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The map label for this gene is purL [H]

Identifier: 23501724

GI number: 23501724

Start: 813719

End: 815941

Strand: Reverse

Name: purL [H]

Synonym: BR0837

Alternate gene names: 23501724

Gene position: 815941-813719 (Counterclockwise)

Preceding gene: 23501725

Following gene: 23501723

Centisome position: 38.71

GC content: 59.11

Gene sequence:

>2223_bases
ATGACTATTTCCAATACGCGAGACATCACGCCGGAACTGATCGAAGCGCATGGTCTTAAGCCGGACGAGTATCAGCGCAT
TCTTGAGCTGATCGGGCGCGAGCCGACTTTTACCGAACTCGGCATTTTCTCCGCCATGTGGAATGAGCACTGCTCCTACA
AGTCCTCCAAGAAATGGCTACGCACACTTCCGACCAGCGGACCGCGCGTCATTCAAGGCCCCGGTGAAAATGCAGGCGTG
GTCGATATTGGCGATGGCGATTGCGTCGTCTTCAAGATGGAAAGCCACAATCACCCCTCCTATATCGAGCCTTATCAGGG
TGCCGCGACCGGCGTGGGCGGAATCTTGCGCGACGTGTTCACCATGGGCGCGCGCCCCGTTGCGGCAATGAATGCGCTGC
GCTTTGGCGAACCCGACCATCCAAAAACCCGCCACCTCGTCTCGGGCGTTGTTTCCGGCGTCGGCGGCTATGGCAATGCC
TTCGGCGTGCCGACTGTCGGTGGCGAGGTGAATTTCGACAAGCGCTATAACGGCAATATCCTCGTCAATGCCTTTGCTGC
CGGTCTTGCCCGGCATGATGGCATTTTCCTGTCGGAAGCCAAGGGCGTCGGCCTGCCGGTCGTCTATCTGGGTGCAAAGA
CTGGCCGCGATGGTGTTGGCGGTGCAACAATGGCATCGGCTGAATTCGACGAGTCGATCGAGGAAAAGCGCCCCACCGTT
CAGGTGGGCGATCCTTTCACCGAAAAATGCCTGCTTGAAGCCTGCCTTGAACTCATGGCTTCCGGTGCGGTCATCGCCAT
TCAGGACATGGGCGCTGCCGGCCTCACCTGCTCGGCGGTCGAGATGGGTGCCAAGGGCGATCTCGGCATCGAACTCATTC
TCGACCATGTTCCCGTTCGCGAAGAGAACATGACCGCCTATGAAATGATGCTTTCGGAAAGCCAGGAGCGCATGCTCATG
GTGCTGAAGCCGGAAAAGGAAGCAGAAGCGCAGGCTATCTTCCGCAAATGGGGCCTTGATTTCGCGATTGTCGGCAAGAC
CACGGACGATCTTCGTTTCCGCGTCATCCATCAGGGGGAAGAGGTCGCCAATCTGCCGATCAAGGATCTGGGCGACGAAG
CGCCGGAATATGATCGCCCGTGGATGGAGCCGGGCAAGCATGCGCCGCTGCCTGCCAGCAATGTGCCGCAGGTGGAAGAC
TATTCCGCAGCCCTGCTGAAGCTGATCGGCTCGCCCGATCTTTCCTCGCGCCGCTGGGTCTATGAACAGTACGACACGCT
CATTCAGGGCAATTCCTTGCAGGTTCCGGGCGGCGACGCCGGTGTAATCCGTGTCGAAGGCCATGAAACCAAGGCTCTCG
CCTTCTCTTCCGACGTGACGCCGCGCTATTGCGAAGCCGATCCGTTTGAAGGCGGCAAGCAGGCCGTTGCCGAATGCTGG
CGCAACATCACGGCGACCGGCGCGGAGCCGCTGGCCTCGACCGATAATCTGAACTTCGGCAATCCCGAAAAGCCGGAAAT
CATGGGCCAGCTCGTCAAGGCTATCGAAGGCATTGGCGAGGCCTGCCGCGCACTCGACTTCCCGATCGTGTCCGGCAATG
TGTCGCTTTACAATGAGACCAACGGCCAGGCCATTCTGCCAACGCCAACGATTGCGGGTGTTGGCCTCCTTCCCGACTGG
TCGCAAATGGCGAAGATCGGCGGCATGCAGGATGGCGATACGCTGGTTCTGCTCGGTGGTGACGGAACGCATCTCGGCCA
GTCGGTCTATCTGCGTGACCTTTTCGACCGCGCGGACGGTCCTGCGCCTTTTGTCGATCTGGCGCTTGAAAAGCGCAATG
GCGAATTTGTCCGTTCTGCCATTCGCAACGGTCAGGTGACGGCCTGCCATGATCTTTCCGATGGCGGTCTGGCGATTGCC
GTTGCCGAAATGGCGATCAAGTCCGGCAAAGGCGCGACGCTGGACGCTGGTGACGGCCTGCCGCACGCCCTGCTTTTCGG
TGAAGATCAGGCACGCTATGTTATTTCCGCCACGCCTGAAATGGCAAAGCTCATCGCGCTTAACGCGGAAGGCGCAGGCG
TTCCATTCCGCATTTTGGGTACAGTTGGCGGCGACCGGCTGAAAATCAGCAAGAATGTCGATGTCAGCGTGGCCGATCTG
ACGCAGGCTTATGAAGGTTGGTTCCCGAACTTCATGAACGGCGAACTGACCGGCAATAACTGA

Upstream 100 bases:

>100_bases
CATGAAAACATAGGTTAAAGAGGCGCCTTGAAACCTTAGGCGCCAGTCTTCGGCAGAAGGCTTTCGGGTGCCACAGCCTG
CGACGGGGTTCCCCATTTCC

Downstream 100 bases:

>100_bases
TCTTATCCTTGGAGCGGTTCCTGTTTTAACAGGATCGCCGGAACCGCTCTGACTGTTTGTTTTATCGCATTGTCCAACGC
AAAACCGTTTCACGCTTTTG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGV
VDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNA
FGVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLM
VLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVED
YSAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDW
SQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIA
VAEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
TQAYEGWFPNFMNGELTGNN

Sequences:

>Translated_740_residues
MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGV
VDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNA
FGVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLM
VLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVED
YSAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDW
SQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIA
VAEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
TQAYEGWFPNFMNGELTGNN
>Mature_739_residues
TISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGVV
DIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAF
GVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQ
VGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLMV
LKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDY
SAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECWR
NITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDWS
QMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAV
AEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADLT
QAYEGWFPNFMNGELTGNN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=672, Percent_Identity=22.7678571428571, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI48994899, Length=806, Percent_Identity=23.3250620347395, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17553022, Length=442, Percent_Identity=23.3031674208145, Blast_Score=80, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321498, Length=742, Percent_Identity=23.8544474393531, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24582111, Length=755, Percent_Identity=23.4437086092715, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24582109, Length=755, Percent_Identity=23.4437086092715, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137292, Length=755, Percent_Identity=23.4437086092715, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79117; Mature: 78986

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTSGPRVIQGPGENAGVVDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAFGVPTVGGEVNFDKRYNGNI
HCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LVNAFAAGLARHDGIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEEEEECCCCC
EENMTAYEMMLSESQERMLMVLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGE
CCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCC
EVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDYSAALLKLIGSPDLSSRRWV
HHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
YEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
HHHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNET
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECC
NGQAILPTPTIAGVGLLPDWSQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADG
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
PAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAVAEMAIKSGKGATLDAGDGL
CCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHCCCCCEEECCCCC
PHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
CEEEEECCCCCCEEEECCHHHEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEHHHH
TQAYEGWFPNFMNGELTGNN
HHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTSGPRVIQGPGENAGVVDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAFGVPTVGGEVNFDKRYNGNI
HCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LVNAFAAGLARHDGIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEEEEECCCCC
EENMTAYEMMLSESQERMLMVLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGE
CCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCC
EVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDYSAALLKLIGSPDLSSRRWV
HHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCH
YEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECW
HHHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
RNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNET
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECC
NGQAILPTPTIAGVGLLPDWSQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADG
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
PAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAVAEMAIKSGKGATLDAGDGL
CCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHCCCCCEEECCCCC
PHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADL
CEEEEECCCCCCEEEECCHHHEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEHHHH
TQAYEGWFPNFMNGELTGNN
HHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA