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The map label for this gene is uvrC

Identifier: 23099571

GI number: 23099571

Start: 2149247

End: 2151037

Strand: Reverse

Name: uvrC

Synonym: OB2116

Alternate gene names: 23099571

Gene position: 2151037-2149247 (Counterclockwise)

Preceding gene: 23099572

Following gene: 23099569

Centisome position: 59.25

GC content: 34.06

Gene sequence:

>1791_bases
ATGAATGAAAATATAGAGAAAAAACTGTCTATATTGCCACAACAACCAGGTTGTTATTTAATGAAAGATAAAAATGGGAC
TGTTATTTATGTTGGGAAATCAAAAAAATTAAGAAATAGAGTAAGATCGTATTTTAGAGGTGCAAATGATAGGAAAACAC
AACGATTAGTTCAAGAAATTAGAGATTTTGAGTACATGGTTACTTCTTCAGAGATTGAAGCATTGATTTTGGAAATGAAT
TTAATTAAAAAATATGATCCTAGGTATAATGTCATGTTAAAGGATGATAAATCGTATCCTTATTTGAAAATCACCTCAGA
AAGGCATCCTCGTTTAATTGTTACTCGACGATTAAAAAAAGATAAGGGTAAGTACTTTGGACCTTATCCCAACGTAATAG
CCGCTCGGGAAACAAAAAAACTTCTAGATCGAATGTATCCTTTGCGAAAATGTAATAACCCCTCGGGGAGGCCCTGTCTT
TATTATCATATGGGACAGTGCAAAGCTTGTGCGGAAAATCCACCTTCCGTAAAAGAATATCAAGAAATAGTTCAAGAGAT
TAGCTCTTTTTTGCAGGGTGGATTTAAAGATATACGAAAAAATTTAGCAGGGGAAATGCAAAAGGCAAGCGAAGCGTTAA
ATTTTGAACGAGCGAAAGAGATAAGGGACACAATACAACATATCGATGCTACAATGGAACAGCAAAAAATGACATTGACT
GATCAAATGGATAGGGATATCTTTGGTTATAGCTATGATAAGGGATGGATGTGTGTCCAAGTATTCTTCATACGACAAGG
GAAATTAATTGAAAGAGATACCAGTGTTTTTCCATTTTTTGATAGTCCTGAAGAAACAATAGTCAGCTTTATCGGAAGAT
TTTATTTACATGAAAATCATTTGAAGCCAAAACAAGTATTAGTTCCGGTTGGTATCGACAACGAATTATTAGCTAAAGTG
TTAGAGATACAGGTGCATATACCATTAAGAGGAAGAAAAAAAGAACTGGTACAATTAGCTGTTAAAAATGCAGAGATTTC
TTTAAATGAAAAATTTCAATTAATTGAAAAAGATGAAGAACGAACAATTCAAGCTATAGAAGATTTAGGTGAACAATTAA
ATATAGAGACACCACATCGAATAGAAGCTTTTGATAACTCGAATATACAAGGTACTGATCCAGTCTCTGCAATGATTGTT
TTTGAAGACGGGAAGCCAAATAAAAAAGAATATCGTAAATATAAGATTCGGGATGTAAAAGGCCCCGATGATTATGATAC
GATGCGGGAAGTGGTTCGAAGGCGATATTCGCGTGTCTTGAAAGAAAATTTACCATTACCAGATTTGATTATCGTTGACG
GGGGAAAAGGTCAAATGTCCGCAGCGTTAGAAGTTTTAGAAGATGAGTTAGGTTTAGATATACCATTAGCAGGACTAGCC
AAAGATGATCGTCATAAAACAAGTGAACTGTTATATGGAATGCCACCTATAGTTGTTCCATTAGAAAGACAATCTCAAGC
TTTTTACCTTGTACAGCGAATTCAAGACGAAGTACATCGATTTGCAATTACATTCCATCGCCAATTAAGAGGGAAGAGCT
TATTTCAGTCTGAATTAGATAAGATTCCGGGTGTTGGTGAAAAGAGAAGAAAACTGTTACTTTCACACTTTAAATCGATT
AATCAAATAAAAAAAGCATCTATTGAAGATATGAGGAAATTGGGGATTCCAAGTAATATAGCTGAATTAGTATTGAATCA
TTTAAACTCACCAAATGATGATGAAACGTAA

