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The map label for this gene is phhA

Identifier: 62185294

GI number: 62185294

Start: 791950

End: 792783

Strand: Direct

Name: phhA

Synonym: CAB681

Alternate gene names: NA

Gene position: 791950-792783 (Clockwise)

Preceding gene: 62185286

Following gene: 62185295

Centisome position: 69.2

GC content: 37.89

Gene sequence:

>834_bases
ATGACTCATCACATCGCTGCGCTACTTTCGCATTCTGAAAGTTATGCAGATGCACTATTAAATTCTCGACTTGCTTTATG
GGAGGCTTATTGTCCCCAAGTTTTTTTTGAGTACTTAGATGCTCTACATTTAACTGCAGGATCAGTGATAGATATTGATC
ACATTCACCACACTATCCTGTCACAAACAGGATTCACATTATCCCCAGCAAAAGATTATCTCTCACCACACGACTATTTA
TTTGAGTTAAGTCAGCAACGGTTTCCTATAGCTAGACATATACGCAAAATGGAGAATGACAGTTTTTCGCCTCTTCCTGA
TCTCATTCACGATTTATTTTGCCATGTTCCATGGTTATTGCATCAAGAATTTGTAAAATTTTTCTCTTCTATGGGGAAGC
TCTTTATAAAAGCTGTAGAACGGGCAAAAGCAATCTACTCTATAGAAGACCAGCCTCGAATACTTAACAGCAATGTGCTA
GCAATCTCGCGGTGTTTCTGGTTTACAGTAGAAAATGGTCTTATTGAAACACAGGGAAAGAGAAAAGCCTACGGGGCTGC
GATATTAAGCTCCACAGATCAGTTATCCTATACCTTTAATAACAACGTATTCGTTTCTCCATTTAAGACCGAACACATTA
TACAACGCCCCTGCAATCCACAATCCTTACAGACCACTTTCTTTATCATTCGTGATTTTAGCGAATTAAATGACGTTGCA
GAAAAAATGCACGGATTTCTAGAACAAGGACGTCTTGATTTTATTGTCTGTGGTCCACATGACGTATACTATCAAGATAT
TATCTATTTTTTAAACGAACATGTCTTTTCATAA

Upstream 100 bases:

>100_bases
TTGATTCTTTCAACACGAATTATTCTTTATAATCTGTAATAGTTTATACAAGTAGAAAGCTTTTTTAAATAGGTACTAAA
CTATAAACTTCTATTTATTC

Downstream 100 bases:

>100_bases
AGATAGGGTACTTTTTAACCTATCACTCACATTTTCATTGATTTTGATCTTATCAAATCTCGTCGCAGCTTCTAGGCTTG
TGATTACCTCCTACTTCACG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MTHHIAALLSHSESYADALLNSRLALWEAYCPQVFFEYLDALHLTAGSVIDIDHIHHTILSQTGFTLSPAKDYLSPHDYL
FELSQQRFPIARHIRKMENDSFSPLPDLIHDLFCHVPWLLHQEFVKFFSSMGKLFIKAVERAKAIYSIEDQPRILNSNVL
AISRCFWFTVENGLIETQGKRKAYGAAILSSTDQLSYTFNNNVFVSPFKTEHIIQRPCNPQSLQTTFFIIRDFSELNDVA
EKMHGFLEQGRLDFIVCGPHDVYYQDIIYFLNEHVFS

Sequences:

>Translated_277_residues
MTHHIAALLSHSESYADALLNSRLALWEAYCPQVFFEYLDALHLTAGSVIDIDHIHHTILSQTGFTLSPAKDYLSPHDYL
FELSQQRFPIARHIRKMENDSFSPLPDLIHDLFCHVPWLLHQEFVKFFSSMGKLFIKAVERAKAIYSIEDQPRILNSNVL
AISRCFWFTVENGLIETQGKRKAYGAAILSSTDQLSYTFNNNVFVSPFKTEHIIQRPCNPQSLQTTFFIIRDFSELNDVA
EKMHGFLEQGRLDFIVCGPHDVYYQDIIYFLNEHVFS
>Mature_276_residues
THHIAALLSHSESYADALLNSRLALWEAYCPQVFFEYLDALHLTAGSVIDIDHIHHTILSQTGFTLSPAKDYLSPHDYLF
ELSQQRFPIARHIRKMENDSFSPLPDLIHDLFCHVPWLLHQEFVKFFSSMGKLFIKAVERAKAIYSIEDQPRILNSNVLA
ISRCFWFTVENGLIETQGKRKAYGAAILSSTDQLSYTFNNNVFVSPFKTEHIIQRPCNPQSLQTTFFIIRDFSELNDVAE
KMHGFLEQGRLDFIVCGPHDVYYQDIIYFLNEHVFS

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4759248, Length=227, Percent_Identity=27.3127753303965, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI31795563, Length=199, Percent_Identity=27.6381909547739, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI88900503, Length=191, Percent_Identity=28.2722513089005, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI88900501, Length=191, Percent_Identity=28.2722513089005, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI88900505, Length=191, Percent_Identity=28.2722513089005, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI4557819, Length=199, Percent_Identity=25.6281407035176, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17531391, Length=146, Percent_Identity=29.4520547945205, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532103, Length=225, Percent_Identity=21.7777777777778, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115533973, Length=225, Percent_Identity=21.7777777777778, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980736, Length=158, Percent_Identity=28.4810126582279, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136774, Length=176, Percent_Identity=27.8409090909091, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136776, Length=176, Percent_Identity=27.8409090909091, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24654994, Length=196, Percent_Identity=28.0612244897959, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472054, Length=178, Percent_Identity=28.0898876404494, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24660393, Length=178, Percent_Identity=28.0898876404494, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: 1.14.16.-

Molecular weight: Translated: 32038; Mature: 31907

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHHIAALLSHSESYADALLNSRLALWEAYCPQVFFEYLDALHLTAGSVIDIDHIHHTIL
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
SQTGFTLSPAKDYLSPHDYLFELSQQRFPIARHIRKMENDSFSPLPDLIHDLFCHVPWLL
HHCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
HQEFVKFFSSMGKLFIKAVERAKAIYSIEDQPRILNSNVLAISRCFWFTVENGLIETQGK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEECCCEEECCCC
RKAYGAAILSSTDQLSYTFNNNVFVSPFKTEHIIQRPCNPQSLQTTFFIIRDFSELNDVA
HHHHHHHHHCCCCCEEEEECCCEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EKMHGFLEQGRLDFIVCGPHDVYYQDIIYFLNEHVFS
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THHIAALLSHSESYADALLNSRLALWEAYCPQVFFEYLDALHLTAGSVIDIDHIHHTIL
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
SQTGFTLSPAKDYLSPHDYLFELSQQRFPIARHIRKMENDSFSPLPDLIHDLFCHVPWLL
HHCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
HQEFVKFFSSMGKLFIKAVERAKAIYSIEDQPRILNSNVLAISRCFWFTVENGLIETQGK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEECCCEEECCCC
RKAYGAAILSSTDQLSYTFNNNVFVSPFKTEHIIQRPCNPQSLQTTFFIIRDFSELNDVA
HHHHHHHHHCCCCCEEEEECCCEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EKMHGFLEQGRLDFIVCGPHDVYYQDIIYFLNEHVFS
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]