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The map label for this gene is serS [H]

Identifier: 62185467

GI number: 62185467

Start: 1008845

End: 1010119

Strand: Direct

Name: serS [H]

Synonym: CAB865

Alternate gene names: 62185467

Gene position: 1008845-1010119 (Clockwise)

Preceding gene: 62185463

Following gene: 62185468

Centisome position: 88.16

GC content: 41.02

Gene sequence:

>1275_bases
ATGTTGGATATAAAATTAATACGCAAGGCACCTGAAGAATGTGAAACCCGTCTTCGTAAGAAAGATCCCCTTATTTCTCT
TCAGCCTATTCTTGATTTAGATAAAGAAATCCGTCACCTCAAGACAGAAACAGAAGCATTACAATCTCAAAGAAAACTTT
TGTCAAATCAGATCCATAAAGCGAAAGCTCAAGGAGAGGATGTGTCCTCGATGATGGATAATGTGGAGAGAATTTCTCAA
GACTTAGCCAAACTTGAACCTTTACTTGAGCAAAAGGAATCGACTTTACAAGACATGCTCGTACGTCTTCCTAACTATCC
TGACGAAGATGTCCCTGTATGCCCCGATAAAACGGGGAACCAGGTAATTAAACAAGTAGGTGCCTTACCTACATTTTCTT
TTACTCCTAAGCACCACGTAGAGCTCAACCAAAAATTACAAATTTTAGATTTTAAACTTCCTGCGAAAACTTCGGGTTCA
GGTTGGCCTGCATACAAAAACCAAGGTGTCTGTTTAGAATGGGCCTTATTAACCTATTTATTAAATAAGCAAAGAGAACA
CGGGTTTCAGTTATGGTTACCTCCTCTTCTCGTAAAACATGAAATCCTTTTTGGCTCAGGACAAATTCCTAAATTCGACG
GTCAGTATTACCGTGTAGAAGATGGAGAGCAATCTCTATATCTTATTCCTACGGCTGAGGTTGTTCTGAATGGCTTCCAT
TCTCAAGAAATTTTTAGTGAGAAGGACCTCCCTATATACTATGCGGCATTTACACCATGCTTTCGTAGAGAGGCGGGGGC
TGCAGGAGCTCACGAACGAGGACTCGTTCGTGTACACCAATTCCACAAAGTGGAGATGTTTGCCTTTACTACCCCAGATC
AAGCAGATCAGGCGTACGAAAAAATGCTCGCTGTGGTTGAAGATATTCTTACAGAATTACAACTCCCCTACCGGCTATCT
TTACTCTCCACAGGAGACATGTCTTTCACAGCATCAAAAACCATAGATGCTGAGGTTTGGCTACCTGGGCAACAATCTTA
CTATGAAGTTTCTTCTATTTCACAATGTACGGATTTCCAATCTCGTCGTTCGGAAACGCGTTATAAAGATAACCGCGGAA
AAATGCACTTTGTCCATACTCTCAATGGCTCCGGTTTAGCGACACCGCGTTTATTCGTAGCTATTTTAGAAAATAACCAG
CAAGAAGACGGTTCTGTGATTATTCCTGAAGTTTTACGCCCCTACTTAGAGAATCAAGAAGTATTATTACCATAG

Upstream 100 bases:

>100_bases
CCTAATTCTATAGCTCTTCGCATAAAAAATAGTTGTTGCTCAGAAAAATCTTCCATATACTTTATCTTTGTGAGAAAAAG
GTAATTCAAGAGACATAAGG

Downstream 100 bases:

>100_bases
GAGTAGCCTCTGTATGGTAAACATGAAAAAACCTAAGGCAATGTAAACCGTATACTGGATGGATAAAGTCAATGAATACT
GATTATGCTCACTTCAAAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDIKLIRKAPEECETRLRKKDPLISLQPILDLDKEIRHLKTETEALQSQRKLLSNQIHKAKAQGEDVSSMMDNVERISQ
DLAKLEPLLEQKESTLQDMLVRLPNYPDEDVPVCPDKTGNQVIKQVGALPTFSFTPKHHVELNQKLQILDFKLPAKTSGS
GWPAYKNQGVCLEWALLTYLLNKQREHGFQLWLPPLLVKHEILFGSGQIPKFDGQYYRVEDGEQSLYLIPTAEVVLNGFH
SQEIFSEKDLPIYYAAFTPCFRREAGAAGAHERGLVRVHQFHKVEMFAFTTPDQADQAYEKMLAVVEDILTELQLPYRLS
LLSTGDMSFTASKTIDAEVWLPGQQSYYEVSSISQCTDFQSRRSETRYKDNRGKMHFVHTLNGSGLATPRLFVAILENNQ
QEDGSVIIPEVLRPYLENQEVLLP

Sequences:

>Translated_424_residues
MLDIKLIRKAPEECETRLRKKDPLISLQPILDLDKEIRHLKTETEALQSQRKLLSNQIHKAKAQGEDVSSMMDNVERISQ
DLAKLEPLLEQKESTLQDMLVRLPNYPDEDVPVCPDKTGNQVIKQVGALPTFSFTPKHHVELNQKLQILDFKLPAKTSGS
GWPAYKNQGVCLEWALLTYLLNKQREHGFQLWLPPLLVKHEILFGSGQIPKFDGQYYRVEDGEQSLYLIPTAEVVLNGFH
SQEIFSEKDLPIYYAAFTPCFRREAGAAGAHERGLVRVHQFHKVEMFAFTTPDQADQAYEKMLAVVEDILTELQLPYRLS
LLSTGDMSFTASKTIDAEVWLPGQQSYYEVSSISQCTDFQSRRSETRYKDNRGKMHFVHTLNGSGLATPRLFVAILENNQ
QEDGSVIIPEVLRPYLENQEVLLP
>Mature_424_residues
MLDIKLIRKAPEECETRLRKKDPLISLQPILDLDKEIRHLKTETEALQSQRKLLSNQIHKAKAQGEDVSSMMDNVERISQ
DLAKLEPLLEQKESTLQDMLVRLPNYPDEDVPVCPDKTGNQVIKQVGALPTFSFTPKHHVELNQKLQILDFKLPAKTSGS
GWPAYKNQGVCLEWALLTYLLNKQREHGFQLWLPPLLVKHEILFGSGQIPKFDGQYYRVEDGEQSLYLIPTAEVVLNGFH
SQEIFSEKDLPIYYAAFTPCFRREAGAAGAHERGLVRVHQFHKVEMFAFTTPDQADQAYEKMLAVVEDILTELQLPYRLS
LLSTGDMSFTASKTIDAEVWLPGQQSYYEVSSISQCTDFQSRRSETRYKDNRGKMHFVHTLNGSGLATPRLFVAILENNQ
QEDGSVIIPEVLRPYLENQEVLLP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=438, Percent_Identity=34.4748858447489, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI225579074, Length=442, Percent_Identity=33.710407239819, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI16306548, Length=320, Percent_Identity=31.875, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=39.3939393939394, Blast_Score=303, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17539260, Length=464, Percent_Identity=29.5258620689655, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=267, Percent_Identity=33.7078651685393, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=374, Percent_Identity=33.4224598930481, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=410, Percent_Identity=31.4634146341463, Blast_Score=203, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24581334, Length=416, Percent_Identity=30.2884615384615, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17737985, Length=355, Percent_Identity=33.5211267605634, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48410; Mature: 48410

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKLIRKAPEECETRLRKKDPLISLQPILDLDKEIRHLKTETEALQSQRKLLSNQIHK
CCCHHHHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAQGEDVSSMMDNVERISQDLAKLEPLLEQKESTLQDMLVRLPNYPDEDVPVCPDKTGN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
QVIKQVGALPTFSFTPKHHVELNQKLQILDFKLPAKTSGSGWPAYKNQGVCLEWALLTYL
HHHHHHCCCCCCCCCCCHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
LNKQREHGFQLWLPPLLVKHEILFGSGQIPKFDGQYYRVEDGEQSLYLIPTAEVVLNGFH
HHHHHHCCCEEECCHHHHHHHHEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHCCCH
SQEIFSEKDLPIYYAAFTPCFRREAGAAGAHERGLVRVHQFHKVEMFAFTTPDQADQAYE
HHHHHCCCCCCEEEEHHCHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEECCCCHHHHHHH
KMLAVVEDILTELQLPYRLSLLSTGDMSFTASKTIDAEVWLPGQQSYYEVSSISQCTDFQ
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHH
SRRSETRYKDNRGKMHFVHTLNGSGLATPRLFVAILENNQQEDGSVIIPEVLRPYLENQE
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHEEEEECCCCCCCCCEECHHHHHHHHCCCC
VLLP
CCCC
>Mature Secondary Structure
MLDIKLIRKAPEECETRLRKKDPLISLQPILDLDKEIRHLKTETEALQSQRKLLSNQIHK
CCCHHHHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAQGEDVSSMMDNVERISQDLAKLEPLLEQKESTLQDMLVRLPNYPDEDVPVCPDKTGN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
QVIKQVGALPTFSFTPKHHVELNQKLQILDFKLPAKTSGSGWPAYKNQGVCLEWALLTYL
HHHHHHCCCCCCCCCCCHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
LNKQREHGFQLWLPPLLVKHEILFGSGQIPKFDGQYYRVEDGEQSLYLIPTAEVVLNGFH
HHHHHHCCCEEECCHHHHHHHHEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHCCCH
SQEIFSEKDLPIYYAAFTPCFRREAGAAGAHERGLVRVHQFHKVEMFAFTTPDQADQAYE
HHHHHCCCCCCEEEEHHCHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEECCCCHHHHHHH
KMLAVVEDILTELQLPYRLSLLSTGDMSFTASKTIDAEVWLPGQQSYYEVSSISQCTDFQ
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHH
SRRSETRYKDNRGKMHFVHTLNGSGLATPRLFVAILENNQQEDGSVIIPEVLRPYLENQE
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHEEEEECCCCCCCCCEECHHHHHHHHCCCC
VLLP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]