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The map label for this gene is luxS

Identifier: 28377630

GI number: 28377630

Start: 710128

End: 710604

Strand: Direct

Name: luxS

Synonym: lp_0774

Alternate gene names: 28377630

Gene position: 710128-710604 (Clockwise)

Preceding gene: 28377629

Following gene: 28377631

Centisome position: 21.47

GC content: 42.56

Gene sequence:

>477_bases
ATGGCTAAAGTAGAAAGTTTTACATTAGATCATACCAAGGTTTTAGCACCTTACGTTCGTAAAATTACGGTGGAAAATGG
GCCTAAGGGTGATGCCATCACTAATTTTGATTTGCGGTTAGTTCAACCTAACAAGACCGCTATTGATACGGCGGGCTTAC
ACACGATTGAACATATGTTGGCTGGATTATTACGTGATCGGATGGATGGCGTGATTGACTGCTCACCATTTGGTTGTCGG
ACTGGTTTTCATTTGATTACTTGGGGTGAACATGACACCGTTGAAGTTGCTAAGGCATTGAAGTCCTCATTAGAATTCAT
TGCTGGCCCAGCTAAGTGGGAAGACGTACAAGGGACGACCATCGATAGCTGTGGGAATTACAAGGATCATTCTTTATTCT
CAGCTAAGGAATGGGCCAAGTTGATTTTATCGCAAGGAATTTCATCGGATCCATTTGTACGCAAAGTCGTTGAATAG

Upstream 100 bases:

>100_bases
ACGGGATCGAGCACGTGAAGCAACTGCACCTGCTAAATAACGGGCAATGTGCTACACTTGAGTTTGTAATGTAATTTTAA
TTTAGAGGAGTTGTTTGTAC

Downstream 100 bases:

>100_bases
ACCAAAATATAAAAAGTAATGGTGGTGCCGGCCACCAATTAAAAAGAGCCTAGCTTTTCATAACGAAAAGCTAGGCTCCT
TTTTGCTGTTTACTGACATT

Product: S-ribosylhomocysteinase

Products: NA

Alternate protein names: AI-2 synthesis protein; Autoinducer-2 production protein luxS

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MAKVESFTLDHTKVLAPYVRKITVENGPKGDAITNFDLRLVQPNKTAIDTAGLHTIEHMLAGLLRDRMDGVIDCSPFGCR
TGFHLITWGEHDTVEVAKALKSSLEFIAGPAKWEDVQGTTIDSCGNYKDHSLFSAKEWAKLILSQGISSDPFVRKVVE

Sequences:

>Translated_158_residues
MAKVESFTLDHTKVLAPYVRKITVENGPKGDAITNFDLRLVQPNKTAIDTAGLHTIEHMLAGLLRDRMDGVIDCSPFGCR
TGFHLITWGEHDTVEVAKALKSSLEFIAGPAKWEDVQGTTIDSCGNYKDHSLFSAKEWAKLILSQGISSDPFVRKVVE
>Mature_157_residues
AKVESFTLDHTKVLAPYVRKITVENGPKGDAITNFDLRLVQPNKTAIDTAGLHTIEHMLAGLLRDRMDGVIDCSPFGCRT
GFHLITWGEHDTVEVAKALKSSLEFIAGPAKWEDVQGTTIDSCGNYKDHSLFSAKEWAKLILSQGISSDPFVRKVVE

Specific function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is ca

COG id: COG1854

COG function: function code T; LuxS protein involved in autoinducer AI2 synthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the luxS family

Homologues:

Organism=Escherichia coli, GI1789043, Length=151, Percent_Identity=40.3973509933775, Blast_Score=123, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LUXS_LACPL (Q88YI6)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784522.1
- ProteinModelPortal:   Q88YI6
- GeneID:   1063754
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0774
- NMPDR:   fig|220668.1.peg.656
- HOGENOM:   HBG347473
- OMA:   TTFDIRM
- ProtClustDB:   PRK02260
- BioCyc:   LPLA220668:LP_0774-MONOMER
- BRENDA:   4.4.1.21
- HAMAP:   MF_00091
- InterPro:   IPR011249
- InterPro:   IPR003815
- Gene3D:   G3DSA:3.30.1360.80
- PIRSF:   PIRSF006160
- PRINTS:   PR01487
- ProDom:   PD013172

Pfam domain/function: PF02664 LuxS; SSF63411 Metalloenz_metal-bd

EC number: =4.4.1.21

Molecular weight: Translated: 17428; Mature: 17297

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVESFTLDHTKVLAPYVRKITVENGPKGDAITNFDLRLVQPNKTAIDTAGLHTIEHML
CCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCEECCEEEEECCCCCCHHHHHHHHHHHHH
AGLLRDRMDGVIDCSPFGCRTGFHLITWGEHDTVEVAKALKSSLEFIAGPAKWEDVQGTT
HHHHHHHHCCEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
IDSCGNYKDHSLFSAKEWAKLILSQGISSDPFVRKVVE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCC
>Mature Secondary Structure 
AKVESFTLDHTKVLAPYVRKITVENGPKGDAITNFDLRLVQPNKTAIDTAGLHTIEHML
CCCCCCCCCHHHHHHHHHHHEECCCCCCCCCEECCEEEEECCCCCCHHHHHHHHHHHHH
AGLLRDRMDGVIDCSPFGCRTGFHLITWGEHDTVEVAKALKSSLEFIAGPAKWEDVQGTT
HHHHHHHHCCEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
IDSCGNYKDHSLFSAKEWAKLILSQGISSDPFVRKVVE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566