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The map label for this gene is tdcB [H]

Identifier: 23100071

GI number: 23100071

Start: 2678992

End: 2680008

Strand: Reverse

Name: tdcB [H]

Synonym: OB2616

Alternate gene names: 23100071

Gene position: 2680008-2678992 (Counterclockwise)

Preceding gene: 23100072

Following gene: 23100070

Centisome position: 73.82

GC content: 37.76

Gene sequence:

>1017_bases
GTGAGTTGTCTTGGGGATCGCTTAACTGGTGAAAAAGTATACCAAGCTATGAAGAAATTAACACCGATTGTTCATCGTAC
ACCATTAGTAACATCACATACAACGGATGATATTGTTGGAAAACATGTTTACTGTAAAATGGAAAATCAACAAAAAACTG
GGGCATTTAAATTTCGAGGAGCAAGTTATAAATTAATGCAACTGTCAAAAGAAGAATTACAACACGGCGTAATTACAGCT
TCAGCTGGTAATCATGCACAAGGTGTAGCTCATGCCGCTGCAAAATTAGGAGTTAAGGCAACGATTTTTATGTCTGAAGG
AACGCCTCTAGCGAAAATTAATGCGACAAGAAATTATGGGGCAACCGTAAATCTTGTTGGAGAAAGTTTTCAAGAAGCTT
ATGAGGCTTCACTTCAACATCAAAAAGTAACTGGTGCTACGTATATCCACCCATTTGATGATTATGATATTATGGCTGGT
CAAGGGACAATTGCAATGGAATTACTCCGCCAAGAAGACCGTATTGATACCATTATTGTCCCAATTGGTGGAGGTGGATT
AATTAGTGGCATTGCAGTTGCTGCTAAACATGTAAATAGAAACATTAAAATAATCGGCGTACAGGCTGAAGGTGCTGCAG
CAATGCATCAAAGTTATCATTCGAGCAAAGTACATTCTTTATCAAATGTTTCAACAATTGCAGAAGGAATAGCGGTAAAA
CAACCAGGAGATTTGACCTTGCCACTTATTCGATCCTATGTTGATGATATTGTTACGGTTAATGATGAACAAATTGCTTC
AGCAATCATTTACATGTTGGAAAGAAATAAGACGTTAATGGAAGGTGCTGGTGCCGCTGCATTAGCTGCACTATTTGCAC
ATAATGACACGATCTCATCCAGGCATTGTGGTGTTATAGTTAGTGGAGGTAACTTGGACATCAGTAATATGCAAAAAATA
CAACATCTATCCAGTAATATTAATAAAAATCCAGAAAGAGCATATGTGGCGCTATAA

Upstream 100 bases:

>100_bases
ACCTTATTAAAGGAAGAAAAGATTGCGGCCTATGAATCTGCTAACTGAGATTTATTCCGCTGAATAAAGTTTCATTTTTT
CGTTACAGAATAGAAGGAGA

Downstream 100 bases:

>100_bases
AAGGAAAAGTCTTTTGACCTAGGAAAAAGGTTAAAAGACTTTTTCTGTGTATAAGAAAATTAGATTGATAGATAATAAAG
TTAAATTCGAGAAAAGCGAA

Product: truncated threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSCLGDRLTGEKVYQAMKKLTPIVHRTPLVTSHTTDDIVGKHVYCKMENQQKTGAFKFRGASYKLMQLSKEELQHGVITA
SAGNHAQGVAHAAAKLGVKATIFMSEGTPLAKINATRNYGATVNLVGESFQEAYEASLQHQKVTGATYIHPFDDYDIMAG
QGTIAMELLRQEDRIDTIIVPIGGGGLISGIAVAAKHVNRNIKIIGVQAEGAAAMHQSYHSSKVHSLSNVSTIAEGIAVK
QPGDLTLPLIRSYVDDIVTVNDEQIASAIIYMLERNKTLMEGAGAAALAALFAHNDTISSRHCGVIVSGGNLDISNMQKI
QHLSSNINKNPERAYVAL

Sequences:

>Translated_338_residues
MSCLGDRLTGEKVYQAMKKLTPIVHRTPLVTSHTTDDIVGKHVYCKMENQQKTGAFKFRGASYKLMQLSKEELQHGVITA
SAGNHAQGVAHAAAKLGVKATIFMSEGTPLAKINATRNYGATVNLVGESFQEAYEASLQHQKVTGATYIHPFDDYDIMAG
QGTIAMELLRQEDRIDTIIVPIGGGGLISGIAVAAKHVNRNIKIIGVQAEGAAAMHQSYHSSKVHSLSNVSTIAEGIAVK
QPGDLTLPLIRSYVDDIVTVNDEQIASAIIYMLERNKTLMEGAGAAALAALFAHNDTISSRHCGVIVSGGNLDISNMQKI
QHLSSNINKNPERAYVAL
>Mature_337_residues
SCLGDRLTGEKVYQAMKKLTPIVHRTPLVTSHTTDDIVGKHVYCKMENQQKTGAFKFRGASYKLMQLSKEELQHGVITAS
AGNHAQGVAHAAAKLGVKATIFMSEGTPLAKINATRNYGATVNLVGESFQEAYEASLQHQKVTGATYIHPFDDYDIMAGQ
GTIAMELLRQEDRIDTIIVPIGGGGLISGIAVAAKHVNRNIKIIGVQAEGAAAMHQSYHSSKVHSLSNVSTIAEGIAVKQ
PGDLTLPLIRSYVDDIVTVNDEQIASAIIYMLERNKTLMEGAGAAALAALFAHNDTISSRHCGVIVSGGNLDISNMQKIQ
HLSSNINKNPERAYVAL

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=300, Percent_Identity=34, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI33469958, Length=324, Percent_Identity=30.8641975308642, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI19923959, Length=318, Percent_Identity=27.9874213836478, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1789505, Length=312, Percent_Identity=39.7435897435897, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1790207, Length=298, Percent_Identity=38.9261744966443, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1789235, Length=270, Percent_Identity=23.7037037037037, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=293, Percent_Identity=38.2252559726962, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=311, Percent_Identity=29.2604501607717, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17537387, Length=293, Percent_Identity=35.4948805460751, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322631, Length=302, Percent_Identity=37.4172185430464, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320930, Length=310, Percent_Identity=34.5161290322581, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=286, Percent_Identity=23.0769230769231, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355833, Length=293, Percent_Identity=38.9078498293515, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24645328, Length=214, Percent_Identity=35.5140186915888, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 36288; Mature: 36157

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCLGDRLTGEKVYQAMKKLTPIVHRTPLVTSHTTDDIVGKHVYCKMENQQKTGAFKFRG
CCCCCCCCCHHHHHHHHHHHCHHHHCCCCEECCCCHHHHCCEEEEEECCCCCCCCEEECC
ASYKLMQLSKEELQHGVITASAGNHAQGVAHAAAKLGVKATIFMSEGTPLAKINATRNYG
CCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCC
ATVNLVGESFQEAYEASLQHQKVTGATYIHPFDDYDIMAGQGTIAMELLRQEDRIDTIIV
CEEEEHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCCEEEE
PIGGGGLISGIAVAAKHVNRNIKIIGVQAEGAAAMHQSYHSSKVHSLSNVSTIAEGIAVK
EECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEC
QPGDLTLPLIRSYVDDIVTVNDEQIASAIIYMLERNKTLMEGAGAAALAALFAHNDTISS
CCCCCCHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCC
RHCGVIVSGGNLDISNMQKIQHLSSNINKNPERAYVAL
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SCLGDRLTGEKVYQAMKKLTPIVHRTPLVTSHTTDDIVGKHVYCKMENQQKTGAFKFRG
CCCCCCCCHHHHHHHHHHHCHHHHCCCCEECCCCHHHHCCEEEEEECCCCCCCCEEECC
ASYKLMQLSKEELQHGVITASAGNHAQGVAHAAAKLGVKATIFMSEGTPLAKINATRNYG
CCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCCCC
ATVNLVGESFQEAYEASLQHQKVTGATYIHPFDDYDIMAGQGTIAMELLRQEDRIDTIIV
CEEEEHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCCEEEE
PIGGGGLISGIAVAAKHVNRNIKIIGVQAEGAAAMHQSYHSSKVHSLSNVSTIAEGIAVK
EECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEC
QPGDLTLPLIRSYVDDIVTVNDEQIASAIIYMLERNKTLMEGAGAAALAALFAHNDTISS
CCCCCCHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCC
RHCGVIVSGGNLDISNMQKIQHLSSNINKNPERAYVAL
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA