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The map label for this gene is mro [H]

Identifier: 23099663

GI number: 23099663

Start: 2243237

End: 2244271

Strand: Reverse

Name: mro [H]

Synonym: OB2208

Alternate gene names: 23099663

Gene position: 2244271-2243237 (Counterclockwise)

Preceding gene: 23099664

Following gene: 23099662

Centisome position: 61.82

GC content: 34.3

Gene sequence:

>1035_bases
ATGCAAATTCGTAGAGAAAATGTACATAATAATTGGAAACAATTTACATTAATTAACGATCGTGACATGGAAGTTTCTAT
ATTAAATTATGGAGGGATTATTACACGTATTATAACGCCAGATAGGAATGAACAGAAAAGAAATATTGTTGCACGATATA
AAAATTTAGATGATTATATCGAGAATCCATTATATCTTGGGGCGATAATTGGTAGAGTGGCAGGAAGAATTCAAAATGGT
AGTTTTTCCATAGGAGATAAAGAAATTCAATTACAAGCCAACGAAGGTTATCATGTGCTTCATGGTGGGAAGAGTGGATT
TCATCAGATCTTATGGGATGTAACAACAATTGAAAAACCGGACTATGTAGGAATTCGACTAACTTATACAAGTAAAGAGA
ATGAAAGTGATTTTCCAGGTAATGTGAATGTAGCTATTACGTACTATTTGGATAATCAAAATGAATTAACAATTGATTAT
AATGCAATAAGTGATAAGCAGACTCCGATTACATTGACGAATCACTCGTATTTTAATTTAAGTGGAGATCTAGAACAAAC
CATACATGAACATGAGATGACATTGGACAGTGATCAGTTTCTGGAACTAGATGAAGAATTGATTCCAACAGGAGAAATGG
TAGATGTAGATATGACACCATTTGATTTTCGAAGCGGACGTTGTCTGAGTATTGGCTTAAACAACGATTTCTATCAGAAT
AAGATTGTTGGATCGGGATATGATCACTTTTTTCTATTTAATCATGAAAAAAAACATGTCGTGAATATGGTTGAACCTAG
AAGTGGCAGGCAGCTCTTTATTTCTACTAATCAACCAGGGATGGTCATGTATACATCAAATTCGGTAGATTCTAGTCAGC
AATTTTATGAAGGCGAGGCAAAGAAATACATTGCCGTGTGTTTTGAAACTCAGGGGAGCCCTGCATCTTTACACCATGAT
AACCTTGAAACAATTCTATTAGAAGCGAATCAGCCTTATCAAAAAACAACAACATTCCAGTTTGGGGTAATTTAG

Upstream 100 bases:

>100_bases
TAGAATGATAAGTGTTACTCGAAATAGATAAGTCTTTTCAAATATATTTTTAAAATCAATCTGTAAATTATAAAAGATTA
CTAGTTTGGAGTGATAAAAT

Downstream 100 bases:

>100_bases
TTCAGTAAGAGTAATAATAGTTTTTTTAATAGCATAGTGTATAGGATAAGAATTATATTTGCTTAGATAGAGGCTGGGAC
ATAACAAAAAATTCTGGTCA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MQIRRENVHNNWKQFTLINDRDMEVSILNYGGIITRIITPDRNEQKRNIVARYKNLDDYIENPLYLGAIIGRVAGRIQNG
SFSIGDKEIQLQANEGYHVLHGGKSGFHQILWDVTTIEKPDYVGIRLTYTSKENESDFPGNVNVAITYYLDNQNELTIDY
NAISDKQTPITLTNHSYFNLSGDLEQTIHEHEMTLDSDQFLELDEELIPTGEMVDVDMTPFDFRSGRCLSIGLNNDFYQN
KIVGSGYDHFFLFNHEKKHVVNMVEPRSGRQLFISTNQPGMVMYTSNSVDSSQQFYEGEAKKYIAVCFETQGSPASLHHD
NLETILLEANQPYQKTTTFQFGVI

Sequences:

>Translated_344_residues
MQIRRENVHNNWKQFTLINDRDMEVSILNYGGIITRIITPDRNEQKRNIVARYKNLDDYIENPLYLGAIIGRVAGRIQNG
SFSIGDKEIQLQANEGYHVLHGGKSGFHQILWDVTTIEKPDYVGIRLTYTSKENESDFPGNVNVAITYYLDNQNELTIDY
NAISDKQTPITLTNHSYFNLSGDLEQTIHEHEMTLDSDQFLELDEELIPTGEMVDVDMTPFDFRSGRCLSIGLNNDFYQN
KIVGSGYDHFFLFNHEKKHVVNMVEPRSGRQLFISTNQPGMVMYTSNSVDSSQQFYEGEAKKYIAVCFETQGSPASLHHD
NLETILLEANQPYQKTTTFQFGVI
>Mature_344_residues
MQIRRENVHNNWKQFTLINDRDMEVSILNYGGIITRIITPDRNEQKRNIVARYKNLDDYIENPLYLGAIIGRVAGRIQNG
SFSIGDKEIQLQANEGYHVLHGGKSGFHQILWDVTTIEKPDYVGIRLTYTSKENESDFPGNVNVAITYYLDNQNELTIDY
NAISDKQTPITLTNHSYFNLSGDLEQTIHEHEMTLDSDQFLELDEELIPTGEMVDVDMTPFDFRSGRCLSIGLNNDFYQN
KIVGSGYDHFFLFNHEKKHVVNMVEPRSGRQLFISTNQPGMVMYTSNSVDSSQQFYEGEAKKYIAVCFETQGSPASLHHD
NLETILLEANQPYQKTTTFQFGVI

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=334, Percent_Identity=36.5269461077844, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI1786971, Length=335, Percent_Identity=26.865671641791, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17557428, Length=338, Percent_Identity=28.4023668639053, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533334, Length=338, Percent_Identity=28.4023668639053, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319493, Length=271, Percent_Identity=30.2583025830258, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322004, Length=359, Percent_Identity=26.4623955431755, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324399, Length=231, Percent_Identity=29.004329004329, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24668278, Length=342, Percent_Identity=31.5789473684211, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24659048, Length=347, Percent_Identity=34.2939481268012, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24583720, Length=352, Percent_Identity=32.1022727272727, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24668282, Length=344, Percent_Identity=30.8139534883721, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24641876, Length=349, Percent_Identity=25.5014326647564, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39463; Mature: 39463

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRRENVHNNWKQFTLINDRDMEVSILNYGGIITRIITPDRNEQKRNIVARYKNLDDYI
CCCCCCCCCCCCEEEEEECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCHHHH
ENPLYLGAIIGRVAGRIQNGSFSIGDKEIQLQANEGYHVLHGGKSGFHQILWDVTTIEKP
CCCCHHHHHHHHHHHEECCCCEEECCEEEEEEECCCEEEEECCCCCHHHHHEEEEECCCC
DYVGIRLTYTSKENESDFPGNVNVAITYYLDNQNELTIDYNAISDKQTPITLTNHSYFNL
CEEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCEEEECCEEEEE
SGDLEQTIHEHEMTLDSDQFLELDEELIPTGEMVDVDMTPFDFRSGRCLSIGLNNDFYQN
CCCHHHHHHHHHCCCCCCHHHHCCHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCHHC
KIVGSGYDHFFLFNHEKKHVVNMVEPRSGRQLFISTNQPGMVMYTSNSVDSSQQFYEGEA
EEECCCCCEEEEEECCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHCCCC
KKYIAVCFETQGSPASLHHDNLETILLEANQPYQKTTTFQFGVI
CEEEEEEEECCCCCCEEECCCEEEEEEECCCCCCCEEEEEEECC
>Mature Secondary Structure
MQIRRENVHNNWKQFTLINDRDMEVSILNYGGIITRIITPDRNEQKRNIVARYKNLDDYI
CCCCCCCCCCCCEEEEEECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCHHHH
ENPLYLGAIIGRVAGRIQNGSFSIGDKEIQLQANEGYHVLHGGKSGFHQILWDVTTIEKP
CCCCHHHHHHHHHHHEECCCCEEECCEEEEEEECCCEEEEECCCCCHHHHHEEEEECCCC
DYVGIRLTYTSKENESDFPGNVNVAITYYLDNQNELTIDYNAISDKQTPITLTNHSYFNL
CEEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCCCEEEECCEEEEE
SGDLEQTIHEHEMTLDSDQFLELDEELIPTGEMVDVDMTPFDFRSGRCLSIGLNNDFYQN
CCCHHHHHHHHHCCCCCCHHHHCCHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCHHC
KIVGSGYDHFFLFNHEKKHVVNMVEPRSGRQLFISTNQPGMVMYTSNSVDSSQQFYEGEA
EEECCCCCEEEEEECCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHCCCC
KKYIAVCFETQGSPASLHHDNLETILLEANQPYQKTTTFQFGVI
CEEEEEEEECCCCCCEEECCCEEEEEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]