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The map label for this gene is ymxG [H]

Identifier: 23099061

GI number: 23099061

Start: 1644674

End: 1645894

Strand: Direct

Name: ymxG [H]

Synonym: OB1606

Alternate gene names: 23099061

Gene position: 1644674-1645894 (Clockwise)

Preceding gene: 23099060

Following gene: 23099062

Centisome position: 45.3

GC content: 33.82

Gene sequence:

>1221_bases
GTGATAGAAAGACATACATGTAATAACGGTCTACGAATTGTACATGAACAAATTCCAGCAGTACGTTCAGTAACCATTGG
TATATGGGTATTAACAGGATCTAGAAATGAATCCCAACAAAACAATGGAATCTCTCATTTCTTAGAGCATATGTTTTTTA
AGGGGACTGATAAAAGATCCGCACAAGATATTGCAGAAGAGTTTGATTCTATTGGAGGTCAAATTAATGCATTTACTTCC
AAAGAATATACGTGCTTTTACGCGAAAGTATTAGACACACATAAAGAATATGCCTTGGAAATATTAGCTGATATGTTTTT
TAACTCTACTTTTGATCCAGAAGAGATGGAAAGGGAGAAAAAGGTAGTATTAGAAGAGATAAAAATGTATGAAGATACGC
CAGATGACATAGTCCATGATTTATTAGCAAAAGCATCATATGGAACACATCCTTTAGGTTATTCTATATTAGGTACAGAA
GAGCAATTACTTTCTTTTGATTCAGCTCAATTGAATGATTATATTGAACATGCATATTCTCCAGATCGTGTAGTTATTTC
TGTAGCTGGAAATGTAGATTCTTCATTTATGAAGACAATTGAATCTTCATTTGGAAGCTATAAGGGTAAATCCAATTCAG
TTGAAATAATCAAACCTACATTTTTAGCTGAGTCAATTGATCGGCATAAAGATACAGAACAGGCACATCTATGTCTTGGT
TATCAAGGATTAGAGCAAGGTCATCCATTATTGTATAGTTTAACAATTATGAATAATGTATTAGGTGGGAGTATGAGTTC
TAGATTATTTCAAGATGTGCGTGAAAAGCAAGGTCTTGCATATGCGGTGTTTTCTTATCATTCCACATTTATTGATAGTG
GGTTACTCACGATATATGGTGGAACAGGAAAAGAACAATTATCGGTTCTTGAAGATACGATTCAATTGACGGTAGATACG
CTGATTCAAAATGGTTTAACAGATAAAGAACTTAGGAATAGTAAAGAGCAATTAAAAGGCGGTTTAATGCTAAGTCTAGA
AAGTACCAATAGCCGTATGTCACGTAATGGTAGAAATGAACTGCTATTAAAAAGACATCGTACACTAGATGAAATGATAC
AAGAAATTGATGCGGTAAGTCATGAGACTATTCAACAAGTCATTAATGAAGTATTCAAAGAAAAAGCAGCTCGTGCATTA
ATTGCACCAAAGGCGATCTAA

Upstream 100 bases:

>100_bases
GAAGAGATGATAACGATTATTAAAGAAAAAGGATATAAAATTGGTACAATTGAAGCACTATTAAGTGAAGATAGATAACC
GGATTTTAGGAGGAAATTTT

Downstream 100 bases:

>100_bases
ATAAAATTATTGATATAAAGTGAATCCGTTCCGTTATTGAGGAACGGATTTCTTTTGCATAAAGGAGTTTACCTTAAAAA
GAAAGATTTTATTTTAGATT

Product: processing proteinase

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MIERHTCNNGLRIVHEQIPAVRSVTIGIWVLTGSRNESQQNNGISHFLEHMFFKGTDKRSAQDIAEEFDSIGGQINAFTS
KEYTCFYAKVLDTHKEYALEILADMFFNSTFDPEEMEREKKVVLEEIKMYEDTPDDIVHDLLAKASYGTHPLGYSILGTE
EQLLSFDSAQLNDYIEHAYSPDRVVISVAGNVDSSFMKTIESSFGSYKGKSNSVEIIKPTFLAESIDRHKDTEQAHLCLG
YQGLEQGHPLLYSLTIMNNVLGGSMSSRLFQDVREKQGLAYAVFSYHSTFIDSGLLTIYGGTGKEQLSVLEDTIQLTVDT
LIQNGLTDKELRNSKEQLKGGLMLSLESTNSRMSRNGRNELLLKRHRTLDEMIQEIDAVSHETIQQVINEVFKEKAARAL
IAPKAI

Sequences:

