCCATTACGACCGCGCGGTACGCCAGCTACAGCAACGTTTA
CGCAAACCGGACGAAGCAATGGGCAGAGAGATTACGCAGCAGCTTTTCTTGCTGGGGTGCGGAGCGGAAATGCTGCGTCA
TGCCTCGCCGCCGCTGGCGCAAGCGTGGTGTCAGATGATGCTGGATACACGCGGCGAAATGCCGCTGCCTGCCCAGGTGC
AAAATGATTTACTGTTAAGGGCGACCGGGGGACTGCGGTAA

Upstream 100 bases:

>100_bases
TTCCCGTTTCGTCCCACATTATATTGCCGGTTAATCATACTTTTGTGATCTTGCTCCGGCGTCAATGGCGCAGTCATGAC
CATACTTGACTTCAGCGCCA

Downstream 100 bases:

>100_bases
CGTTTGGCCTGTAGTACATGCCATCCGGCGCGAGCCACGCGGCATCAGGCATAGAGTATCGCCTGTACGCGCCAGTTATT
CGACTGTTGTTCTTCATACA

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MKEGDTMSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGRLANAHPPELLRYDP
QGQRLDDVRFHPAWHLLMQGLCANRVHYLAWEEEARAGSFVARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFH
DWLAPLRSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGG
LSCFFVPRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDTVGWRLGEEGEGIRHILKMGGMTRLDCALGSHGLMRRAF
SVAIYYAHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVA
EAMEVLGGMGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRL
RKPDEAMGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR

Sequences:

>Translated_546_residues
MKEGDTMSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGRLANAHPPELLRYDP
QGQRLDDVRFHPAWHLLMQGLCANRVHYLAWEEEARAGSFVARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFH
DWLAPLRSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGG
LSCFFVPRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDTVGWRLGEEGEGIRHILKMGGMTRLDCALGSHGLMRRAF
SVAIYYAHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVA
EAMEVLGGMGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRL
RKPDEAMGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR
>Mature_546_residues
MKEGDTMSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGRLANAHPPELLRYDP
QGQRLDDVRFHPAWHLLMQGLCANRVHYLAWEEEARAGSFVARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFH
DWLAPLRSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGG
LSCFFVPRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDTVGWRLGEEGEGIRHILKMGGMTRLDCALGSHGLMRRAF
SVAIYYAHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVA
EAMEVLGGMGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRL
RKPDEAMGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=290, Percent_Identity=31.0344827586207, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI7656849, Length=269, Percent_Identity=28.6245353159851, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI226958412, Length=271, Percent_Identity=26.9372693726937, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI226958414, Length=271, Percent_Identity=26.9372693726937, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI187960098, Length=278, Percent_Identity=28.4172661870504, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4557231, Length=278, Percent_Identity=28.4172661870504, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4501859, Length=252, Percent_Identity=25.3968253968254, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI21361497, Length=266, Percent_Identity=27.4436090225564, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI87082384, Length=539, Percent_Identity=84.9721706864564, Blast_Score=958, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=332, Percent_Identity=26.2048192771084, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081958, Length=271, Percent_Identity=26.9372693726937, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=539, Percent_Identity=30.9833024118738, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI86563381, Length=539, Percent_Identity=30.9833024118738, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17538396, Length=271, Percent_Identity=29.520295202952, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=270, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=275, Percent_Identity=25.0909090909091, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=270, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551932, Length=292, Percent_Identity=24.3150684931507, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17505929, Length=290, Percent_Identity=26.2068965517241, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17570075, Length=279, Percent_Identity=25.089605734767, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=266, Percent_Identity=25.187969924812, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71990804, Length=206, Percent_Identity=27.6699029126214, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=325, Percent_Identity=27.0769230769231, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355753, Length=260, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646207, Length=274, Percent_Identity=26.2773722627737, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24660351, Length=275, Percent_Identity=26.9090909090909, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363737, Length=290, Percent_Identity=23.7931034482759, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666513, Length=277, Percent_Identity=24.5487364620939, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 61058; Mature: 61058

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEGDTMSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAE
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
SLELGRLANAHPPELLRYDPQGQRLDDVRFHPAWHLLMQGLCANRVHYLAWEEEARAGSF
HHHHHHCCCCCCHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHH
VARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFHDWLAPLRSDRYDSHLLPGGQ
HHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGG
CCCEEEECCCCCCCCCCHHHHCCHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEEECCCC
LSCFFVPRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDTVGWRLGEEGEGIRHILKM
CEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCHHHHHHHHH
GGMTRLDCALGSHGLMRRAFSVAIYYAHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTAL
CCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHH
LFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVAEAMEVLGGMGYCEESELPRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHH
YREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRL
HHHCCCCCEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RKPDEAMGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLR
CCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCEEEE
ATGGLR
ECCCCC
>Mature Secondary Structure
MKEGDTMSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAE
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
SLELGRLANAHPPELLRYDPQGQRLDDVRFHPAWHLLMQGLCANRVHYLAWEEEARAGSF
HHHHHHCCCCCCHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHH
VARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFHDWLAPLRSDRYDSHLLPGGQ
HHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGG
CCCEEEECCCCCCCCCCHHHHCCHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEEECCCC
LSCFFVPRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDTVGWRLGEEGEGIRHILKM
CEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCCCHHHHHHHHH
GGMTRLDCALGSHGLMRRAFSVAIYYAHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTAL
CCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHH
LFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVAEAMEVLGGMGYCEESELPRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHH
YREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRL
HHHCCCCCEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RKPDEAMGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLR
CCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCEEEE
ATGGLR
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]