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The map label for this gene is dnaX [H]

Identifier: 28198956

GI number: 28198956

Start: 1261440

End: 1263071

Strand: Reverse

Name: dnaX [H]

Synonym: PD1059

Alternate gene names: 28198956

Gene position: 1263071-1261440 (Counterclockwise)

Preceding gene: 28198959

Following gene: 28198955

Centisome position: 50.13

GC content: 51.59

Gene sequence:

>1632_bases
ATGTCCTATCTTGTTCTTGCTCGCAAATGGCGCCCCAAGCGGTTTGCTGAGCTGGTGGGTCAAGAGCATGTGGTCCGTGC
GCTGAGTAATGCATTGGAAAGTGGCCGTCTCCATCACGCCTTTCTGTTTACTGGCACCCGTGGTGTAGGCAAAACGACGA
TTGCGCGTATCTTCGCTAAATCATTGAACTGCGAGCAGGGTACCAGTGCCGATCCATGTGGCCGGTGTACAGCCTGCTTG
GATATTGATGTTGGTCGCTATATTGACTTGCTGGAGATCGACGCTGCCTCCAATACCGGTGTGGATGATGTGCGCGAGAT
GATAGAAAACGCGCAATACATGCCCTCCAGAGGCAAGTTTAAGGTCTACCTGATTGATGAAGTGCATATGCTCTCTAAAG
CAGCGTTTAACGCGCTGCTGAAGACGCTAGAGGAGCCACCGCCACACGTAAAATTTCTTCTGGCAACGACTGATCCTCAG
AAATTGCCGGTGACTGTGTTGTCTCGCTGCTTGCAGTTTAACTTGAAGCGCTTGGATGAGGAACAGATCCAGCGTCAAAT
CGCTAAGATCCTCACTGCTGAGCAAATCACAGCCGACGATACGGCGATCATAGAGCTTTCTAAGGCTGCTGACGGTTCAT
TACGCGATGGTTTGTCTTTGCTGGACCAGGCCATTGCTTATGCTGGAGGGACGTTACGCGAGGGCGCAGTACGTGACATG
CTCGGTACGGTTGATCGTACTCAGGTTGAGGTGATGTTGGCTGCATTAATCGCAGGTGACGGTGATCGACTATTGCGGGT
GATAGCAACCTTGGCTGAGTTTTCGCCGGACTGGGGCGGGGTGTTGGAGGCCCTGGCTGAAGCTTTGCACAGGATTCAGG
TACAGCAACTAGTGCCTTCGGTGGTGTTTGCAGGTGATGGATTAAATGTTGCCTTATTGGCCGAACAAACACAGCCGGAG
GTTGTGCAACTTTGGTACCAGATGGCAATCAATGGACGTCACGACTTACATTTGGCACCGAGTCCACGTGTAGGATTTGA
GATGGCAGTGCTGCGGATGCTCGCTTTCCGACCTGTTCCTGTGGTTGTACCGGGTATGGTTTCGACTGAGGGGCAGGGGC
AGAGTGTTAATGCCCCACTAATGGCGTCTGTTGGTAGGAATGCACATGGGGCTAATGGATATACGATGTCCCAATCCCGT
TCTGATCTCCAGAAAGTCCGAGTTGGTTCTTTGGATGGGAAGATCACTGATGTTGGGCAATGGCTTGCGTTGGTCGAGCG
CATTGAGTTAAGTGGTCCTTCTAAGCAATTGGCTGCTCATGCCGCTTTTGTCTCTCATGAGAACAACGTCCTTTCTTTAG
CCTTAGCCCCTGAGTTTGAATATCTACAATCGACACGTTCTGTGGCCGATTTGACCCAGGGGTTGACCCGGTTGCTGGGT
CAGGCCCCCGAAGTGAAGATTGAGGCCAGAAACATTCAAGTTGAAACTCTTCATGAGCGCACCTATCGTCAGAAGAGTGA
GCGCCAACAGTTGGCCGAAGAAGCCTTCATGAGCGATCATGTGGTACAGCATCTGATCTATCAGCAGGCTGCCAAAGTTG
TTACCGATTCCATACGCCCTTACGATGAGTAA

