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The map label for this gene is tpx

Identifier: 23099648

GI number: 23099648

Start: 2228346

End: 2228840

Strand: Reverse

Name: tpx

Synonym: OB2193

Alternate gene names: 23099648

Gene position: 2228840-2228346 (Counterclockwise)

Preceding gene: 23099649

Following gene: 23099647

Centisome position: 61.39

GC content: 34.55

Gene sequence:

>495_bases
ATGTCAAATGTAACCTTTAAAAACGATCCAGTAACTTTACTAGGTGCAGAAAAGAAAGTCGGAGATAGTGCACCAGATTT
TACGGTTCTAGCAAATGATTTATCAAAAAAACACTTAAGTGACTACAAAGGAAAAGTAAAAGTTATTAGTGTTGTTCCAT
CAATTGATACAGGTGTTTGTTCTGAGCAGACTCGTCGTTTTAATCAGGAAGCAACCAACTTAGAAAATGTTCAAATACTT
ACTATCAGTATGGATCTTCCTTTTGCTCAAAAACGCTGGTGTGCTGCAAATGGTATAGATAGAGTGGATACTTTATCTGA
TCATCGCGAAGCAGATTTTGGTCAGAAATATGGCGTGATTATTGAAGAGTTACGTTTATTATCTAGAGCTGTATTTGTCG
TTGATGAGAATGATAAGATAACTTATGTTGAATACTTATCAGAGGTCAGTAACCATCCTGATTATGAAGCTGTACTATCA
CACTTAAACAAATAA

Upstream 100 bases:

>100_bases
AAAGCGAATAGATCTCCTTAAATGATGTCTAACATTGGACATGTATTTCGATAGGCTTCATAATAAAATGTAGACACAAG
ATGATTGGGAGAGATAATTT

Downstream 100 bases:

>100_bases
CTTTCAAGGATAGCCATCCCGGAAATTTGGGATGGCTTTTTTGAATAAACCAATCTAATTTATAATTGTGTAATTCGATA
AAAAAATCACCTTTTATTTG

Product: thioredoxin peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSNVTFKNDPVTLLGAEKKVGDSAPDFTVLANDLSKKHLSDYKGKVKVISVVPSIDTGVCSEQTRRFNQEATNLENVQIL
TISMDLPFAQKRWCAANGIDRVDTLSDHREADFGQKYGVIIEELRLLSRAVFVVDENDKITYVEYLSEVSNHPDYEAVLS
HLNK

Sequences:

>Translated_164_residues
MSNVTFKNDPVTLLGAEKKVGDSAPDFTVLANDLSKKHLSDYKGKVKVISVVPSIDTGVCSEQTRRFNQEATNLENVQIL
TISMDLPFAQKRWCAANGIDRVDTLSDHREADFGQKYGVIIEELRLLSRAVFVVDENDKITYVEYLSEVSNHPDYEAVLS
HLNK
>Mature_163_residues
SNVTFKNDPVTLLGAEKKVGDSAPDFTVLANDLSKKHLSDYKGKVKVISVVPSIDTGVCSEQTRRFNQEATNLENVQILT
ISMDLPFAQKRWCAANGIDRVDTLSDHREADFGQKYGVIIEELRLLSRAVFVVDENDKITYVEYLSEVSNHPDYEAVLSH
LNK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2)

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1787584, Length=162, Percent_Identity=46.9135802469136, Blast_Score=154, Evalue=4e-39,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPX_OCEIH (Q8EPB7)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693114.1
- ProteinModelPortal:   Q8EPB7
- SMR:   Q8EPB7
- GeneID:   1017603
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2193
- NMPDR:   fig|221109.1.peg.2191
- HOGENOM:   HBG493509
- OMA:   VRKFNAQ
- BioCyc:   OIHE221109:OB2193-MONOMER
- HAMAP:   MF_00269
- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10681:SF3

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18390; Mature: 18259

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS51352 THIOREDOXIN_2; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVTFKNDPVTLLGAEKKVGDSAPDFTVLANDLSKKHLSDYKGKVKVISVVPSIDTGVC
CCCCCCCCCCEEEEECCHHCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
SEQTRRFNQEATNLENVQILTISMDLPFAQKRWCAANGIDRVDTLSDHREADFGQKYGVI
CHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHH
IEELRLLSRAVFVVDENDKITYVEYLSEVSNHPDYEAVLSHLNK
HHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
SNVTFKNDPVTLLGAEKKVGDSAPDFTVLANDLSKKHLSDYKGKVKVISVVPSIDTGVC
CCCCCCCCCEEEEECCHHCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
SEQTRRFNQEATNLENVQILTISMDLPFAQKRWCAANGIDRVDTLSDHREADFGQKYGVI
CHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHH
IEELRLLSRAVFVVDENDKITYVEYLSEVSNHPDYEAVLSHLNK
HHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376