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The map label for this gene is yisK [H]

Identifier: 23099899

GI number: 23099899

Start: 2500138

End: 2501043

Strand: Reverse

Name: yisK [H]

Synonym: OB2444

Alternate gene names: 23099899

Gene position: 2501043-2500138 (Counterclockwise)

Preceding gene: 23099900

Following gene: 23099898

Centisome position: 68.89

GC content: 34.66

Gene sequence:

>906_bases
ATGAAACTTGTAAGTTATCGAAAAAAAGAATCCGACTCTAGTTTTCGTATGGGTTTTATCACGGACAATGAAGAAGTAGT
GGATGTACATCTTGCATCACAACATGCAATCCAAGCCGGAAATACAACGATAGAATTACCTTTTCAACCTGAGTTATTTT
ATCAAAAAGGACAAGATTTTATTGATGAGGCAACCAAATTATTTGGAAGTAGTAATCATCGTGATTTTACTTATTCTTTG
AATGAAATTCAACTAGGTATGCCATTAGGTACAGCTAGGAAAGTTATTTGTGTCGGGAAGAATTATGCAGAGCATGTCGC
TGAAATGAAAAGTGAAATCCCAGAATTTCCAGTACTATTTGCTAAATTTGATAATGCGATTATCGGCCCAGAAGAGGAGA
TACATTATTCATCATTAACTGAAAAATTGGATTATGAAGTTGAATTAACGATTGTTATTGGGAGAGAAGCTTCCCATGTA
TTCGAAGAAGAAGCATTGGATTATGTAGCTGGCTATACAATTGGAAATGACACTTCTGCTCGAGATTTACAGAAGCGTAC
ACCTCAATGGTTACAAGGTAAAAGCTTGGATCATACGACGCCAATTGGACCGTGGGTTGTAACAAAAGATGAAATTGTAG
ATCCTGGTAATTTGACTATCGCATCCTATGTTAATAATGAAAAACGTCAATACTCCAATACCAAACATTTAATTTTTTCT
GTGCCATACCTCGTGTCATTTATTTCAAATCTAATTACTTTGAAACCAGGAGATATAATTATGACAGGTACTCCTGATGG
GGTAGGATTTGCAATGGATCCTCCAGGATATGTAAAAGATAAGGATAAAGTTAAGTTAGAAATTGAAGGAATAGGTATAA
TGGAAAACATGGTTAAAAAAGTTTAA

Upstream 100 bases:

>100_bases
TATAAAAAGCAGGAAACTGTATCTTCTACAAAGTCGGCAAGTTAAGTCGATTTATAGGAATCATTGATTTATACTATGAA
GTAGAATGGGGGAATGGGGA

Downstream 100 bases:

>100_bases
TAGGTGAGCAGCTTCATGTAAAAAGAACTGCAATGCTAACTTTAATATGATGGTATCGGCAATAATGAAATGGGATTAGT
TTTTAAATATTATATAACTA

Product: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKLVSYRKKESDSSFRMGFITDNEEVVDVHLASQHAIQAGNTTIELPFQPELFYQKGQDFIDEATKLFGSSNHRDFTYSL
NEIQLGMPLGTARKVICVGKNYAEHVAEMKSEIPEFPVLFAKFDNAIIGPEEEIHYSSLTEKLDYEVELTIVIGREASHV
FEEEALDYVAGYTIGNDTSARDLQKRTPQWLQGKSLDHTTPIGPWVVTKDEIVDPGNLTIASYVNNEKRQYSNTKHLIFS
VPYLVSFISNLITLKPGDIIMTGTPDGVGFAMDPPGYVKDKDKVKLEIEGIGIMENMVKKV

Sequences:

>Translated_301_residues
MKLVSYRKKESDSSFRMGFITDNEEVVDVHLASQHAIQAGNTTIELPFQPELFYQKGQDFIDEATKLFGSSNHRDFTYSL
NEIQLGMPLGTARKVICVGKNYAEHVAEMKSEIPEFPVLFAKFDNAIIGPEEEIHYSSLTEKLDYEVELTIVIGREASHV
FEEEALDYVAGYTIGNDTSARDLQKRTPQWLQGKSLDHTTPIGPWVVTKDEIVDPGNLTIASYVNNEKRQYSNTKHLIFS
VPYLVSFISNLITLKPGDIIMTGTPDGVGFAMDPPGYVKDKDKVKLEIEGIGIMENMVKKV
>Mature_301_residues
MKLVSYRKKESDSSFRMGFITDNEEVVDVHLASQHAIQAGNTTIELPFQPELFYQKGQDFIDEATKLFGSSNHRDFTYSL
NEIQLGMPLGTARKVICVGKNYAEHVAEMKSEIPEFPVLFAKFDNAIIGPEEEIHYSSLTEKLDYEVELTIVIGREASHV
FEEEALDYVAGYTIGNDTSARDLQKRTPQWLQGKSLDHTTPIGPWVVTKDEIVDPGNLTIASYVNNEKRQYSNTKHLIFS
VPYLVSFISNLITLKPGDIIMTGTPDGVGFAMDPPGYVKDKDKVKLEIEGIGIMENMVKKV

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=220, Percent_Identity=41.3636363636364, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI40786394, Length=281, Percent_Identity=37.0106761565836, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI13654274, Length=213, Percent_Identity=39.4366197183099, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI66348062, Length=204, Percent_Identity=39.7058823529412, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI215422413, Length=204, Percent_Identity=39.7058823529412, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1787428, Length=180, Percent_Identity=36.6666666666667, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17557057, Length=181, Percent_Identity=37.0165745856354, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324161, Length=235, Percent_Identity=28.936170212766, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28572127, Length=220, Percent_Identity=41.8181818181818, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24663695, Length=220, Percent_Identity=35, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28571789, Length=183, Percent_Identity=32.2404371584699, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 33819; Mature: 33819

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVSYRKKESDSSFRMGFITDNEEVVDVHLASQHAIQAGNTTIELPFQPELFYQKGQDF
CCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCHHEECCCEEEECCCCCHHHHHCCHHH
IDEATKLFGSSNHRDFTYSLNEIQLGMPLGTARKVICVGKNYAEHVAEMKSEIPEFPVLF
HHHHHHHHCCCCCCEEEEEECEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEE
AKFDNAIIGPEEEIHYSSLTEKLDYEVELTIVIGREASHVFEEEALDYVAGYTIGNDTSA
EECCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHCEEECCCCCH
RDLQKRTPQWLQGKSLDHTTPIGPWVVTKDEIVDPGNLTIASYVNNEKRQYSNTKHLIFS
HHHHHCCCHHHCCCCCCCCCCCCCEEEEHHHCCCCCCEEEEEECCCHHHHHCCCCEEEEE
VPYLVSFISNLITLKPGDIIMTGTPDGVGFAMDPPGYVKDKDKVKLEIEGIGIMENMVKK
HHHHHHHHHHHEEECCCCEEEECCCCCCCEEECCCCCCCCCCCEEEEEECCCHHHHHHHC
V
C
>Mature Secondary Structure
MKLVSYRKKESDSSFRMGFITDNEEVVDVHLASQHAIQAGNTTIELPFQPELFYQKGQDF
CCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCHHEECCCEEEECCCCCHHHHHCCHHH
IDEATKLFGSSNHRDFTYSLNEIQLGMPLGTARKVICVGKNYAEHVAEMKSEIPEFPVLF
HHHHHHHHCCCCCCEEEEEECEEEECCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEE
AKFDNAIIGPEEEIHYSSLTEKLDYEVELTIVIGREASHVFEEEALDYVAGYTIGNDTSA
EECCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHCEEECCCCCH
RDLQKRTPQWLQGKSLDHTTPIGPWVVTKDEIVDPGNLTIASYVNNEKRQYSNTKHLIFS
HHHHHCCCHHHCCCCCCCCCCCCCEEEEHHHCCCCCCEEEEEECCCHHHHHCCCCEEEEE
VPYLVSFISNLITLKPGDIIMTGTPDGVGFAMDPPGYVKDKDKVKLEIEGIGIMENMVKK
HHHHHHHHHHHEEECCCCEEEECCCCCCCEEECCCCCCCCCCCEEEEEECCCHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]