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The map label for this gene is uvrB

Identifier: 23099943

GI number: 23099943

Start: 2544353

End: 2546335

Strand: Reverse

Name: uvrB

Synonym: OB2488

Alternate gene names: 23099943

Gene position: 2546335-2544353 (Counterclockwise)

Preceding gene: 23099944

Following gene: 23099942

Centisome position: 70.14

GC content: 36.76

Gene sequence:

>1983_bases
GTGAAGGAGAAATTTGAATTAGTATCTGCTTATGATCCAGCTGGTGATCAACCCAATGCAATAAATGAGATAACGAAAAA
GGTATTAGCTGGTCAACGCCATCAAACATTGCTAGGTGCTACAGGTACCGGAAAGACATTTACAATGTCCAATGTTGTAA
AAGAGATAAATCGTCCGACGTTAGTAATTGCGCATAATAAAACATTAGCTGGACAGCTATACAGTGAGTTTAAAGAGTTT
TTTCCAAATAATGCTGTAGAATACTTTGTTAGCTATTATGATTATTATCAACCAGAGGCATATGTACCGTCTACAGATAC
ATTTATTGAGAAAGATGCGAGTATCAATGATGAAATTGATAAATTACGACATTCCGCAACATCAGCATTGTTTGAGAGAC
AAGATGTATTAATTGTAGCAAGTGTGTCATGTATTTATGGTTTAGGTAATCCGGAAGAATATAAGAGTCAAGTGTTGTCG
TTACGAATGGGAATGGAAAAAGATCGTGACCAATTGCTTCGTGATTTAGTAGAAGTTCAGTATGCTAGAAATGATATTAA
TTTCCAACGTGGTACATTTCGAGTTCGCGGTGATTCTGTAGAGATTATCCCAGCGTCCCATGAAGAATATTGTATCCGTG
TAGAATTTTTTGGTGATGAAATTGACCGTATACGTGAAGTTGATGCACTAACCGGTGAAATAATCGGTGATCGAGAACAT
GTAGCCATTTTTCCAGCTTCTCACTTTGTTACGAGAGAAGAAAAAATGAAAATTGCTATTCAAAATATAGAAAAAGAACT
TGAGGAACAACTAAAAGAAATGCGTGATAATGGGAAGTTATTAGAAGCACAACGATTAGAGCAACGCACCAATTATGATT
TAGAAATGATGCGTGAAATGGGGTTTTGTTCAGGGATTGAGAATTATTCAAGACACTTGACATTACGTGGACCTGGAGCG
GTACCCTATACATTATTGGATTTCTTTCCGGAGGATTTTCTAGTAATTATTGATGAATCGCACGTAACCCTCCCTCAGAT
TCGTGGAATGTTCAATGGGGACCAAGCCCGTAAACAAGTGCTTGTTGATCATGGTTTTCGTTTGCCGTCTGCCATGGATA
ATCGTCCGCTTCGCTTTCAAGAGTTTGAAGATAAAACAAAACAGTTGGTTTATGTTTCAGCGACTCCAGGCCCATATGAA
CTTGAACATTCGCCTGAAATGACAGAACAAATTATTCGACCTACTGGTTTATTAGATCCAAAAGTTGAGGTGCGCCCAAT
TGAAGGACAAATTGATAATCTAATAGAAGAAATTCGTATTCGAATGGAAAAGAATGAGCGAGTATTGATCACGACACTAA
CCAAAAAAATGTCGGAAGATTTAACTGATTATTTGAAAGAAATTGGTATGAAAGTGGCATATTTGCACTCCGAAATTAAA
ACCTTAGAACGTATAGAAGTGATTCGTGATTTACGAGTAGGAAAATTTGATGTGTTAGTAGGCATCAACTTATTAAGAGA
AGGTTTAGATATACCTGAAGTATCGCTTGTTTCAATTTTAGATGCCGATAAAGAAGGATTTTTACGTTCAGAACGATCGC
TTATTCAAACGATGGGGCGTGCTGCACGTAACGAAAATGGAAAAGTAATCATGTATGCAGATAAAATGACGGACTCGATG
AAAAAAGCAATTGATGAGACGAATCGACGTCGAACAATACAAACAGAATATAATGAACAACATGGTATTACGCCTAAAAC
GATTCGGAAAGAAGTTCGAGATGTTATTAAAGCAACGACTGCTGCAGAAGAAACAGAATCATATGAACCGAAAACGAAAC
AGATTAACAAAATGACGAAAAAAGAGAGAGAAAAAGTAATTGAACAAATGGAAAACGAGATGAAGCAAGCAGCAAAAGAT
CTTGATTTTGAGAAAGCAGCAGAATTAAGAGATGTCATTTTGGAACTAAAAGCGGAAGGATGA

Upstream 100 bases:

>100_bases
GGTAGAATATAAGATAGGATAAATCAAAAAACGAATACTTGTTCGTTTTTTTATAAAGAGATATAATAGATATTAGCTCG
AAAAGAACGGAGGCATTGTT

Downstream 100 bases:

>100_bases
TTTTGGAATGCAAAGTAAGTCTATAAAAATTCAAGGAGCACGAACTCATAATTTAAAGGATATCGATATTGATATCCCTA
AAAATAAATTAGTAGTACTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MKEKFELVSAYDPAGDQPNAINEITKKVLAGQRHQTLLGATGTGKTFTMSNVVKEINRPTLVIAHNKTLAGQLYSEFKEF
FPNNAVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDKLRHSATSALFERQDVLIVASVSCIYGLGNPEEYKSQVLS
LRMGMEKDRDQLLRDLVEVQYARNDINFQRGTFRVRGDSVEIIPASHEEYCIRVEFFGDEIDRIREVDALTGEIIGDREH
VAIFPASHFVTREEKMKIAIQNIEKELEEQLKEMRDNGKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSRHLTLRGPGA
VPYTLLDFFPEDFLVIIDESHVTLPQIRGMFNGDQARKQVLVDHGFRLPSAMDNRPLRFQEFEDKTKQLVYVSATPGPYE
LEHSPEMTEQIIRPTGLLDPKVEVRPIEGQIDNLIEEIRIRMEKNERVLITTLTKKMSEDLTDYLKEIGMKVAYLHSEIK
TLERIEVIRDLRVGKFDVLVGINLLREGLDIPEVSLVSILDADKEGFLRSERSLIQTMGRAARNENGKVIMYADKMTDSM
KKAIDETNRRRTIQTEYNEQHGITPKTIRKEVRDVIKATTAAEETESYEPKTKQINKMTKKEREKVIEQMENEMKQAAKD
LDFEKAAELRDVILELKAEG

Sequences:

>Translated_660_residues
MKEKFELVSAYDPAGDQPNAINEITKKVLAGQRHQTLLGATGTGKTFTMSNVVKEINRPTLVIAHNKTLAGQLYSEFKEF
FPNNAVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDKLRHSATSALFERQDVLIVASVSCIYGLGNPEEYKSQVLS
LRMGMEKDRDQLLRDLVEVQYARNDINFQRGTFRVRGDSVEIIPASHEEYCIRVEFFGDEIDRIREVDALTGEIIGDREH
VAIFPASHFVTREEKMKIAIQNIEKELEEQLKEMRDNGKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSRHLTLRGPGA
VPYTLLDFFPEDFLVIIDESHVTLPQIRGMFNGDQARKQVLVDHGFRLPSAMDNRPLRFQEFEDKTKQLVYVSATPGPYE
LEHSPEMTEQIIRPTGLLDPKVEVRPIEGQIDNLIEEIRIRMEKNERVLITTLTKKMSEDLTDYLKEIGMKVAYLHSEIK
TLERIEVIRDLRVGKFDVLVGINLLREGLDIPEVSLVSILDADKEGFLRSERSLIQTMGRAARNENGKVIMYADKMTDSM
KKAIDETNRRRTIQTEYNEQHGITPKTIRKEVRDVIKATTAAEETESYEPKTKQINKMTKKEREKVIEQMENEMKQAAKD
LDFEKAAELRDVILELKAEG
>Mature_660_residues
MKEKFELVSAYDPAGDQPNAINEITKKVLAGQRHQTLLGATGTGKTFTMSNVVKEINRPTLVIAHNKTLAGQLYSEFKEF
FPNNAVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDKLRHSATSALFERQDVLIVASVSCIYGLGNPEEYKSQVLS
LRMGMEKDRDQLLRDLVEVQYARNDINFQRGTFRVRGDSVEIIPASHEEYCIRVEFFGDEIDRIREVDALTGEIIGDREH
VAIFPASHFVTREEKMKIAIQNIEKELEEQLKEMRDNGKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSRHLTLRGPGA
VPYTLLDFFPEDFLVIIDESHVTLPQIRGMFNGDQARKQVLVDHGFRLPSAMDNRPLRFQEFEDKTKQLVYVSATPGPYE
LEHSPEMTEQIIRPTGLLDPKVEVRPIEGQIDNLIEEIRIRMEKNERVLITTLTKKMSEDLTDYLKEIGMKVAYLHSEIK
TLERIEVIRDLRVGKFDVLVGINLLREGLDIPEVSLVSILDADKEGFLRSERSLIQTMGRAARNENGKVIMYADKMTDSM
KKAIDETNRRRTIQTEYNEQHGITPKTIRKEVRDVIKATTAAEETESYEPKTKQINKMTKKEREKVIEQMENEMKQAAKD
LDFEKAAELRDVILELKAEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=58.1081081081081, Blast_Score=775, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_OCEIH (Q8ENJ5)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693409.1
- ProteinModelPortal:   Q8ENJ5
- SMR:   Q8ENJ5
- GeneID:   1017182
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2488
- NMPDR:   fig|221109.1.peg.2487
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   OIHE221109:OB2488-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76038; Mature: 76038