>Translated_406_residues
MIERHTCNNGLRIVHEQIPAVRSVTIGIWVLTGSRNESQQNNGISHFLEHMFFKGTDKRSAQDIAEEFDSIGGQINAFTS
KEYTCFYAKVLDTHKEYALEILADMFFNSTFDPEEMEREKKVVLEEIKMYEDTPDDIVHDLLAKASYGTHPLGYSILGTE
EQLLSFDSAQLNDYIEHAYSPDRVVISVAGNVDSSFMKTIESSFGSYKGKSNSVEIIKPTFLAESIDRHKDTEQAHLCLG
YQGLEQGHPLLYSLTIMNNVLGGSMSSRLFQDVREKQGLAYAVFSYHSTFIDSGLLTIYGGTGKEQLSVLEDTIQLTVDT
LIQNGLTDKELRNSKEQLKGGLMLSLESTNSRMSRNGRNELLLKRHRTLDEMIQEIDAVSHETIQQVINEVFKEKAARAL
IAPKAI
>Mature_406_residues
MIERHTCNNGLRIVHEQIPAVRSVTIGIWVLTGSRNESQQNNGISHFLEHMFFKGTDKRSAQDIAEEFDSIGGQINAFTS
KEYTCFYAKVLDTHKEYALEILADMFFNSTFDPEEMEREKKVVLEEIKMYEDTPDDIVHDLLAKASYGTHPLGYSILGTE
EQLLSFDSAQLNDYIEHAYSPDRVVISVAGNVDSSFMKTIESSFGSYKGKSNSVEIIKPTFLAESIDRHKDTEQAHLCLG
YQGLEQGHPLLYSLTIMNNVLGGSMSSRLFQDVREKQGLAYAVFSYHSTFIDSGLLTIYGGTGKEQLSVLEDTIQLTVDT
LIQNGLTDKELRNSKEQLKGGLMLSLESTNSRMSRNGRNELLLKRHRTLDEMIQEIDAVSHETIQQVINEVFKEKAARAL
IAPKAI

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=418, Percent_Identity=31.1004784688995, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI46593007, Length=412, Percent_Identity=25.4854368932039, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24308013, Length=429, Percent_Identity=23.5431235431235, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI50592988, Length=375, Percent_Identity=20.2666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787770, Length=224, Percent_Identity=25, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71999683, Length=411, Percent_Identity=27.2506082725061, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17553678, Length=390, Percent_Identity=26.6666666666667, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17510601, Length=434, Percent_Identity=20.0460829493088, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323192, Length=410, Percent_Identity=30.9756097560976, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321813, Length=416, Percent_Identity=23.3173076923077, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319426, Length=400, Percent_Identity=23.25, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357875, Length=407, Percent_Identity=31.6953316953317, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24646943, Length=407, Percent_Identity=31.6953316953317, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921772, Length=443, Percent_Identity=24.3792325056433, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24665395, Length=385, Percent_Identity=22.5974025974026, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667786, Length=183, Percent_Identity=30.0546448087432, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 45710; Mature: 45710

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERHTCNNGLRIVHEQIPAVRSVTIGIWVLTGSRNESQQNNGISHFLEHMFFKGTDKRS
CCCCCCCCCCHHHHHHHCCHHHEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCH
AQDIAEEFDSIGGQINAFTSKEYTCFYAKVLDTHKEYALEILADMFFNSTFDPEEMEREK
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KVVLEEIKMYEDTPDDIVHDLLAKASYGTHPLGYSILGTEEQLLSFDSAQLNDYIEHAYS
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHCCC
PDRVVISVAGNVDSSFMKTIESSFGSYKGKSNSVEIIKPTFLAESIDRHKDTEQAHLCLG
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCHHHHEEC
YQGLEQGHPLLYSLTIMNNVLGGSMSSRLFQDVREKQGLAYAVFSYHSTFIDSGLLTIYG
HHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEC
GTGKEQLSVLEDTIQLTVDTLIQNGLTDKELRNSKEQLKGGLMLSLESTNSRMSRNGRNE
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHCCCEEEEEECCCHHHHCCCCHH
LLLKRHRTLDEMIQEIDAVSHETIQQVINEVFKEKAARALIAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIERHTCNNGLRIVHEQIPAVRSVTIGIWVLTGSRNESQQNNGISHFLEHMFFKGTDKRS
CCCCCCCCCCHHHHHHHCCHHHEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCH
AQDIAEEFDSIGGQINAFTSKEYTCFYAKVLDTHKEYALEILADMFFNSTFDPEEMEREK
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KVVLEEIKMYEDTPDDIVHDLLAKASYGTHPLGYSILGTEEQLLSFDSAQLNDYIEHAYS
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHCCHHHHHHHHHHCCC
PDRVVISVAGNVDSSFMKTIESSFGSYKGKSNSVEIIKPTFLAESIDRHKDTEQAHLCLG
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCHHHHEEC
YQGLEQGHPLLYSLTIMNNVLGGSMSSRLFQDVREKQGLAYAVFSYHSTFIDSGLLTIYG
HHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEC
GTGKEQLSVLEDTIQLTVDTLIQNGLTDKELRNSKEQLKGGLMLSLESTNSRMSRNGRNE
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHCCCEEEEEECCCHHHHCCCCHH
LLLKRHRTLDEMIQEIDAVSHETIQQVINEVFKEKAARALIAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]