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The map label for this gene is ispA [H]

Identifier: 62185577

GI number: 62185577

Start: 1141316

End: 1142197

Strand: Direct

Name: ispA [H]

Synonym: CAB979

Alternate gene names: 62185577

Gene position: 1141316-1142197 (Clockwise)

Preceding gene: 62185576

Following gene: NA

Centisome position: 99.73

GC content: 39.34

Gene sequence:

>882_bases
ATGGTCGTTATGGATATTTTCGAAGCTTACCGCGTAATGATAGAAACTGGGATAGAAAATTCTTTAGATGAGTTTGGTCC
TAAAGGATTCTCTATACGAGCCCCTGTAGAATATGCGTTAACCAGCGGTGGTAAACGCATTCGCCCTATGTTAGTCTGTA
TGATGGCTAAAGGTCTCGGTATGGGCAGAGATGTCTTAGACTCTGCATTAGCTATAGAATTCATACACACGTCCACATTA
ATCGCTGATGATCTTCCTTGTATGGATGACGATGATGAGCGTCGTGGGCGCCCTACAGTACATAAAGCTTTCGATGAAGC
TTCTGCTTTATTAGCATCTTATGCTTTGATTCCTGCTGCCTATTCCCGCATTCGTTTAAATGCAAAAAAACTCAAATCTT
TAGGTGTGGATTCTAAGGAAGTAGATTGTGCTTATGATATAATTTCTGATATCACCGATAAAAATTTTGGCGTCCACGGT
GTTTTAGGAGGACAATATGAAGATATGTTCTTCACTAATCATGGTCCTGAACATGTTCAATCCATTATTAATAAAAAAAC
TGGAGCCCTTTTTGAAATTGCTTGTGTCTCCGGCTGGTTGTTTGGAGGAGGAACTCCCCAATGTGTTCCACAAGTACTGG
AATTTTCTCAAACTTTCGGTCTGCTTTTTCAAATAAAAGATGATATTTTGGATATACATCAAGATGATCAAGATGTCGGG
CTAAACTACGCACTATTATTTGGTCTAGATGCGGCAAAAGACCTCTTAAATAGCTCCAAAGACAAGTGCCTTACCTTAAT
ACACCATCTTAAACACTATAGGCTAAAAGACACTTCAGAATTAGAAAGGCTCGTAGAATATATGGGGACTCGAGACTACT
AA

Upstream 100 bases:

>100_bases
GTTTCTGTAGGTTGCAATACTGTGATTAATCCTGGGCAGTGCATTCCAGCCCATACAAAAATTTATCCCGGAAAAGTTAT
CTAGGTTTAGGGCAAATTCT

Downstream 100 bases:

>100_bases
AAAGTTGAATATGAAAAAATCTGGGTGAGAGGATTTGAACCTCCGCCCCCTTGCACCCCATGCAAGTGCGCTACCAGGCT
GCGCTACACCCAGGAAATAC

Product: geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MVVMDIFEAYRVMIETGIENSLDEFGPKGFSIRAPVEYALTSGGKRIRPMLVCMMAKGLGMGRDVLDSALAIEFIHTSTL
IADDLPCMDDDDERRGRPTVHKAFDEASALLASYALIPAAYSRIRLNAKKLKSLGVDSKEVDCAYDIISDITDKNFGVHG
VLGGQYEDMFFTNHGPEHVQSIINKKTGALFEIACVSGWLFGGGTPQCVPQVLEFSQTFGLLFQIKDDILDIHQDDQDVG
LNYALLFGLDAAKDLLNSSKDKCLTLIHHLKHYRLKDTSELERLVEYMGTRDY

Sequences:

>Translated_293_residues
MVVMDIFEAYRVMIETGIENSLDEFGPKGFSIRAPVEYALTSGGKRIRPMLVCMMAKGLGMGRDVLDSALAIEFIHTSTL
IADDLPCMDDDDERRGRPTVHKAFDEASALLASYALIPAAYSRIRLNAKKLKSLGVDSKEVDCAYDIISDITDKNFGVHG
VLGGQYEDMFFTNHGPEHVQSIINKKTGALFEIACVSGWLFGGGTPQCVPQVLEFSQTFGLLFQIKDDILDIHQDDQDVG
LNYALLFGLDAAKDLLNSSKDKCLTLIHHLKHYRLKDTSELERLVEYMGTRDY
>Mature_293_residues
MVVMDIFEAYRVMIETGIENSLDEFGPKGFSIRAPVEYALTSGGKRIRPMLVCMMAKGLGMGRDVLDSALAIEFIHTSTL
IADDLPCMDDDDERRGRPTVHKAFDEASALLASYALIPAAYSRIRLNAKKLKSLGVDSKEVDCAYDIISDITDKNFGVHG
VLGGQYEDMFFTNHGPEHVQSIINKKTGALFEIACVSGWLFGGGTPQCVPQVLEFSQTFGLLFQIKDDILDIHQDDQDVG
LNYALLFGLDAAKDLLNSSKDKCLTLIHHLKHYRLKDTSELERLVEYMGTRDY

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=203, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786623, Length=274, Percent_Identity=36.1313868613139, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1789578, Length=239, Percent_Identity=30.1255230125523, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32597; Mature: 32597

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVMDIFEAYRVMIETGIENSLDEFGPKGFSIRAPVEYALTSGGKRIRPMLVCMMAKGLG
CCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHCCC
MGRDVLDSALAIEFIHTSTLIADDLPCMDDDDERRGRPTVHKAFDEASALLASYALIPAA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YSRIRLNAKKLKSLGVDSKEVDCAYDIISDITDKNFGVHGVLGGQYEDMFFTNHGPEHVQ
HHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCCHHHHH
SIINKKTGALFEIACVSGWLFGGGTPQCVPQVLEFSQTFGLLFQIKDDILDIHQDDQDVG
HHHHHCCCCEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LNYALLFGLDAAKDLLNSSKDKCLTLIHHLKHYRLKDTSELERLVEYMGTRDY
CCCCEEECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVVMDIFEAYRVMIETGIENSLDEFGPKGFSIRAPVEYALTSGGKRIRPMLVCMMAKGLG
CCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHCCC
MGRDVLDSALAIEFIHTSTLIADDLPCMDDDDERRGRPTVHKAFDEASALLASYALIPAA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YSRIRLNAKKLKSLGVDSKEVDCAYDIISDITDKNFGVHGVLGGQYEDMFFTNHGPEHVQ
HHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCCHHHHH
SIINKKTGALFEIACVSGWLFGGGTPQCVPQVLEFSQTFGLLFQIKDDILDIHQDDQDVG
HHHHHCCCCEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LNYALLFGLDAAKDLLNSSKDKCLTLIHHLKHYRLKDTSELERLVEYMGTRDY
CCCCEEECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]