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The map label for this gene is ydgF [H]

Identifier: 28378479

GI number: 28378479

Start: 1636247

End: 1637587

Strand: Direct

Name: ydgF [H]

Synonym: lp_1811

Alternate gene names: 28378479

Gene position: 1636247-1637587 (Clockwise)

Preceding gene: 28378477

Following gene: 28378480

Centisome position: 49.46

GC content: 47.28

Gene sequence:

>1341_bases
ATGGAAAATCAGCAACTTGCCCGTAAACTAAAACGCCGTCACGTGCAGATGATTGCGCTTGGTGGCGCGATTGGAACCGG
GCTCTTTTTAGGCTCCGGTTTAGCAATCAAACAGGCGGGGCCGTCGATCTTGTTGGCTTATGCCATTGGCGGTTTCTTCT
GTTACTTGATGATGCGAGCACTGGGCGAGCTATTATTGTCGGATACGCGTTTACATTCGTTTCTAGAATTCATTAATCGA
TATTTAGGTAAACGTTTCGAGTTTGCCATTGGGTGGACCTATTGGCTCTGCTGGATCAGTTTAGCTATGGCTGACTTGAC
TGCGAGTGGTATCTACATTCGTTACTGGTTTCCGTGGATCCCGCAGTGGGTGACACCCTTAATAATTATTTTGATTTTAT
TAGTATTCAATATGCTCTCCGTCAGTGCGTTTGGCGAATTAGAATATTGGTTTTCGATGATTAAAGTGGTGGCTATCATT
GCTTTGATCGTGACGGGGGCTATCTTGATTGGTTCATCGGCCCATGTCGGTGGGCAAACGGTCTCGGTGACAAATTTGGT
CAGTCACGGGGGCTTCTTCCCAACAGGCGTCCAGGGCTTCTTGATGTCATTTTCGCTCGTTATCTTTGCGTTTACAGGCA
TCGAAATGGTCGGAATTACAGCTGGGGAAGCCGAAAACCCAGAAAAAGAATTACCACGGGCCATCAATAGCTTACCCATT
CGAATCTCATTCTTCTACGTGGGCGCTTTATTCGTGATCATGGCAATTTATCCTTGGAATCAGATCACGACCAGTCAGTC
ACCCTTTGTGCAAGTTTTCAGCGACGTTGGGATCAAAGCCGCGGCCAGCATTATCAACTTCGTGGTTCTGACCGCGGCGC
TCTCGGCTTGTAATAGTGCCATCTTCAGTACGAGTCGAACACTATTTACACTTGCGCACGGTGACAACGCGCCGAAATGG
ATGGGAAAGGTCAATCGTTACAACGTTCCCGCCCGCTCATTGTTATTCTCATCATTGATCTTACTGGTGATCGTGGCGTT
GAATTACGTGATTCCAAGTACCGTCTTCACGTTGATCTCTAACGTGGCAACAACCAACTTCATCATTGTTTGGTGTGCCT
TGTTGGTGTGCCATTACGTTTACAAACGAACCACTGACAGTACGCATAATCCGTTTAAACTGCCCCTGTTCCCTGTTACC
AACATCGCGACCTTGGCCTTCTTTATCGCGGTGACGGTCGTCTTGTGCTTTGATCAAGTCAACCGTTGGGCAGTCATCGG
TTCAGTCGTTTGGTTCGTCATTTTATTAGTCATCGAACGAAGTATGCATCGCACCGTTTAA

Upstream 100 bases:

>100_bases
TGCACGGCGGATTATTTTATCATAAAATGAATGGACGTGAAAAAATCTGTATTTTTATGAAAATTATTATCAAATTGGAT
TAAAGGAAAGTTGAGGTCAT

Downstream 100 bases:

>100_bases
AAACGATAATTGTAATCACCGGTCATCAGTCTTGGTAAACCCAATTAGTTTACCAGCTAATGGCCGGCGATTTTTGTAAG
GTGCAATAATCACCCCTAAT

Product: amino acid transport protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MENQQLARKLKRRHVQMIALGGAIGTGLFLGSGLAIKQAGPSILLAYAIGGFFCYLMMRALGELLLSDTRLHSFLEFINR
YLGKRFEFAIGWTYWLCWISLAMADLTASGIYIRYWFPWIPQWVTPLIIILILLVFNMLSVSAFGELEYWFSMIKVVAII
ALIVTGAILIGSSAHVGGQTVSVTNLVSHGGFFPTGVQGFLMSFSLVIFAFTGIEMVGITAGEAENPEKELPRAINSLPI
RISFFYVGALFVIMAIYPWNQITTSQSPFVQVFSDVGIKAAASIINFVVLTAALSACNSAIFSTSRTLFTLAHGDNAPKW
MGKVNRYNVPARSLLFSSLILLVIVALNYVIPSTVFTLISNVATTNFIIVWCALLVCHYVYKRTTDSTHNPFKLPLFPVT
NIATLAFFIAVTVVLCFDQVNRWAVIGSVVWFVILLVIERSMHRTV

Sequences:

>Translated_446_residues
MENQQLARKLKRRHVQMIALGGAIGTGLFLGSGLAIKQAGPSILLAYAIGGFFCYLMMRALGELLLSDTRLHSFLEFINR
YLGKRFEFAIGWTYWLCWISLAMADLTASGIYIRYWFPWIPQWVTPLIIILILLVFNMLSVSAFGELEYWFSMIKVVAII
ALIVTGAILIGSSAHVGGQTVSVTNLVSHGGFFPTGVQGFLMSFSLVIFAFTGIEMVGITAGEAENPEKELPRAINSLPI
RISFFYVGALFVIMAIYPWNQITTSQSPFVQVFSDVGIKAAASIINFVVLTAALSACNSAIFSTSRTLFTLAHGDNAPKW
MGKVNRYNVPARSLLFSSLILLVIVALNYVIPSTVFTLISNVATTNFIIVWCALLVCHYVYKRTTDSTHNPFKLPLFPVT
NIATLAFFIAVTVVLCFDQVNRWAVIGSVVWFVILLVIERSMHRTV
>Mature_446_residues
MENQQLARKLKRRHVQMIALGGAIGTGLFLGSGLAIKQAGPSILLAYAIGGFFCYLMMRALGELLLSDTRLHSFLEFINR
YLGKRFEFAIGWTYWLCWISLAMADLTASGIYIRYWFPWIPQWVTPLIIILILLVFNMLSVSAFGELEYWFSMIKVVAII
ALIVTGAILIGSSAHVGGQTVSVTNLVSHGGFFPTGVQGFLMSFSLVIFAFTGIEMVGITAGEAENPEKELPRAINSLPI
RISFFYVGALFVIMAIYPWNQITTSQSPFVQVFSDVGIKAAASIINFVVLTAALSACNSAIFSTSRTLFTLAHGDNAPKW
MGKVNRYNVPARSLLFSSLILLVIVALNYVIPSTVFTLISNVATTNFIIVWCALLVCHYVYKRTTDSTHNPFKLPLFPVT
NIATLAFFIAVTVVLCFDQVNRWAVIGSVVWFVILLVIERSMHRTV

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=334, Percent_Identity=23.9520958083832, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790653, Length=438, Percent_Identity=46.3470319634703, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1786302, Length=436, Percent_Identity=41.0550458715596, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=39.7321428571429, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI48994972, Length=425, Percent_Identity=41.6470588235294, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1786602, Length=441, Percent_Identity=45.3514739229025, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI87081915, Length=442, Percent_Identity=39.5927601809955, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI87081708, Length=431, Percent_Identity=35.9628770301624, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788480, Length=428, Percent_Identity=35.2803738317757, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=32.3255813953488, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17531343, Length=396, Percent_Identity=22.4747474747475, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=440, Percent_Identity=31.8181818181818, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6320772, Length=428, Percent_Identity=32.2429906542056, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=414, Percent_Identity=32.6086956521739, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=414, Percent_Identity=30.9178743961353, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=394, Percent_Identity=29.6954314720812, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=29, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6324553, Length=392, Percent_Identity=31.1224489795918, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=437, Percent_Identity=31.1212814645309, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319824, Length=396, Percent_Identity=26.5151515151515, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=397, Percent_Identity=26.448362720403, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6320251, Length=395, Percent_Identity=26.5822784810127, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=414, Percent_Identity=25.3623188405797, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=26.0651629072682, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=416, Percent_Identity=24.7596153846154, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319543, Length=397, Percent_Identity=24.9370277078086, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=481, Percent_Identity=28.0665280665281, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=26.3819095477387, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=345, Percent_Identity=26.9565217391304, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49390; Mature: 49390

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENQQLARKLKRRHVQMIALGGAIGTGLFLGSGLAIKQAGPSILLAYAIGGFFCYLMMRA
CCCHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
LGELLLSDTRLHSFLEFINRYLGKRFEFAIGWTYWLCWISLAMADLTASGIYIRYWFPWI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHH
PQWVTPLIIILILLVFNMLSVSAFGELEYWFSMIKVVAIIALIVTGAILIGSSAHVGGQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VSVTNLVSHGGFFPTGVQGFLMSFSLVIFAFTGIEMVGITAGEAENPEKELPRAINSLPI
EHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHEEEEECCCCCCCHHHHHHHHCCCCH
RISFFYVGALFVIMAIYPWNQITTSQSPFVQVFSDVGIKAAASIINFVVLTAALSACNSA
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IFSTSRTLFTLAHGDNAPKWMGKVNRYNVPARSLLFSSLILLVIVALNYVIPSTVFTLIS
HHHCCCCEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVATTNFIIVWCALLVCHYVYKRTTDSTHNPFKLPLFPVTNIATLAFFIAVTVVLCFDQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NRWAVIGSVVWFVILLVIERSMHRTV
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENQQLARKLKRRHVQMIALGGAIGTGLFLGSGLAIKQAGPSILLAYAIGGFFCYLMMRA
CCCHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
LGELLLSDTRLHSFLEFINRYLGKRFEFAIGWTYWLCWISLAMADLTASGIYIRYWFPWI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHH
PQWVTPLIIILILLVFNMLSVSAFGELEYWFSMIKVVAIIALIVTGAILIGSSAHVGGQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VSVTNLVSHGGFFPTGVQGFLMSFSLVIFAFTGIEMVGITAGEAENPEKELPRAINSLPI
EHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHEEEEECCCCCCCHHHHHHHHCCCCH
RISFFYVGALFVIMAIYPWNQITTSQSPFVQVFSDVGIKAAASIINFVVLTAALSACNSA
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IFSTSRTLFTLAHGDNAPKWMGKVNRYNVPARSLLFSSLILLVIVALNYVIPSTVFTLIS
HHHCCCCEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVATTNFIIVWCALLVCHYVYKRTTDSTHNPFKLPLFPVTNIATLAFFIAVTVVLCFDQV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NRWAVIGSVVWFVILLVIERSMHRTV
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]