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The map label for this gene is groEL [H]

Identifier: 62185227

GI number: 62185227

Start: 705639

End: 707273

Strand: Direct

Name: groEL [H]

Synonym: CAB615

Alternate gene names: 62185227

Gene position: 705639-707273 (Clockwise)

Preceding gene: 62185226

Following gene: 62185228

Centisome position: 61.66

GC content: 41.35

Gene sequence:

>1635_bases
ATGGCAGCAAAAAATATTAAATATAACGAAGACGCCAGAAAAAAAATCCACAAGGGAGTGAAAACTCTTGCAGAAGCTGT
AAAAGTAACCTTAGGTCCTAAAGGACGTCATGTGGTTATCGATAAAAGCTTCGGTTCTCCTCAAGTTACAAAAGACGGTG
TAACTGTCGCTAAAGAAATTGAGCTCGAAGACAAACACGAGAACATGGGAGCTCAAATGGTGAAAGAAGTTGCTAGCAAA
ACTGCAGATAAAGCTGGTGACGGAACTACCACAGCTACTGTTCTTGCTGAAGCTATCTACAGTGAAGGATTGAGAAATGT
GACTGCAGGCGCCAATCCTATGGACCTCAAAAGAGGTATTGATAAAGCTGTCAAAGTCGTTGTAGATCAAATCAAAAAAA
TTAGTAAACCTGTACAGCATCACAAAGAAATCGCTCAAGTAGCGACGATTTCTGCTAACAATGATGCTGAAATTGGTAAT
CTCATCGCCGAAGCCATGGAAAAAGTGGGGAAAAACGGCTCTATTACTGTTGAGGAAGCTAAAGGTTTCGAAACTGTTCT
CGATGTTGTTGAAGGTATGAATTTCAACCGCGGGTATCTTTCTAGCTACTTCACTACAAATCCTGAAACACAAGAATGTG
TGTTAGAAGAAGCTCTTGTGCTTATCTACGACAAAAAAATTTCCGGAATTAAAGATTTCCTTCCAGTTTTACAACAGGTA
GCAGAATCCGGACGTCCCCTATTAATTATTGCTGAAGATATCGAAGGCGAAGCTTTAGCAACTTTAGTCGTCAACAGACT
ACGTGCAGGATTCAGAGTGTGCGCAGTTAAAGCTCCTGGATTCGGTGATAGAAGAAAAGCTATGTTGGAAGACATCGCTA
TCTTAACCGGTGGCCAATTGATCAGCGAAGAGCTGGGTATGAAGCTGGAAAACACCACTTTATCCATGCTAGGAAAAGCT
AAGAAAGTCATCGTTTCTAAAGAAGATACCACAATTGTTGAAGGCCTCGGAAACAAAGAAGATATCGAAGCTCGATGCGA
AAATATCAAAAAACAAATCGAAGACAGCACCTCGGATTATGATAAAGAAAAACTCCAAGAACGGTTGGCAAAACTCTCCG
GAGGCATAGCTGTAATCCGTGTAGGAGCTGCTACAGAAATTGAAATGAAAGAGAAAAAAGATAGAGTAGATGACGCTCAA
CACGCAACTCTTGCTGCAGTTGAAGAAGGAATCTTACCAGGTGGTGGTACAGCTTTAGTACGCTGCATCCCTACTTTAGA
AGCTTTCATTCCAGTTCTTACAAATGAAGATGAGCAAATCGGAGCACGTATTGTTCTTAAAGCTCTATCCGCTCCTTTAA
AACAAATCGCAGCAAATGCTGGTAAAGAAGGTGCTATCATCTGCCAGCAAGTACTTGCTCGCTCTTCTAACGAAGGCTAC
GATGCTTTGCGCGATGCTTACACTGATATGATCGAAGCAGGAATTCTTGACCCAACTAAAGTAACACGTTGTGCTTTAGA
AAGTGCAGCTTCTGTAGCTGGACTTCTATTAACAACAGAAGCTTTAATTGCTGATATTCCTGAAGAAAAATCCTCTTCTG
TTCCAGCAATGCCAGGCGCAGGAATGGATTATTAA

Upstream 100 bases:

>100_bases
GAGGAGTACGTCATTGTTCAAGAAAGCGAAGTTATGGCAGTTCTCAAGTAAGACTGATAATTATTTATAGATTGCAAAAA
GTTAAGGAGCACAAAAAACA

Downstream 100 bases:

>100_bases
TCCACGATATAGAGAACTTTTTCTCTATTCTTACAAGGTCTCCCTTCATCTATCTCAAGAGGAAGGGAGACCTTTTTCAT
TTTGTAATATTTCTTTCTTC

Product: chaperonin GroEL

Products: NA

Alternate protein names: 57 kDa chlamydial hypersensitivity antigen; GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAAKNIKYNEDARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGN
LIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFTTNPETQECVLEEALVLIYDKKISGIKDFLPVLQQV
AESGRPLLIIAEDIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENTTLSMLGKA
KKVIVSKEDTTIVEGLGNKEDIEARCENIKKQIEDSTSDYDKEKLQERLAKLSGGIAVIRVGAATEIEMKEKKDRVDDAQ
HATLAAVEEGILPGGGTALVRCIPTLEAFIPVLTNEDEQIGARIVLKALSAPLKQIAANAGKEGAIICQQVLARSSNEGY
DALRDAYTDMIEAGILDPTKVTRCALESAASVAGLLLTTEALIADIPEEKSSSVPAMPGAGMDY

