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The map label for this gene is map [H]

Identifier: 23100849

GI number: 23100849

Start: 3530761

End: 3531501

Strand: Reverse

Name: map [H]

Synonym: OB3394

Alternate gene names: 23100849

Gene position: 3531501-3530761 (Counterclockwise)

Preceding gene: 23100850

Following gene: 23100847

Centisome position: 97.27

GC content: 43.72

Gene sequence:

>741_bases
ATGATTGCAAAGACAGAAGCGGATTTCAACGGATTAAAAGAAATAGGTAAAATTTGTGGAGCGATTCGGGATGAATTGGT
TCGTTCTACCAAACCGGGAATGACTACAAAAGAACTTGATGAAATGGCAGGCACGATGTTTGCACAAGCAGGAGCTCAAT
CGGCGCCAAAAGGAGAGTATGATTTCCCAGGATATACATGCATTAGCATTAATGAAGAAGTAGCGCACGGGATTCCCGGC
GAACGGGTAATTGAGGAAGGCGATATTGTTAACATAGATGTTTCCGGGTCGAAAAATGGTTATTTTGCAGATACGGGAAT
TTCCTTTGTAGCTGGGCAAGGGGAGGAAATGTCACAGAAAGTATGTGATGTGGTAAAAGAAGCATTCGAAGCTGGGTTGG
AGAAGGCAAAACCAGGTGTGAGCACAAGTGCGCTTGGGAAAGCTGCACACAATGTGGCAAAAAAACATGGCTTAACCGTG
ATCAAGAACCTTACCGGACACGGAATTGGCCGCTCGATACATGAAGCGCCAGATCATATTTTCAGTTACTTCTCTCGTTG
GGATAATGAGATTTTAAAAGATGGCATGGTTATCGCCTTTGAGCCATTTATCTCAACATTTGAAGAGCAAGTCTATCAAG
GAGAAGACGGCTGGACCTTCTTAACGGTGGAAAGCGCGGTCGCTCAATACGAACATACTATTATTGTAACGGAAGATGGC
CCAATTATTACGACATTGTAA

Upstream 100 bases:

>100_bases
AATTAAATGTGTTGAAGAAAAAGGTATTTCTTCTATACTAGAATAGGTTCCAAAATATCACAAAGAACATAACATATGTA
AAAAAGTAGGTGTATATACG

Downstream 100 bases:

>100_bases
TTTTGAGTGCGTATTTCTTTAGTGTAAATGTAAGCAGGCGCTGCGGAAAAACACTGCGCTTTCCGTGGTTTTGTCCTCAG
CCTCCTCGAAAAAAGGAGGT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MIAKTEADFNGLKEIGKICGAIRDELVRSTKPGMTTKELDEMAGTMFAQAGAQSAPKGEYDFPGYTCISINEEVAHGIPG
ERVIEEGDIVNIDVSGSKNGYFADTGISFVAGQGEEMSQKVCDVVKEAFEAGLEKAKPGVSTSALGKAAHNVAKKHGLTV
IKNLTGHGIGRSIHEAPDHIFSYFSRWDNEILKDGMVIAFEPFISTFEEQVYQGEDGWTFLTVESAVAQYEHTIIVTEDG
PIITTL

Sequences:

>Translated_246_residues
MIAKTEADFNGLKEIGKICGAIRDELVRSTKPGMTTKELDEMAGTMFAQAGAQSAPKGEYDFPGYTCISINEEVAHGIPG
ERVIEEGDIVNIDVSGSKNGYFADTGISFVAGQGEEMSQKVCDVVKEAFEAGLEKAKPGVSTSALGKAAHNVAKKHGLTV
IKNLTGHGIGRSIHEAPDHIFSYFSRWDNEILKDGMVIAFEPFISTFEEQVYQGEDGWTFLTVESAVAQYEHTIIVTEDG
PIITTL
>Mature_246_residues
MIAKTEADFNGLKEIGKICGAIRDELVRSTKPGMTTKELDEMAGTMFAQAGAQSAPKGEYDFPGYTCISINEEVAHGIPG
ERVIEEGDIVNIDVSGSKNGYFADTGISFVAGQGEEMSQKVCDVVKEAFEAGLEKAKPGVSTSALGKAAHNVAKKHGLTV
IKNLTGHGIGRSIHEAPDHIFSYFSRWDNEILKDGMVIAFEPFISTFEEQVYQGEDGWTFLTVESAVAQYEHTIIVTEDG
PIITTL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=239, Percent_Identity=32.2175732217573, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI40385867, Length=243, Percent_Identity=30.0411522633745, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=36.1788617886179, Blast_Score=170, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI71996291, Length=243, Percent_Identity=31.6872427983539, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323273, Length=241, Percent_Identity=33.6099585062241, Blast_Score=135, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21355531, Length=239, Percent_Identity=30.1255230125523, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=31.7073170731707, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 26569; Mature: 26569

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAKTEADFNGLKEIGKICGAIRDELVRSTKPGMTTKELDEMAGTMFAQAGAQSAPKGEY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DFPGYTCISINEEVAHGIPGERVIEEGDIVNIDVSGSKNGYFADTGISFVAGQGEEMSQK
CCCCEEEEEECHHHHHCCCCHHEECCCCEEEEEECCCCCCEEECCCCEEEECCCHHHHHH
VCDVVKEAFEAGLEKAKPGVSTSALGKAAHNVAKKHGLTVIKNLTGHGIGRSIHEAPDHI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHH
FSYFSRWDNEILKDGMVIAFEPFISTFEEQVYQGEDGWTFLTVESAVAQYEHTIIVTEDG
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCEEEEECCC
PIITTL
CEEECC
>Mature Secondary Structure
MIAKTEADFNGLKEIGKICGAIRDELVRSTKPGMTTKELDEMAGTMFAQAGAQSAPKGEY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DFPGYTCISINEEVAHGIPGERVIEEGDIVNIDVSGSKNGYFADTGISFVAGQGEEMSQK
CCCCEEEEEECHHHHHCCCCHHEECCCCEEEEEECCCCCCEEECCCCEEEECCCHHHHHH
VCDVVKEAFEAGLEKAKPGVSTSALGKAAHNVAKKHGLTVIKNLTGHGIGRSIHEAPDHI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHH
FSYFSRWDNEILKDGMVIAFEPFISTFEEQVYQGEDGWTFLTVESAVAQYEHTIIVTEDG
HHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCEEEEECCC
PIITTL
CEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA