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The map label for this gene is trxA [H]

Identifier: 23099572

GI number: 23099572

Start: 2151240

End: 2151554

Strand: Reverse

Name: trxA [H]

Synonym: OB2117

Alternate gene names: 23099572

Gene position: 2151554-2151240 (Counterclockwise)

Preceding gene: 23099573

Following gene: 23099571

Centisome position: 59.26

GC content: 35.87

Gene sequence:

>315_bases
ATGGCTATTAAGCATGTAACTGATCAAAACTTTACAGAAGAAACTTCAAAAGGTCTTGTATTGGCTGATTTTTGGGCACC
GTGGTGTGGACCTTGTAAAATGATTGCACCAGTACTAGAAGAAATTGATGGTGAGATGGAAGAAAAAGTACAAATTGTTA
AATTAGATGTAGATGAAAATCAAGAAACTGCAGGTAAATTTGGAGTAATGAGCATCCCAACATTACTATTATTCAAAGAT
GGGGATGTAGTGGATCAAGTTATTGGATTCCAGCCGAAAGAAGCATTAGAGGATCTTATAAACAAACACGCGTAA

Upstream 100 bases:

>100_bases
AGATAAGCAAACTATTAGGAAGTATATGCCATGGGTGATATACTCATAATAAGCTTTAGATGAAGCTTGATGAATTTGTT
TTTTAAGGAGGTAACAAATA

Downstream 100 bases:

>100_bases
GAGAATTTACTTGGTGTTGTAACTGAATACCTGTATAATTATAAGAAATAGAGAAAAATCCCTTGTCTGTCATTATTGCT
GATAAGGGATTTTCTAATTA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIKHVTDQNFTEETSKGLVLADFWAPWCGPCKMIAPVLEEIDGEMEEKVQIVKLDVDENQETAGKFGVMSIPTLLLFKD
GDVVDQVIGFQPKEALEDLINKHA

Sequences:

>Translated_104_residues
MAIKHVTDQNFTEETSKGLVLADFWAPWCGPCKMIAPVLEEIDGEMEEKVQIVKLDVDENQETAGKFGVMSIPTLLLFKD
GDVVDQVIGFQPKEALEDLINKHA
>Mature_103_residues
AIKHVTDQNFTEETSKGLVLADFWAPWCGPCKMIAPVLEEIDGEMEEKVQIVKLDVDENQETAGKFGVMSIPTLLLFKDG
DVVDQVIGFQPKEALEDLINKHA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=87, Percent_Identity=39.0804597701149, Blast_Score=75, Evalue=9e-15,
Organism=Homo sapiens, GI21361657, Length=81, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI42794771, Length=97, Percent_Identity=36.0824742268041, Blast_Score=63, Evalue=6e-11,
Organism=Homo sapiens, GI224493972, Length=97, Percent_Identity=36.0824742268041, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=46.6019417475728, Blast_Score=102, Evalue=4e-24,
Organism=Escherichia coli, GI1788936, Length=83, Percent_Identity=43.3734939759036, Blast_Score=90, Evalue=3e-20,
Organism=Escherichia coli, GI87081747, Length=94, Percent_Identity=35.1063829787234, Blast_Score=65, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=100, Percent_Identity=41, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=36.1702127659575, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=97, Percent_Identity=34.020618556701, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=79, Percent_Identity=40.5063291139241, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=43.2098765432099, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=71, Percent_Identity=36.6197183098592, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=81, Percent_Identity=32.0987654320988, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=47.6744186046512, Blast_Score=76, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=41.1111111111111, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=89, Percent_Identity=39.3258426966292, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=83, Percent_Identity=39.7590361445783, Blast_Score=78, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=40.6976744186046, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17648013, Length=96, Percent_Identity=39.5833333333333, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583090, Length=96, Percent_Identity=39.5833333333333, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664269, Length=86, Percent_Identity=36.046511627907, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24658597, Length=93, Percent_Identity=35.4838709677419, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11588; Mature: 11457

Theoretical pI: Translated: 4.12; Mature: 4.12

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKHVTDQNFTEETSKGLVLADFWAPWCGPCKMIAPVLEEIDGEMEEKVQIVKLDVDEN
CCCCCCCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHCCEEEEEEECCCC
QETAGKFGVMSIPTLLLFKDGDVVDQVIGFQPKEALEDLINKHA
CCCCCCCCHHCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AIKHVTDQNFTEETSKGLVLADFWAPWCGPCKMIAPVLEEIDGEMEEKVQIVKLDVDEN
CCCCCCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHCCEEEEEEECCCC
QETAGKFGVMSIPTLLLFKDGDVVDQVIGFQPKEALEDLINKHA
CCCCCCCCHHCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]