Sequences:

>Translated_544_residues
MAAKNIKYNEDARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGN
LIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFTTNPETQECVLEEALVLIYDKKISGIKDFLPVLQQV
AESGRPLLIIAEDIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENTTLSMLGKA
KKVIVSKEDTTIVEGLGNKEDIEARCENIKKQIEDSTSDYDKEKLQERLAKLSGGIAVIRVGAATEIEMKEKKDRVDDAQ
HATLAAVEEGILPGGGTALVRCIPTLEAFIPVLTNEDEQIGARIVLKALSAPLKQIAANAGKEGAIICQQVLARSSNEGY
DALRDAYTDMIEAGILDPTKVTRCALESAASVAGLLLTTEALIADIPEEKSSSVPAMPGAGMDY
>Mature_543_residues
AAKNIKYNEDARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKT
ADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGNL
IAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFTTNPETQECVLEEALVLIYDKKISGIKDFLPVLQQVA
ESGRPLLIIAEDIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENTTLSMLGKAK
KVIVSKEDTTIVEGLGNKEDIEARCENIKKQIEDSTSDYDKEKLQERLAKLSGGIAVIRVGAATEIEMKEKKDRVDDAQH
ATLAAVEEGILPGGGTALVRCIPTLEAFIPVLTNEDEQIGARIVLKALSAPLKQIAANAGKEGAIICQQVLARSSNEGYD
ALRDAYTDMIEAGILDPTKVTRCALESAASVAGLLLTTEALIADIPEEKSSSVPAMPGAGMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. This protein is implicated in the pathogenesis of chlamydial disease. Inflammation elicited by the 57 kDa antigen may damage tis

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=52.4621212121212, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=52.4621212121212, Blast_Score=548, Evalue=1e-156,
Organism=Escherichia coli, GI1790586, Length=534, Percent_Identity=61.2359550561798, Blast_Score=656, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=51.2241054613936, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI193210679, Length=213, Percent_Identity=52.5821596244132, Blast_Score=213, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=54.1825095057034, Blast_Score=548, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=52.2727272727273, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=52.2727272727273, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=529, Percent_Identity=49.9054820415879, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550132, Length=529, Percent_Identity=49.9054820415879, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550935, Length=529, Percent_Identity=49.9054820415879, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17864606, Length=545, Percent_Identity=44.4036697247706, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=37.0018975332068, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=37.0018975332068, Blast_Score=335, Evalue=4e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58262; Mature: 58130

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKNIKYNEDARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHC
ELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGI
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGNLIAEAMEKVGKNGSITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHH
KGFETVLDVVEGMNFNRGYLSSYFTTNPETQECVLEEALVLIYDKKISGIKDFLPVLQQV
CCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHH
AESGRPLLIIAEDIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEELGMKLENTTLSMLGKAKKVIVSKEDTTIVEGLGNKEDIEARCENIKKQIEDSTSDY
HHHHHCCEECHHHHHHHHHHHHHEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
DKEKLQERLAKLSGGIAVIRVGAATEIEMKEKKDRVDDAQHATLAAVEEGILPGGGTALV
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHH
RCIPTLEAFIPVLTNEDEQIGARIVLKALSAPLKQIAANAGKEGAIICQQVLARSSNEGY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCH
DALRDAYTDMIEAGILDPTKVTRCALESAASVAGLLLTTEALIADIPEEKSSSVPAMPGA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMDY
CCCC
>Mature Secondary Structure 
AAKNIKYNEDARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHC
ELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGI
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGNLIAEAMEKVGKNGSITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHH
KGFETVLDVVEGMNFNRGYLSSYFTTNPETQECVLEEALVLIYDKKISGIKDFLPVLQQV
CCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHH
AESGRPLLIIAEDIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEELGMKLENTTLSMLGKAKKVIVSKEDTTIVEGLGNKEDIEARCENIKKQIEDSTSDY
HHHHHCCEECHHHHHHHHHHHHHEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
DKEKLQERLAKLSGGIAVIRVGAATEIEMKEKKDRVDDAQHATLAAVEEGILPGGGTALV
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHH
RCIPTLEAFIPVLTNEDEQIGARIVLKALSAPLKQIAANAGKEGAIICQQVLARSSNEGY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCH
DALRDAYTDMIEAGILDPTKVTRCALESAASVAGLLLTTEALIADIPEEKSSSVPAMPGA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMDY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2571668; 12682364 [H]