Upstream 100 bases:

>100_bases
TAGCGCCGCTTAGCATTCTTCACAAGTTTAATTACGCTATATATGGGGTCCCTGCATCTGAGCATGGCACAATGGCAAAC
CACATGAAGATGATCGCCTA

Downstream 100 bases:

>100_bases
TGAATGATGCGAGGCAATATTGCCCAATTGATGCAGCAAGCACAGAAGATGCAGGAGAATCTGCAGCGTGCCCAAGAAGA
ATTAGCCAAGTTGGAGGTCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MSYLVLARKWRPKRFAELVGQEHVVRALSNALESGRLHHAFLFTGTRGVGKTTIARIFAKSLNCEQGTSADPCGRCTACL
DIDVGRYIDLLEIDAASNTGVDDVREMIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPPHVKFLLATTDPQ
KLPVTVLSRCLQFNLKRLDEEQIQRQIAKILTAEQITADDTAIIELSKAADGSLRDGLSLLDQAIAYAGGTLREGAVRDM
LGTVDRTQVEVMLAALIAGDGDRLLRVIATLAEFSPDWGGVLEALAEALHRIQVQQLVPSVVFAGDGLNVALLAEQTQPE
VVQLWYQMAINGRHDLHLAPSPRVGFEMAVLRMLAFRPVPVVVPGMVSTEGQGQSVNAPLMASVGRNAHGANGYTMSQSR
SDLQKVRVGSLDGKITDVGQWLALVERIELSGPSKQLAAHAAFVSHENNVLSLALAPEFEYLQSTRSVADLTQGLTRLLG
QAPEVKIEARNIQVETLHERTYRQKSERQQLAEEAFMSDHVVQHLIYQQAAKVVTDSIRPYDE

Sequences:

>Translated_543_residues
MSYLVLARKWRPKRFAELVGQEHVVRALSNALESGRLHHAFLFTGTRGVGKTTIARIFAKSLNCEQGTSADPCGRCTACL
DIDVGRYIDLLEIDAASNTGVDDVREMIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPPHVKFLLATTDPQ
KLPVTVLSRCLQFNLKRLDEEQIQRQIAKILTAEQITADDTAIIELSKAADGSLRDGLSLLDQAIAYAGGTLREGAVRDM
LGTVDRTQVEVMLAALIAGDGDRLLRVIATLAEFSPDWGGVLEALAEALHRIQVQQLVPSVVFAGDGLNVALLAEQTQPE
VVQLWYQMAINGRHDLHLAPSPRVGFEMAVLRMLAFRPVPVVVPGMVSTEGQGQSVNAPLMASVGRNAHGANGYTMSQSR
SDLQKVRVGSLDGKITDVGQWLALVERIELSGPSKQLAAHAAFVSHENNVLSLALAPEFEYLQSTRSVADLTQGLTRLLG
QAPEVKIEARNIQVETLHERTYRQKSERQQLAEEAFMSDHVVQHLIYQQAAKVVTDSIRPYDE
>Mature_542_residues
SYLVLARKWRPKRFAELVGQEHVVRALSNALESGRLHHAFLFTGTRGVGKTTIARIFAKSLNCEQGTSADPCGRCTACLD
IDVGRYIDLLEIDAASNTGVDDVREMIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPPHVKFLLATTDPQK
LPVTVLSRCLQFNLKRLDEEQIQRQIAKILTAEQITADDTAIIELSKAADGSLRDGLSLLDQAIAYAGGTLREGAVRDML
GTVDRTQVEVMLAALIAGDGDRLLRVIATLAEFSPDWGGVLEALAEALHRIQVQQLVPSVVFAGDGLNVALLAEQTQPEV
VQLWYQMAINGRHDLHLAPSPRVGFEMAVLRMLAFRPVPVVVPGMVSTEGQGQSVNAPLMASVGRNAHGANGYTMSQSRS
DLQKVRVGSLDGKITDVGQWLALVERIELSGPSKQLAAHAAFVSHENNVLSLALAPEFEYLQSTRSVADLTQGLTRLLGQ
APEVKIEARNIQVETLHERTYRQKSERQQLAEEAFMSDHVVQHLIYQQAAKVVTDSIRPYDE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=298, Percent_Identity=26.8456375838926, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI31881687, Length=298, Percent_Identity=26.8456375838926, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI31563534, Length=224, Percent_Identity=24.1071428571429, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786676, Length=368, Percent_Identity=54.8913043478261, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1787341, Length=241, Percent_Identity=30.2904564315353, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787119, Length=195, Percent_Identity=29.2307692307692, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=282, Percent_Identity=24.468085106383, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=223, Percent_Identity=26.0089686098655, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=317, Percent_Identity=25.8675078864353, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=224, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322528, Length=296, Percent_Identity=25.3378378378378, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=226, Percent_Identity=25.2212389380531, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI18859927, Length=292, Percent_Identity=24.6575342465753, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647857, Length=300, Percent_Identity=24, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921076, Length=258, Percent_Identity=27.5193798449612, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 59665; Mature: 59534

