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The map label for this gene is nox [H]

Identifier: 23100767

GI number: 23100767

Start: 3450699

End: 3452066

Strand: Reverse

Name: nox [H]

Synonym: OB3312

Alternate gene names: 23100767

Gene position: 3452066-3450699 (Counterclockwise)

Preceding gene: 23100769

Following gene: 23100765

Centisome position: 95.08

GC content: 42.4

Gene sequence:

>1368_bases
ATGAAAGTAGCAGTAATTGGATGTACACACGCTGGAACAACAGCGATTAAAAATATAGTAAATCTTTATCCTGATGCAGA
GATTGATGTGTTAGAAAGAAATGATAATGTTTCCTTTCTTTCATGCGGGATCGCGCTTTCTGTAGGCGGTGTGGTAGAGA
ATCCAGAGGACCTCTTTTATGCTTCTGTCCCACAATTTGAGCGTTTAGGTGTACGCATGCATATGAACCATGACGTGATT
TCCTGTGACGTAACTGCGAAGCAATTGCAGGCAAAAGATTTAAAAACAGATACAATTAAAAACTATTCCTACGATAAACT
AATTATCGCCTCAGGTTCGTGGCCTATAACGCCGCCAATTCCAGGCGCTGATTTGGAGAATGTGTTGTTATGTAAGAACT
ATGACCATGCAAAAGAAATTATTAACCGATCTGCATCCGTCCGAAATGTAGTCGTTGTCGGCGCTGGATATATTGGTGTG
GAGCTGGTCGAAGCTTTTGAAGAAAACGGTAAAAACGTAACATTAATTGATAGTGAAGAACGAATCTTAAATCGCTATTT
GGATGATATCTTTACCGAACCTGTGGAAGCGAGCTTTGAACAGCGCGGTGTACAATTAGCACTTGGCCAGACGGTTTCCC
AATTTGAAGGAGAAGAAACGGTTGAAAAAGTAATTACCGATAAAGGTGAATATGCCGCAGATTTAGTGGTGATGTGTATT
GGATTTAGACCTAATACGGGCCTGTTTAACAATCAATTGGACATGTTGGGTAATGGTGCGATCGTGGTGGATGCATATAT
GCAAACCAGTGTGAAAGATGTCTTTGCGGCAGGAGATTGCTGTGCTATTTATAACAATGCGACCAAACAGTCTGCCTATA
TCCCATTAGCAACCAACGCAGTGAGAATGGGCACATTAGTCGCGCATAACCTTGTGCGTCCGGTGATGGCGCATCCAGGA
ACGCAAGGCACGTCTGGATTAAAGCTATATCATCATAACATTGCTTCAACTGGATTAACAGAAAGTGCCGCGAGTCTTTC
AGGTGTTTCGGTGGATAGTGTTGTCTATAAAGATAATTATCGACCAGACTTTATGCCAGAAAACGCCGAGATTCAATTAA
AACTGGTCTATGAAACAGAGACACATCGCATCGTTGGTGCGCAGGTGATTTCCGATGCTGATTTCACGCAGGCAATCAAT
ACGATTAGTGTCGGTATCGCCAATAACATGACGGTTGAGCAATTGGCATTGACCGATTTCTTCTTCCAGCCGCATTACAA
TAAACCAGTGAACTTCCTGAATGAAGTGGCACTAAAAGCAATGGCGAAGAAAGCTGGCAAAACGCAAAAACAAGCCGTTC
TTTCCTAA

Upstream 100 bases:

>100_bases
CTGAACAATCTGCTATACTACCATTAAGAATCCTTCAACCAACGGATTCGTCTTAAATTGTGAAATGCTGAACAAAACAA
AAATTGGAGGGTGTTTCGTA

Downstream 100 bases:

>100_bases
AGGATCGTAACTAGCCACAAGAAGTGTGCATTAAAATAACCACTTTTTCTGCACGCTTCTATTGTTTTCCTATATATTTC
ACCGAGGCCATATGGGTTTG

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKVAVIGCTHAGTTAIKNIVNLYPDAEIDVLERNDNVSFLSCGIALSVGGVVENPEDLFYASVPQFERLGVRMHMNHDVI
SCDVTAKQLQAKDLKTDTIKNYSYDKLIIASGSWPITPPIPGADLENVLLCKNYDHAKEIINRSASVRNVVVVGAGYIGV
ELVEAFEENGKNVTLIDSEERILNRYLDDIFTEPVEASFEQRGVQLALGQTVSQFEGEETVEKVITDKGEYAADLVVMCI
GFRPNTGLFNNQLDMLGNGAIVVDAYMQTSVKDVFAAGDCCAIYNNATKQSAYIPLATNAVRMGTLVAHNLVRPVMAHPG
TQGTSGLKLYHHNIASTGLTESAASLSGVSVDSVVYKDNYRPDFMPENAEIQLKLVYETETHRIVGAQVISDADFTQAIN
TISVGIANNMTVEQLALTDFFFQPHYNKPVNFLNEVALKAMAKKAGKTQKQAVLS

Sequences:

>Translated_455_residues
MKVAVIGCTHAGTTAIKNIVNLYPDAEIDVLERNDNVSFLSCGIALSVGGVVENPEDLFYASVPQFERLGVRMHMNHDVI
SCDVTAKQLQAKDLKTDTIKNYSYDKLIIASGSWPITPPIPGADLENVLLCKNYDHAKEIINRSASVRNVVVVGAGYIGV
ELVEAFEENGKNVTLIDSEERILNRYLDDIFTEPVEASFEQRGVQLALGQTVSQFEGEETVEKVITDKGEYAADLVVMCI
GFRPNTGLFNNQLDMLGNGAIVVDAYMQTSVKDVFAAGDCCAIYNNATKQSAYIPLATNAVRMGTLVAHNLVRPVMAHPG
TQGTSGLKLYHHNIASTGLTESAASLSGVSVDSVVYKDNYRPDFMPENAEIQLKLVYETETHRIVGAQVISDADFTQAIN
TISVGIANNMTVEQLALTDFFFQPHYNKPVNFLNEVALKAMAKKAGKTQKQAVLS
>Mature_455_residues
MKVAVIGCTHAGTTAIKNIVNLYPDAEIDVLERNDNVSFLSCGIALSVGGVVENPEDLFYASVPQFERLGVRMHMNHDVI
SCDVTAKQLQAKDLKTDTIKNYSYDKLIIASGSWPITPPIPGADLENVLLCKNYDHAKEIINRSASVRNVVVVGAGYIGV
ELVEAFEENGKNVTLIDSEERILNRYLDDIFTEPVEASFEQRGVQLALGQTVSQFEGEETVEKVITDKGEYAADLVVMCI
GFRPNTGLFNNQLDMLGNGAIVVDAYMQTSVKDVFAAGDCCAIYNNATKQSAYIPLATNAVRMGTLVAHNLVRPVMAHPG
TQGTSGLKLYHHNIASTGLTESAASLSGVSVDSVVYKDNYRPDFMPENAEIQLKLVYETETHRIVGAQVISDADFTQAIN
TISVGIANNMTVEQLALTDFFFQPHYNKPVNFLNEVALKAMAKKAGKTQKQAVLS

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=267, Percent_Identity=31.0861423220974, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI21389617, Length=267, Percent_Identity=31.0861423220974, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI65787454, Length=267, Percent_Identity=31.0861423220974, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI50301238, Length=323, Percent_Identity=25.077399380805, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789065, Length=294, Percent_Identity=27.5510204081633, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789765, Length=396, Percent_Identity=23.2323232323232, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=218, Percent_Identity=30.2752293577982, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24585130, Length=223, Percent_Identity=23.7668161434978, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281359715, Length=180, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281359713, Length=180, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639250, Length=180, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18543267, Length=180, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639252, Length=180, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639257, Length=181, Percent_Identity=26.5193370165746, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573993, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24581020, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49580; Mature: 49580

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAVIGCTHAGTTAIKNIVNLYPDAEIDVLERNDNVSFLSCGIALSVGGVVENPEDLFY
CEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECEEEEECCCCCCCHHHEE
ASVPQFERLGVRMHMNHDVISCDVTAKQLQAKDLKTDTIKNYSYDKLIIASGSWPITPPI
ECCCCHHHCCEEEECCCCEEEECCCHHHHHHHCCCHHHHCCCCCCEEEEECCCCCCCCCC
PGADLENVLLCKNYDHAKEIINRSASVRNVVVVGAGYIGVELVEAFEENGKNVTLIDSEE
CCCCCCCEEEECCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCHH
RILNRYLDDIFTEPVEASFEQRGVQLALGQTVSQFEGEETVEKVITDKGEYAADLVVMCI
HHHHHHHHHHHCCCHHHHHHHCCEEEEECCHHHHCCCHHHHHHHHCCCCCHHHEEEEEEE
GFRPNTGLFNNQLDMLGNGAIVVDAYMQTSVKDVFAAGDCCAIYNNATKQSAYIPLATNA
ECCCCCCCCCCCHHHCCCCEEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCH
VRMGTLVAHNLVRPVMAHPGTQGTSGLKLYHHNIASTGLTESAASLSGVSVDSVVYKDNY
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEEEECCC
RPDFMPENAEIQLKLVYETETHRIVGAQVISDADFTQAINTISVGIANNMTVEQLALTDF
CCCCCCCCCCEEEEEEEECCCCEEEEHHHHCCCHHHHHHHHEEEECCCCCCHHHHHHHHH
FFQPHYNKPVNFLNEVALKAMAKKAGKTQKQAVLS
HCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MKVAVIGCTHAGTTAIKNIVNLYPDAEIDVLERNDNVSFLSCGIALSVGGVVENPEDLFY
CEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECEEEEECCCCCCCHHHEE
ASVPQFERLGVRMHMNHDVISCDVTAKQLQAKDLKTDTIKNYSYDKLIIASGSWPITPPI
ECCCCHHHCCEEEECCCCEEEECCCHHHHHHHCCCHHHHCCCCCCEEEEECCCCCCCCCC
PGADLENVLLCKNYDHAKEIINRSASVRNVVVVGAGYIGVELVEAFEENGKNVTLIDSEE
CCCCCCCEEEECCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCHH
RILNRYLDDIFTEPVEASFEQRGVQLALGQTVSQFEGEETVEKVITDKGEYAADLVVMCI
HHHHHHHHHHHCCCHHHHHHHCCEEEEECCHHHHCCCHHHHHHHHCCCCCHHHEEEEEEE
GFRPNTGLFNNQLDMLGNGAIVVDAYMQTSVKDVFAAGDCCAIYNNATKQSAYIPLATNA
ECCCCCCCCCCCHHHCCCCEEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCH
VRMGTLVAHNLVRPVMAHPGTQGTSGLKLYHHNIASTGLTESAASLSGVSVDSVVYKDNY
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEEEECCC
RPDFMPENAEIQLKLVYETETHRIVGAQVISDADFTQAINTISVGIANNMTVEQLALTDF
CCCCCCCCCCEEEEEEEECCCCEEEEHHHHCCCHHHHHHHHEEEECCCCCCHHHHHHHHH
FFQPHYNKPVNFLNEVALKAMAKKAGKTQKQAVLS
HCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]