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The map label for this gene is purC [H]

Identifier: 23501729

GI number: 23501729

Start: 818540

End: 819304

Strand: Reverse

Name: purC [H]

Synonym: BR0842

Alternate gene names: 23501729

Gene position: 819304-818540 (Counterclockwise)

Preceding gene: 23501732

Following gene: 23501728

Centisome position: 38.87

GC content: 56.21

Gene sequence:

>765_bases
ATGAACCGTCGCCGCCGTATTTACGAGGGCAAGGCCAAGATTCTTTATGAAGGCCCTGAGCCCGGTACGCTTGTCCAATT
CTTCAAAGATGACGCCACCGCTTTCAACGCGAAAAAGCACGAAGTCATCGACGGGAAAGGTGTGCTGAACAACCGTATTT
CCGAACACATCTTCACCCAGCTCAACCGCATTGGCATTCCAACGCACTTCATCCGCCGTCTCAACATGCGTGAGCAGCTG
ATCAAGGAAGTGGAAATCATTCCGCTTGAAGTGGTGGTGCGCAATGTTGCAGCCGGTTCGCTCGCAAAGCGCCTCGGCCT
TGAAGAAGGCACCATCCTGCCGCGCTCGATCATCGAATTCTACTATAAGGCCGATGCGCTCGACGACCCGATGGTCACAG
AAGAGCATATCACGGCTTTCGGCTGGGCTAGCCCGCAGGAAATCGACGACATCATGGCGCTCGCCATTCGCGTCAACGAC
TTCCTGACCGGCCTTTTCCTCGGCATTGGTATCCAGCTTGTCGATTTCAAGATGGAATGTGGCCGCCTGTGGGAAGGCGA
CATGATGCGCATCGTCGTTGCCGATGAAATCTCGCCGGATTCGGCTCGTCTTTGGGATATCACCACCAACGACAAGCTCG
ACAAGGACCGTTTCCGCCGCGATATGGGCGGTCTGGTCGAGGCCTATCAGGAAGTGGCACGCCGTCTCGGCATCATGAAC
GAGAACGACACGCCGCGCCCGTCCGGCCCAACGCTGGTGAAATAA

Upstream 100 bases:

>100_bases
CACAAAGCAGGATTGTTAAAAGCCGACAATTGCTATAGGTAGCCCGCGAGAATAACGGCTGAAAGCCGATCACCATAGAT
ATGGAAATCCGAGAAAAGCC

Downstream 100 bases:

>100_bases
CCATTCGCCCAGCCCGGAAGGGCATGATCCCGAAAAGTGGACACGGTTTTCGGGATCATGCCAGAACAAACCTTTCGGGC
TGTTTCATTCGTTCTAAAAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNRRRRIYEGKAKILYEGPEPGTLVQFFKDDATAFNAKKHEVIDGKGVLNNRISEHIFTQLNRIGIPTHFIRRLNMREQL
IKEVEIIPLEVVVRNVAAGSLAKRLGLEEGTILPRSIIEFYYKADALDDPMVTEEHITAFGWASPQEIDDIMALAIRVND
FLTGLFLGIGIQLVDFKMECGRLWEGDMMRIVVADEISPDSARLWDITTNDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENDTPRPSGPTLVK

Sequences:

>Translated_254_residues
MNRRRRIYEGKAKILYEGPEPGTLVQFFKDDATAFNAKKHEVIDGKGVLNNRISEHIFTQLNRIGIPTHFIRRLNMREQL
IKEVEIIPLEVVVRNVAAGSLAKRLGLEEGTILPRSIIEFYYKADALDDPMVTEEHITAFGWASPQEIDDIMALAIRVND
FLTGLFLGIGIQLVDFKMECGRLWEGDMMRIVVADEISPDSARLWDITTNDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENDTPRPSGPTLVK
>Mature_254_residues
MNRRRRIYEGKAKILYEGPEPGTLVQFFKDDATAFNAKKHEVIDGKGVLNNRISEHIFTQLNRIGIPTHFIRRLNMREQL
IKEVEIIPLEVVVRNVAAGSLAKRLGLEEGTILPRSIIEFYYKADALDDPMVTEEHITAFGWASPQEIDDIMALAIRVND
FLTGLFLGIGIQLVDFKMECGRLWEGDMMRIVVADEISPDSARLWDITTNDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENDTPRPSGPTLVK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=230, Percent_Identity=33.9130434782609, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI5453539, Length=230, Percent_Identity=33.9130434782609, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI119220559, Length=237, Percent_Identity=32.4894514767932, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=44.9579831932773, Blast_Score=211, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=233, Percent_Identity=32.618025751073, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18860083, Length=207, Percent_Identity=31.8840579710145, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=26.5700483091787, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28957; Mature: 28957

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLVQFFKDDATAFNAKKHEVIDGKGVLNNRISEHIFTQ
CCCCCCEECCCEEEEEECCCCCHHHHHHHCCHHHCCCCCCEECCCCCHHHHHHHHHHHHH
LNRIGIPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLAKRLGLEEGTILPRSIIEF
HHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKADALDDPMVTEEHITAFGWASPQEIDDIMALAIRVNDFLTGLFLGIGIQLVDFKMEC
HHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHC
GRLWEGDMMRIVVADEISPDSARLWDITTNDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
CCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ENDTPRPSGPTLVK
CCCCCCCCCCCCCC
>Mature Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLVQFFKDDATAFNAKKHEVIDGKGVLNNRISEHIFTQ
CCCCCCEECCCEEEEEECCCCCHHHHHHHCCHHHCCCCCCEECCCCCHHHHHHHHHHHHH
LNRIGIPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLAKRLGLEEGTILPRSIIEF
HHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKADALDDPMVTEEHITAFGWASPQEIDDIMALAIRVNDFLTGLFLGIGIQLVDFKMEC
HHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHC
GRLWEGDMMRIVVADEISPDSARLWDITTNDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
CCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ENDTPRPSGPTLVK
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA