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The map label for this gene is mmgC [H]

Identifier: 23501963

GI number: 23501963

Start: 1057379

End: 1058563

Strand: Reverse

Name: mmgC [H]

Synonym: BR1085

Alternate gene names: 23501963

Gene position: 1058563-1057379 (Counterclockwise)

Preceding gene: 23501965

Following gene: 23501962

Centisome position: 50.22

GC content: 56.96

Gene sequence:

>1185_bases
ATGTCACGTGCGGCTTTTGCCTGGGAAGATCCGTTTTTGCTGGAGGAGCAACTGACCGAAGACGAGCGCATGATCCGCGA
CTCGGCCAAGGCCTTTGCAAGCGACGTTCTTCTGCCTCGTGTCGAAAAAGCCTATCTGGAAGAAACCACCGACCCGGAAC
TGTTTCACCTCATGGGGCAGGCGGGGCTTCTGGGCGTAACGCTGCCGGAAGACTATGGCGCGGCCAATGCAAGCTATGTA
GCCTATGGGCTGGTGGCGCGCGAAGTGGAGCGCATTGATTCCGGATATCGTTCCATGATGAGCGTGCAATCGTCGCTCGT
CATGTATCCGATCTATGCCTATGGTTCGGATGAACAGCGCAAGAAATATCTTCCCGGCCTGGTTTCGGGTGAATTGATTG
GCTGTTTCGGCCTTACCGAACCCGATGCGGGTTCCGACCCGGCTGGCATGAAAACCCGCGCCGAAAAGATCGATGGCGGC
TATCGCCTCAGCGGCTCGAAGATGTGGATTTCCAATTCACCGATTGCCGATGTGTTCGTCGTCTGGGCAAAATCGGCTGC
GCATGACAACGCCATTCGCGGCTTCATTCTTGAAAAGGGCATGAAGGGACTTTCAGCACCGAAGATCGGGGGCAAGCTTT
CGCTGCGCGCTTCGATCACCGGCGAGATCGTGATGGATGGGGTTGAAGTTTCCGAAGACGCAATCCTGCCGAATGTTTCC
GGTCTCAAGGGCCCGTTTGGCTGTCTCAACCGCGCGCGCTATGGCATTTCGTGGGGTGTGCTCGGGGCTGCTGAAGATTG
CTGGTTCCGTGCGCGCCAATATGGTCTGGACCGCAAGCAATTCAACAAGCCGCTGGCTGGCACGCAGCTTTACCAGAAGA
AGCTTGCCGATATGCAGACGGAAATCGCGCTTGGGCTTCAGGCATCGCTTCGCGTTGGCCGCCTGTTCGATGAAGGCAAG
ATGGCGCCCGAAATGATTTCTATCGTCAAGCGCAACAATTGCGGCAAGGCTCTGGATATTGCCCGCCAGGCCCGTGATAT
GCATGGCGGCAACGGTATCCAGATTGAATATCACGTCATGCGCCACGCGCAGAATCTGGAAACCGTCAACACCTATGAGG
GCACGCACGACGTTCACGCGCTGATTCTCGGCCGTGCCCAGACCGGCATTCAGGCGTTCTTCTGA

Upstream 100 bases:

>100_bases
ATCTATTACTAAACGGAATAGATCGATGAGTAAACGTCGATTGCGTTCATCGTCGTGCCGCTCCATATTCCCTGCATATT
CAATCTGAGGAGAATACCTG

Downstream 100 bases:

>100_bases
TCGTCGGTTCCAAGCCTGCTTTTGGCCCGCTCGCAATTTGCGGGCGGGCTTTCTTATATTCATTTGGGATTGCTGAACAT
GCAGAACACACCGCTTGACG

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQAGLLGVTLPEDYGAANASYV
AYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQRKKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGG
YRLSGSKMWISNSPIADVFVVWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPNVS
GLKGPFGCLNRARYGISWGVLGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQTEIALGLQASLRVGRLFDEGK
MAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF

Sequences:

>Translated_394_residues
MSRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQAGLLGVTLPEDYGAANASYV
AYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQRKKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGG
YRLSGSKMWISNSPIADVFVVWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPNVS
GLKGPFGCLNRARYGISWGVLGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQTEIALGLQASLRVGRLFDEGK
MAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
>Mature_393_residues
SRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQAGLLGVTLPEDYGAANASYVA
YGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQRKKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGGY
RLSGSKMWISNSPIADVFVVWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPNVSG
LKGPFGCLNRARYGISWGVLGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQTEIALGLQASLRVGRLFDEGKM
APEMISIVKRNNCGKALDIARQARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=394, Percent_Identity=65.989847715736, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=64.7058823529412, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=30.8510638297872, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=30.6451612903226, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=31.5363881401617, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=31.7919075144509, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=29.7872340425532, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=29.7872340425532, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI76496475, Length=386, Percent_Identity=29.2746113989637, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4557235, Length=386, Percent_Identity=29.2746113989637, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI21361497, Length=395, Percent_Identity=28.3544303797468, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=27.2, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=28.3422459893048, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1786223, Length=339, Percent_Identity=24.188790560472, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081958, Length=377, Percent_Identity=23.6074270557029, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=64.4329896907217, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=33.8666666666667, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=30.958904109589, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=30.7277628032345, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=376, Percent_Identity=29.5212765957447, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71990804, Length=254, Percent_Identity=34.6456692913386, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=27.4406332453826, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=35.6521739130435, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71985184, Length=360, Percent_Identity=29.1666666666667, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=267, Percent_Identity=30.7116104868914, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=270, Percent_Identity=29.6296296296296, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=23.7333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17551932, Length=293, Percent_Identity=26.2798634812287, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=249, Percent_Identity=25.7028112449799, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=60.4591836734694, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=31.2328767123288, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=29.1891891891892, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=31.3984168865435, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.4666666666667, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=29.7587131367292, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281363737, Length=408, Percent_Identity=26.9607843137255, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43233; Mature: 43102

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQ
CCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AGLLGVTLPEDYGAANASYVAYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQR
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHH
KKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGGYRLSGSKMWISNSPIADVFV
HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCEEEECCCCHHHHHH
VWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPNVS
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCC
GLKGPFGCLNRARYGISWGVLGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQT
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
EIALGLQASLRVGRLFDEGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIEYHVM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEHHH
RHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
HHHHCCCCEECCCCCCCEEEEEEECHHCCHHHCC
>Mature Secondary Structure 
SRAAFAWEDPFLLEEQLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMGQ
CCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AGLLGVTLPEDYGAANASYVAYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQR
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHH
KKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGGYRLSGSKMWISNSPIADVFV
HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCEEEECCCCHHHHHH
VWAKSAAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAILPNVS
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCC
GLKGPFGCLNRARYGISWGVLGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQT
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
EIALGLQASLRVGRLFDEGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIEYHVM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEHHH
RHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
HHHHCCCCEECCCCCCCEEEEEEECHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]