Upstream 100 bases:

>100_bases
CAAATAAACATACTGATGAGCAATGTACAAACTGTACTAACTCACATTTGCAGAAAGTAATTATTATCGTTCTTATCGAT
GAATAAAGGATTTGACGCTT

Downstream 100 bases:

>100_bases
ATCATGATTATTTGAGCCAATTTCATACGTGCTAGATTTAATTTAAAAAACCACAAGAATTTCTAGATCTTGTGGCTTTT
TATTTAATATGTAGTTTACT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MNENIEKKLSILPQQPGCYLMKDKNGTVIYVGKSKKLRNRVRSYFRGANDRKTQRLVQEIRDFEYMVTSSEIEALILEMN
LIKKYDPRYNVMLKDDKSYPYLKITSERHPRLIVTRRLKKDKGKYFGPYPNVIAARETKKLLDRMYPLRKCNNPSGRPCL
YYHMGQCKACAENPPSVKEYQEIVQEISSFLQGGFKDIRKNLAGEMQKASEALNFERAKEIRDTIQHIDATMEQQKMTLT
DQMDRDIFGYSYDKGWMCVQVFFIRQGKLIERDTSVFPFFDSPEETIVSFIGRFYLHENHLKPKQVLVPVGIDNELLAKV
LEIQVHIPLRGRKKELVQLAVKNAEISLNEKFQLIEKDEERTIQAIEDLGEQLNIETPHRIEAFDNSNIQGTDPVSAMIV
FEDGKPNKKEYRKYKIRDVKGPDDYDTMREVVRRRYSRVLKENLPLPDLIIVDGGKGQMSAALEVLEDELGLDIPLAGLA
KDDRHKTSELLYGMPPIVVPLERQSQAFYLVQRIQDEVHRFAITFHRQLRGKSLFQSELDKIPGVGEKRRKLLLSHFKSI
NQIKKASIEDMRKLGIPSNIAELVLNHLNSPNDDET

Sequences:

>Translated_596_residues
MNENIEKKLSILPQQPGCYLMKDKNGTVIYVGKSKKLRNRVRSYFRGANDRKTQRLVQEIRDFEYMVTSSEIEALILEMN
LIKKYDPRYNVMLKDDKSYPYLKITSERHPRLIVTRRLKKDKGKYFGPYPNVIAARETKKLLDRMYPLRKCNNPSGRPCL
YYHMGQCKACAENPPSVKEYQEIVQEISSFLQGGFKDIRKNLAGEMQKASEALNFERAKEIRDTIQHIDATMEQQKMTLT
DQMDRDIFGYSYDKGWMCVQVFFIRQGKLIERDTSVFPFFDSPEETIVSFIGRFYLHENHLKPKQVLVPVGIDNELLAKV
LEIQVHIPLRGRKKELVQLAVKNAEISLNEKFQLIEKDEERTIQAIEDLGEQLNIETPHRIEAFDNSNIQGTDPVSAMIV
FEDGKPNKKEYRKYKIRDVKGPDDYDTMREVVRRRYSRVLKENLPLPDLIIVDGGKGQMSAALEVLEDELGLDIPLAGLA
KDDRHKTSELLYGMPPIVVPLERQSQAFYLVQRIQDEVHRFAITFHRQLRGKSLFQSELDKIPGVGEKRRKLLLSHFKSI
NQIKKASIEDMRKLGIPSNIAELVLNHLNSPNDDET
>Mature_596_residues
MNENIEKKLSILPQQPGCYLMKDKNGTVIYVGKSKKLRNRVRSYFRGANDRKTQRLVQEIRDFEYMVTSSEIEALILEMN
LIKKYDPRYNVMLKDDKSYPYLKITSERHPRLIVTRRLKKDKGKYFGPYPNVIAARETKKLLDRMYPLRKCNNPSGRPCL
YYHMGQCKACAENPPSVKEYQEIVQEISSFLQGGFKDIRKNLAGEMQKASEALNFERAKEIRDTIQHIDATMEQQKMTLT
DQMDRDIFGYSYDKGWMCVQVFFIRQGKLIERDTSVFPFFDSPEETIVSFIGRFYLHENHLKPKQVLVPVGIDNELLAKV
LEIQVHIPLRGRKKELVQLAVKNAEISLNEKFQLIEKDEERTIQAIEDLGEQLNIETPHRIEAFDNSNIQGTDPVSAMIV
FEDGKPNKKEYRKYKIRDVKGPDDYDTMREVVRRRYSRVLKENLPLPDLIIVDGGKGQMSAALEVLEDELGLDIPLAGLA
KDDRHKTSELLYGMPPIVVPLERQSQAFYLVQRIQDEVHRFAITFHRQLRGKSLFQSELDKIPGVGEKRRKLLLSHFKSI
NQIKKASIEDMRKLGIPSNIAELVLNHLNSPNDDET

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=619, Percent_Identity=37.8029079159935, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_OCEIH (Q8CXB4)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693037.1
- ProteinModelPortal:   Q8CXB4
- GeneID:   1015642
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2116
- NMPDR:   fig|221109.1.peg.2114
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   OIHE221109:OB2116-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69199; Mature: 69199

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNENIEKKLSILPQQPGCYLMKDKNGTVIYVGKSKKLRNRVRSYFRGANDRKTQRLVQEI
CCCCHHHHHHHCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHH
RDFEYMVTSSEIEALILEMNLIKKYDPRYNVMLKDDKSYPYLKITSERHPRLIVTRRLKK
HHHHHHEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCEEHHHHHHHH
DKGKYFGPYPNVIAARETKKLLDRMYPLRKCNNPSGRPCLYYHMGQCKACAENPPSVKEY
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCCCCHHHH
QEIVQEISSFLQGGFKDIRKNLAGEMQKASEALNFERAKEIRDTIQHIDATMEQQKMTLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DQMDRDIFGYSYDKGWMCVQVFFIRQGKLIERDTSVFPFFDSPEETIVSFIGRFYLHENH
HHHCCCCCCCCCCCCCEEEEEEEHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LKPKQVLVPVGIDNELLAKVLEIQVHIPLRGRKKELVQLAVKNAEISLNEKFQLIEKDEE
CCCCCEEEECCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCEEECCHHHHHCCCHH
RTIQAIEDLGEQLNIETPHRIEAFDNSNIQGTDPVSAMIVFEDGKPNKKEYRKYKIRDVK
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHEEECC
GPDDYDTMREVVRRRYSRVLKENLPLPDLIIVDGGKGQMSAALEVLEDELGLDIPLAGLA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
KDDRHKTSELLYGMPPIVVPLERQSQAFYLVQRIQDEVHRFAITFHRQLRGKSLFQSELD
CCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KIPGVGEKRRKLLLSHFKSINQIKKASIEDMRKLGIPSNIAELVLNHLNSPNDDET
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNENIEKKLSILPQQPGCYLMKDKNGTVIYVGKSKKLRNRVRSYFRGANDRKTQRLVQEI
CCCCHHHHHHHCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHH
RDFEYMVTSSEIEALILEMNLIKKYDPRYNVMLKDDKSYPYLKITSERHPRLIVTRRLKK
HHHHHHEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCEEHHHHHHHH
DKGKYFGPYPNVIAARETKKLLDRMYPLRKCNNPSGRPCLYYHMGQCKACAENPPSVKEY
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCCCCHHHH
QEIVQEISSFLQGGFKDIRKNLAGEMQKASEALNFERAKEIRDTIQHIDATMEQQKMTLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DQMDRDIFGYSYDKGWMCVQVFFIRQGKLIERDTSVFPFFDSPEETIVSFIGRFYLHENH
HHHCCCCCCCCCCCCCEEEEEEEHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LKPKQVLVPVGIDNELLAKVLEIQVHIPLRGRKKELVQLAVKNAEISLNEKFQLIEKDEE
CCCCCEEEECCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCEEECCHHHHHCCCHH
RTIQAIEDLGEQLNIETPHRIEAFDNSNIQGTDPVSAMIVFEDGKPNKKEYRKYKIRDVK
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHEEECC
GPDDYDTMREVVRRRYSRVLKENLPLPDLIIVDGGKGQMSAALEVLEDELGLDIPLAGLA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
KDDRHKTSELLYGMPPIVVPLERQSQAFYLVQRIQDEVHRFAITFHRQLRGKSLFQSELD
CCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KIPGVGEKRRKLLLSHFKSINQIKKASIEDMRKLGIPSNIAELVLNHLNSPNDDET
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376