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKFELVSAYDPAGDQPNAINEITKKVLAGQRHQTLLGATGTGKTFTMSNVVKEINRPT
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEHHHHHHHCCCCE
LVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEID
EEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCHHHH
KLRHSATSALFERQDVLIVASVSCIYGLGNPEEYKSQVLSLRMGMEKDRDQLLRDLVEVQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YARNDINFQRGTFRVRGDSVEIIPASHEEYCIRVEFFGDEIDRIREVDALTGEIIGDREH
HHHCCCCCCCCEEEEECCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCE
VAIFPASHFVTREEKMKIAIQNIEKELEEQLKEMRDNGKLLEAQRLEQRTNYDLEMMREM
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHH
GFCSGIENYSRHLTLRGPGAVPYTLLDFFPEDFLVIIDESHVTLPQIRGMFNGDQARKQV
HHHCCCCHHHCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCHHHHHHH
LVDHGFRLPSAMDNRPLRFQEFEDKTKQLVYVSATPGPYELEHSPEMTEQIIRPTGLLDP
HHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
KVEVRPIEGQIDNLIEEIRIRMEKNERVLITTLTKKMSEDLTDYLKEIGMKVAYLHSEIK
CCEEEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TLERIEVIRDLRVGKFDVLVGINLLREGLDIPEVSLVSILDADKEGFLRSERSLIQTMGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
AARNENGKVIMYADKMTDSMKKAIDETNRRRTIQTEYNEQHGITPKTIRKEVRDVIKATT
HHCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
AAEETESYEPKTKQINKMTKKEREKVIEQMENEMKQAAKDLDFEKAAELRDVILELKAEG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKEKFELVSAYDPAGDQPNAINEITKKVLAGQRHQTLLGATGTGKTFTMSNVVKEINRPT
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEHHHHHHHCCCCE
LVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEID
EEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCHHHH
KLRHSATSALFERQDVLIVASVSCIYGLGNPEEYKSQVLSLRMGMEKDRDQLLRDLVEVQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YARNDINFQRGTFRVRGDSVEIIPASHEEYCIRVEFFGDEIDRIREVDALTGEIIGDREH
HHHCCCCCCCCEEEEECCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCE
VAIFPASHFVTREEKMKIAIQNIEKELEEQLKEMRDNGKLLEAQRLEQRTNYDLEMMREM
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHH
GFCSGIENYSRHLTLRGPGAVPYTLLDFFPEDFLVIIDESHVTLPQIRGMFNGDQARKQV
HHHCCCCHHHCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHCCCCCHHHHHHH
LVDHGFRLPSAMDNRPLRFQEFEDKTKQLVYVSATPGPYELEHSPEMTEQIIRPTGLLDP
HHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
KVEVRPIEGQIDNLIEEIRIRMEKNERVLITTLTKKMSEDLTDYLKEIGMKVAYLHSEIK
CCEEEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TLERIEVIRDLRVGKFDVLVGINLLREGLDIPEVSLVSILDADKEGFLRSERSLIQTMGR
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
AARNENGKVIMYADKMTDSMKKAIDETNRRRTIQTEYNEQHGITPKTIRKEVRDVIKATT
HHCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
AAEETESYEPKTKQINKMTKKEREKVIEQMENEMKQAAKDLDFEKAAELRDVILELKAEG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376