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The map label for this gene is pcp

Identifier: 23099994

GI number: 23099994

Start: 2593440

End: 2594039

Strand: Reverse

Name: pcp

Synonym: OB2539

Alternate gene names: 23099994

Gene position: 2594039-2593440 (Counterclockwise)

Preceding gene: 23099996

Following gene: 23099993

Centisome position: 71.45

GC content: 35.17

Gene sequence:

>600_bases
ATGAAAAAAATATTGTTAACTGGGTTTGTACCTTTTTTAGATAACCCAATTAACCCAACTGAAGAGATTGTTCAAGGACT
ACATAAAAAAAGTGTGAATGGATGGGAAGTTGTAGGAGAAGTACTTCCTGTAGATTTTCACGTAACCGGAGATCATTTAG
TAGAATTGATACATAAAGTACAACCTAGCGCAATAATATCATTAGGTTTAGCAGCTGGGCGTAATCGAATAACTCCAGAG
AGAATAGCAATTAATTGTAATGACGGCCCTGTAGATAATCAAGGTTATAAACCTGATGGCGAAAAAATCATAAGTGATGG
GCCAGATGGTTATTTTAGTTCGTTACCGATTAAAAAAATGGTGAAAGAATTAGAAAATAACGGTATACCTGCAAAAATAT
CTAATACTGCCGGAGCTTATTTATGTAATCATGTGATGTATCGTGCACTGCATGAAATAGAACAACAAAAGTTAGATATT
TTTTCTGGGTTTATTCACATTCCAGCATCCCACAAGCTAGCACTAACAAATAATATCCCGAGTTTTGCGCAAAAGGATCT
TCAGCGCGCTATAGAAATTTGCATTGGATGTCTAGATTAA

Upstream 100 bases:

>100_bases
ATCAGACTCGTTCAAAATACCGTCATAATTAAAATTTAAATCGTCGAAATTAATTCATTATTTTGATAGAATTAAAGTAA
ATGAAGAGAGGGGCAATGTC

Downstream 100 bases:

>100_bases
TGCAAACTAATCCAATTATTAAAGTTCCTCCCACGAGATTAGAAGTAATCATGCACATTCTAACTTATTTTGGAATAATT
GTAATGTGTATTTATATTGG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MKKILLTGFVPFLDNPINPTEEIVQGLHKKSVNGWEVVGEVLPVDFHVTGDHLVELIHKVQPSAIISLGLAAGRNRITPE
RIAINCNDGPVDNQGYKPDGEKIISDGPDGYFSSLPIKKMVKELENNGIPAKISNTAGAYLCNHVMYRALHEIEQQKLDI
FSGFIHIPASHKLALTNNIPSFAQKDLQRAIEICIGCLD

Sequences:

>Translated_199_residues
MKKILLTGFVPFLDNPINPTEEIVQGLHKKSVNGWEVVGEVLPVDFHVTGDHLVELIHKVQPSAIISLGLAAGRNRITPE
RIAINCNDGPVDNQGYKPDGEKIISDGPDGYFSSLPIKKMVKELENNGIPAKISNTAGAYLCNHVMYRALHEIEQQKLDI
FSGFIHIPASHKLALTNNIPSFAQKDLQRAIEICIGCLD
>Mature_199_residues
MKKILLTGFVPFLDNPINPTEEIVQGLHKKSVNGWEVVGEVLPVDFHVTGDHLVELIHKVQPSAIISLGLAAGRNRITPE
RIAINCNDGPVDNQGYKPDGEKIISDGPDGYFSSLPIKKMVKELENNGIPAKISNTAGAYLCNHVMYRALHEIEQQKLDI
FSGFIHIPASHKLALTNNIPSFAQKDLQRAIEICIGCLD

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_OCEIH (Q8ENE4)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693460.1
- ProteinModelPortal:   Q8ENE4
- SMR:   Q8ENE4
- MEROPS:   C15.001
- GeneID:   1016656
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2539
- NMPDR:   fig|221109.1.peg.2538
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   OIHE221109:OB2539-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 21883; Mature: 21883

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 142-142 ACT_SITE 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILLTGFVPFLDNPINPTEEIVQGLHKKSVNGWEVVGEVLPVDFHVTGDHLVELIHKV
CCCEEEECCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECHHHHHHHHHHH
QPSAIISLGLAAGRNRITPERIAINCNDGPVDNQGYKPDGEKIISDGPDGYFSSLPIKKM
CCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHCCCCCCCCHHCCCHHHH
VKELENNGIPAKISNTAGAYLCNHVMYRALHEIEQQKLDIFSGFIHIPASHKLALTNNIP
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCC
SFAQKDLQRAIEICIGCLD
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKILLTGFVPFLDNPINPTEEIVQGLHKKSVNGWEVVGEVLPVDFHVTGDHLVELIHKV
CCCEEEECCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECHHHHHHHHHHH
QPSAIISLGLAAGRNRITPERIAINCNDGPVDNQGYKPDGEKIISDGPDGYFSSLPIKKM
CCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHCCCCCCCCHHCCCHHHH
VKELENNGIPAKISNTAGAYLCNHVMYRALHEIEQQKLDIFSGFIHIPASHKLALTNNIP
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCC
SFAQKDLQRAIEICIGCLD
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376