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The map label for this gene is ung

Identifier: 28377657

GI number: 28377657

Start: 747476

End: 748168

Strand: Direct

Name: ung

Synonym: lp_0806

Alternate gene names: 28377657

Gene position: 747476-748168 (Clockwise)

Preceding gene: 28377654

Following gene: 28377658

Centisome position: 22.59

GC content: 46.32

Gene sequence:

>693_bases
ATGAAAGCGTTTATTCACACGGACTGGTGGGACGTCTTAAAACCAGAGTTTGAGAAGCCGTATTACCACCAATTACACGA
ATTTTTGAAAAATGAATACCGAACGAAAAATATTCACCCAGATATGTATAATATTTTTCAGGCCTTTGAATGGACGCCAT
TTGCTGACACGAAGGTCGTTATTTTAGGTCAGGATCCGTATCATGGTCCTGGTCAGGCACACGGACTGAGTTTTTCAGTG
TTACCGGGCGTGGCAGTGCCCCCATCACTAGTCAATATCTATAAAGAATTGCAAGATGATGTTGGGTGTACGCCCGTCAA
CCACGGTTACTTGGAAAGTTGGGCCAAGCAGGGAGTCTTGTTATTGAACTCCGTGCTGACTGTTCAAAATGGTGTGGCCT
TTTCACACGCTGGTAAGGGCTGGGAACGACTTACGGACGTTGCCATTCAGCGTTTATCGGAACGATCGACGCCGGTTGTC
TTTATCTTGTGGGGTAAGGCGGCTCGGTCCAAGATTAAGCTGATTGATACCCAGACGAATGTCGTGCTACAAGCACCTCA
TCCGAGTCCGCTTTCAGCTTATCGCGGATTCTTTGGGTCCAAACCATTTTCAAAAACGAACATTGCGTTAACATCCTTCG
GCGAACAGCCAATCAATTGGCAGTTACCAGAGCACGTCAATCTTGAGCATTAA

Upstream 100 bases:

>100_bases
GTTGTTTTAATAATTACATTCTAACATGTTTACGTCTGAATACAGAATTATTATCATTAGTGGTTTTGGTTATGATACAA
TAAAACGAGAGGTGTTAAGG

Downstream 100 bases:

>100_bases
TTAATTTATTGGAGGGTTATCACATGGATTTATTTGAGTCATTAGCACAAAAAATTACTGGTAAAGATCAAACAATTGTT
TTCCCTGAAGGAACTGAACC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKAFIHTDWWDVLKPEFEKPYYHQLHEFLKNEYRTKNIHPDMYNIFQAFEWTPFADTKVVILGQDPYHGPGQAHGLSFSV
LPGVAVPPSLVNIYKELQDDVGCTPVNHGYLESWAKQGVLLLNSVLTVQNGVAFSHAGKGWERLTDVAIQRLSERSTPVV
FILWGKAARSKIKLIDTQTNVVLQAPHPSPLSAYRGFFGSKPFSKTNIALTSFGEQPINWQLPEHVNLEH

Sequences:

>Translated_230_residues
MKAFIHTDWWDVLKPEFEKPYYHQLHEFLKNEYRTKNIHPDMYNIFQAFEWTPFADTKVVILGQDPYHGPGQAHGLSFSV
LPGVAVPPSLVNIYKELQDDVGCTPVNHGYLESWAKQGVLLLNSVLTVQNGVAFSHAGKGWERLTDVAIQRLSERSTPVV
FILWGKAARSKIKLIDTQTNVVLQAPHPSPLSAYRGFFGSKPFSKTNIALTSFGEQPINWQLPEHVNLEH
>Mature_230_residues
MKAFIHTDWWDVLKPEFEKPYYHQLHEFLKNEYRTKNIHPDMYNIFQAFEWTPFADTKVVILGQDPYHGPGQAHGLSFSV
LPGVAVPPSLVNIYKELQDDVGCTPVNHGYLESWAKQGVLLLNSVLTVQNGVAFSHAGKGWERLTDVAIQRLSERSTPVV
FILWGKAARSKIKLIDTQTNVVLQAPHPSPLSAYRGFFGSKPFSKTNIALTSFGEQPINWQLPEHVNLEH

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=50, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=49.7674418604651, Blast_Score=199, Evalue=1e-51,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=54.6728971962617, Blast_Score=231, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17556304, Length=215, Percent_Identity=48.8372093023256, Blast_Score=193, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6323620, Length=240, Percent_Identity=42.5, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_LACPL (Q88YG1)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784549.1
- ProteinModelPortal:   Q88YG1
- SMR:   Q88YG1
- GeneID:   1063885
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0806
- NMPDR:   fig|220668.1.peg.683
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   LPLA220668:LP_0806-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26076; Mature: 26076

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFIHTDWWDVLKPEFEKPYYHQLHEFLKNEYRTKNIHPDMYNIFQAFEWTPFADTKVV
CCCEEECCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEE
ILGQDPYHGPGQAHGLSFSVLPGVAVPPSLVNIYKELQDDVGCTPVNHGYLESWAKQGVL
EECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHH
LLNSVLTVQNGVAFSHAGKGWERLTDVAIQRLSERSTPVVFILWGKAARSKIKLIDTQTN
HHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCC
VVLQAPHPSPLSAYRGFFGSKPFSKTNIALTSFGEQPINWQLPEHVNLEH
EEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKAFIHTDWWDVLKPEFEKPYYHQLHEFLKNEYRTKNIHPDMYNIFQAFEWTPFADTKVV
CCCEEECCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEE
ILGQDPYHGPGQAHGLSFSVLPGVAVPPSLVNIYKELQDDVGCTPVNHGYLESWAKQGVL
EECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHH
LLNSVLTVQNGVAFSHAGKGWERLTDVAIQRLSERSTPVVFILWGKAARSKIKLIDTQTN
HHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCC
VVLQAPHPSPLSAYRGFFGSKPFSKTNIALTSFGEQPINWQLPEHVNLEH
EEEECCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566