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The map label for this gene is dapA [H]

Identifier: 28199610

GI number: 28199610

Start: 2024342

End: 2025250

Strand: Reverse

Name: dapA [H]

Synonym: PD1737

Alternate gene names: 28199610

Gene position: 2025250-2024342 (Counterclockwise)

Preceding gene: 28199613

Following gene: 28199609

Centisome position: 80.37

GC content: 54.9

Gene sequence:

>909_bases
TTGTCACTTTCCGGGATTATTACTGCGCTGGTCACTCCGTTTGATCGAGATGGTGCGTTTGACCGTGATGCGTGGATTCG
TCTGCTGGATATGCAATTAGCGGGTGGCGTGCAGGGCGTGGTTATTGCTGGTTCCACCGGCGAAGCAGCGACGTTGACCG
ATGCTGAGTATGACGAGATGCTGTGCTCGGCTGTGGTCCGAGTTGGTGGGCGTGTGCCGGTGTTGGCGGGTACTGGTTTG
TCTGGGACTGCGAAAACGATTTCTCAAACTAAACGCGCGGCCGACAATGGTGCAGGCTATGCTTTGGTGGTGACCCCTCC
GTACATACGTCCCAACCAAGGTGGTCTGAAGGCGCATTATTTGGCTGTGGCTGAGCAGGGGGGATTGCCAGTCGTGCTGT
ACAATGTGCCTAGCCGCACCGGCTGTGATCTGTTGCCGGAGACTGTCGCTGATTTGGCGGGGCACCCTAATATTGTCGGC
ATTAAGGAGGCGTGCGCTAGTCGTGAGCGCGTCCAGGCGCTGCTTGCTTTGCGTCGTCCAGGCTTTGCTGTATTCAGTGG
TGATGACAGCAGTGCTGCGCGTTCGATGTTGGACGGTGCCGATGGTTTGGTTTCGGTTGCTTCCAACGTATTGCCGTCCG
CTTATCGTCATCTATGTGATCTTGCTCGGGCGGGTGAGCGTGGTGCTATCGATCTGTGGAATGCGCGTCTGTCTGATTTT
CACGCATTTTGTGGTCTCGACTCCAATCCGATTCCAATTAAGGCATTGTTACAGCGTATCGGCATTGGTTATGGATTGCG
TCTGCCACTGCTACCCTTGTCGGTATGCCATCATGACATTGCCGATCACTTGGCTGACCAAGTGGCGGCATTGGAAGCAC
TTTCTAGCCGTAAAATAGTTACGGCCTGA

Upstream 100 bases:

>100_bases
CTTGCCCCTGCTTTCTTGCCGCAAGTAACATGTTTGGGATTGTATCCATGGCTTGTACTTCAAAGCTGTTGTCCTCATTA
ATTTTAAGAGTATTACTGTC

Downstream 100 bases:

>100_bases
CACATCAGGAGATTTTTCGATGCGTTTTTCTGTTACTACTCTTCACGTGTATGCACTCGTGTTATTGGTCGTTGCTGCAT
TGAGTGGTTGTACTTTGTTG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEMLCSAVVRVGGRVPVLAGTGL
SGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVG
IKEACASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARAGERGAIDLWNARLSDF
HAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIVTA

Sequences:

>Translated_302_residues
MSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEMLCSAVVRVGGRVPVLAGTGL
SGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVG
IKEACASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARAGERGAIDLWNARLSDF
HAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIVTA
>Mature_301_residues
SLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEMLCSAVVRVGGRVPVLAGTGLS
GTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVGI
KEACASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARAGERGAIDLWNARLSDFH
AFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIVTA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=228, Percent_Identity=34.6491228070175, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1788823, Length=274, Percent_Identity=42.3357664233577, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87082415, Length=266, Percent_Identity=32.3308270676692, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786463, Length=228, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789620, Length=228, Percent_Identity=27.1929824561404, Blast_Score=95, Evalue=5e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31557; Mature: 31426

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEM
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCHHHHH
LCSAVVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHY
HHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEE
LAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVGIKEACASRERVQALLALRRP
EEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCC
GFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARAGERGAIDLWNARLSDF
CEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
HAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIV
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TA
CC
>Mature Secondary Structure 
SLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEM
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCHHHHH
LCSAVVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHY
HHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEE
LAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVGIKEACASRERVQALLALRRP
EEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCC
GFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARAGERGAIDLWNARLSDF
CEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
HAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIV
HHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]