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The map label for this gene is panE [C]

Identifier: 23100728

GI number: 23100728

Start: 3409809

End: 3410666

Strand: Reverse

Name: panE [C]

Synonym: OB3273

Alternate gene names: 23100728

Gene position: 3410666-3409809 (Counterclockwise)

Preceding gene: 23100731

Following gene: 23100725

Centisome position: 93.94

GC content: 42.07

Gene sequence:

>858_bases
ATGAAAAAGTTTGGAGTTATCGGACCAGGGGCAGTTGGTTCCGTAATTGCGGAATCTCTGTTGCAACATGGTCTTCAGGT
ACATTTATTAGGAAGAAATGCTGGAGAAGTACGTATCGAGCGGAAAGGGCAGTTGGCGGAAAGTACACTGCTCGTAGAAG
AACTATCCCGTTTTGAAACCACGCTGGATTATATTTTTATCACAGTAAAAGGCACACAGCTATCGGCAGTGCTTCCATTT
GTAGAAAAGCTCTCTCATGAAAATACAGTAACGATCATTTGTCAAAATGGCTATGGGCAACTCGAACAGATAACTATGCC
ACATACCTATCAAGCCGTCGTGTATATCAGCGGACAAAAAAAGGACCAAACGATAACGCATTTTCGTGATCGGAAATTAA
TTTTACCTGAAAATGAAGACACAATCGCCCTACATCAACTAGTTGAAGGAAGTGACCTCGATATCCAAATTAGCCCCCAT
TATCTTCACGATATATGGTTTAAGCTGCTCGTCAATCTCGGGATTAATTCTGTCACTGCATTGAGCCGGAATACTGCAAT
TGTTGTAACGAATGAAAAGGTCAGAAACCTGTGTGAATCATTGATTAAAGAGGGAATGACGATTGCTCATGCGGAAGGGA
TCCATTTTGAGAAATCTACCGTACAAGCCATCATGGATATTTACGATGGCTACCCGCCGCATATGGGCACGAGTATGTAT
TACGATCAGTTAAATCGTAACCCAATGGAAATCGATTATATTCAAGGATTCTTATATCGGAAAAGTCAGAAGCACCACTT
AGACACGCCACATGTAGACACGGTTTACAGCTTGTTGGTGGCGAGTGAGATAAGGTGA

Upstream 100 bases:

>100_bases
GCCTTCATTTTTCGTCACCTACTATTTTTATTCTTGTACTTATTATAGAATTATCTGTATAGATTAACAATGCGTTTGAT
AGTTGAAAAGGAGCTTAGCT

Downstream 100 bases:

>100_bases
AGACTGCATCTGCAAGTGTAGCGTTTTAGTAAGATTGTCTATTTTTTTTAAGAAGTGCTCTATTACCTAAAAGTTTTGCG
TATTGCTCAAGAATTGGTCA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKKFGVIGPGAVGSVIAESLLQHGLQVHLLGRNAGEVRIERKGQLAESTLLVEELSRFETTLDYIFITVKGTQLSAVLPF
VEKLSHENTVTIICQNGYGQLEQITMPHTYQAVVYISGQKKDQTITHFRDRKLILPENEDTIALHQLVEGSDLDIQISPH
YLHDIWFKLLVNLGINSVTALSRNTAIVVTNEKVRNLCESLIKEGMTIAHAEGIHFEKSTVQAIMDIYDGYPPHMGTSMY
YDQLNRNPMEIDYIQGFLYRKSQKHHLDTPHVDTVYSLLVASEIR

Sequences:

>Translated_285_residues
MKKFGVIGPGAVGSVIAESLLQHGLQVHLLGRNAGEVRIERKGQLAESTLLVEELSRFETTLDYIFITVKGTQLSAVLPF
VEKLSHENTVTIICQNGYGQLEQITMPHTYQAVVYISGQKKDQTITHFRDRKLILPENEDTIALHQLVEGSDLDIQISPH
YLHDIWFKLLVNLGINSVTALSRNTAIVVTNEKVRNLCESLIKEGMTIAHAEGIHFEKSTVQAIMDIYDGYPPHMGTSMY
YDQLNRNPMEIDYIQGFLYRKSQKHHLDTPHVDTVYSLLVASEIR
>Mature_285_residues
MKKFGVIGPGAVGSVIAESLLQHGLQVHLLGRNAGEVRIERKGQLAESTLLVEELSRFETTLDYIFITVKGTQLSAVLPF
VEKLSHENTVTIICQNGYGQLEQITMPHTYQAVVYISGQKKDQTITHFRDRKLILPENEDTIALHQLVEGSDLDIQISPH
YLHDIWFKLLVNLGINSVTALSRNTAIVVTNEKVRNLCESLIKEGMTIAHAEGIHFEKSTVQAIMDIYDGYPPHMGTSMY
YDQLNRNPMEIDYIQGFLYRKSQKHHLDTPHVDTVYSLLVASEIR

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32183; Mature: 32183

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFGVIGPGAVGSVIAESLLQHGLQVHLLGRNAGEVRIERKGQLAESTLLVEELSRFET
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHH
TLDYIFITVKGTQLSAVLPFVEKLSHENTVTIICQNGYGQLEQITMPHTYQAVVYISGQK
EEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCEEEEEEEECCC
KDQTITHFRDRKLILPENEDTIALHQLVEGSDLDIQISPHYLHDIWFKLLVNLGINSVTA
CCCHHHHHCCCEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEE
LSRNTAIVVTNEKVRNLCESLIKEGMTIAHAEGIHFEKSTVQAIMDIYDGYPPHMGTSMY
ECCCCEEEEECHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHH
YDQLNRNPMEIDYIQGFLYRKSQKHHLDTPHVDTVYSLLVASEIR
HHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKFGVIGPGAVGSVIAESLLQHGLQVHLLGRNAGEVRIERKGQLAESTLLVEELSRFET
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHH
TLDYIFITVKGTQLSAVLPFVEKLSHENTVTIICQNGYGQLEQITMPHTYQAVVYISGQK
EEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCEEEEEEEECCC
KDQTITHFRDRKLILPENEDTIALHQLVEGSDLDIQISPHYLHDIWFKLLVNLGINSVTA
CCCHHHHHCCCEEECCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEE
LSRNTAIVVTNEKVRNLCESLIKEGMTIAHAEGIHFEKSTVQAIMDIYDGYPPHMGTSMY
ECCCCEEEEECHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHH
YDQLNRNPMEIDYIQGFLYRKSQKHHLDTPHVDTVYSLLVASEIR
HHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]