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVLARKWRPKRFAELVGQEHVVRALSNALESGRLHHAFLFTGTRGVGKTTIARIFAK
CCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHH
SLNCEQGTSADPCGRCTACLDIDVGRYIDLLEIDAASNTGVDDVREMIENAQYMPSRGKF
HCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSKAAFNALLKTLEEPPPHVKFLLATTDPQKLPVTVLSRCLQFNLKRLDE
EEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIQRQIAKILTAEQITADDTAIIELSKAADGSLRDGLSLLDQAIAYAGGTLREGAVRDM
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LGTVDRTQVEVMLAALIAGDGDRLLRVIATLAEFSPDWGGVLEALAEALHRIQVQQLVPS
HHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVFAGDGLNVALLAEQTQPEVVQLWYQMAINGRHDLHLAPSPRVGFEMAVLRMLAFRPVP
HEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCCC
VVVPGMVSTEGQGQSVNAPLMASVGRNAHGANGYTMSQSRSDLQKVRVGSLDGKITDVGQ
EEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
WLALVERIELSGPSKQLAAHAAFVSHENNVLSLALAPEFEYLQSTRSVADLTQGLTRLLG
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
QAPEVKIEARNIQVETLHERTYRQKSERQQLAEEAFMSDHVVQHLIYQQAAKVVTDSIRP
CCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YDE
CCC
>Mature Secondary Structure 
SYLVLARKWRPKRFAELVGQEHVVRALSNALESGRLHHAFLFTGTRGVGKTTIARIFAK
CEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHH
SLNCEQGTSADPCGRCTACLDIDVGRYIDLLEIDAASNTGVDDVREMIENAQYMPSRGKF
HCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSKAAFNALLKTLEEPPPHVKFLLATTDPQKLPVTVLSRCLQFNLKRLDE
EEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIQRQIAKILTAEQITADDTAIIELSKAADGSLRDGLSLLDQAIAYAGGTLREGAVRDM
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LGTVDRTQVEVMLAALIAGDGDRLLRVIATLAEFSPDWGGVLEALAEALHRIQVQQLVPS
HHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVFAGDGLNVALLAEQTQPEVVQLWYQMAINGRHDLHLAPSPRVGFEMAVLRMLAFRPVP
HEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCCC
VVVPGMVSTEGQGQSVNAPLMASVGRNAHGANGYTMSQSRSDLQKVRVGSLDGKITDVGQ
EEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
WLALVERIELSGPSKQLAAHAAFVSHENNVLSLALAPEFEYLQSTRSVADLTQGLTRLLG
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
QAPEVKIEARNIQVETLHERTYRQKSERQQLAEEAFMSDHVVQHLIYQQAAKVVTDSIRP
CCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YDE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]