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The map label for this gene is phoR [H]

Identifier: 23097813

GI number: 23097813

Start: 376865

End: 377866

Strand: Direct

Name: phoR [H]

Synonym: OB0358

Alternate gene names: 23097813

Gene position: 376865-377866 (Clockwise)

Preceding gene: 23097812

Following gene: 23097814

Centisome position: 10.38

GC content: 36.13

Gene sequence:

>1002_bases
ATGATAAGAAACAATGAGGTTCGGAGATATTTATTTTTTGCAATTACCATTCTCATAATTAGTACGGTTTCGATAGCATT
TATTTCGTCTGTTGCTGCTGGAATTGTTTTTGTATCGACTTCTCTAATTATTATTGTTTTTCTATGGATGACACACTGGC
GCTACAAACAAATGGAAAAACTCTCTCATTATTTAAGGCAAATATCAGCTGGAAATACTTCACTTGATGTACGGGATAAT
CGTGAAGGGGAGCTGAGCATATTAAAAAATGATATCTATAAAATGACTTTAATGCTTTCTGAGCAAGGGGAAGATCTAAA
AAAAGATAAACAAAAATTAACAGATGCTATCTCTGATATCTCGCATCAGCTAAAAACTCCTCTCACATCCATGACAGTTA
TGGCAGATTTACTTAGTGATGAGACGATGGATGATGAAAAGCGGTTGGAGTTCACGCATAATATCCGTAAACAACTGGAA
CGTATGGACTGGTTGGTATCTTCTTTGTTAAAGCTATCAAAAATGGATGCAGGTACTATTCCGTTTGCCATGGAACGAAT
TTTTGTATCTGATTTAATTGATGAAGTCATTGCTCCTTTAGAAATACCGATGGAACTAAAAGACATCGATTTCCAAAAGT
TTGGTAATAGAGAAGTGACTTTCTTAGGAGATTCCAATTGGACGAAAGAAGCGTTGATTAATATTATGAAAAATGCGATT
GAGCATACGCCTGAGGGTGAACATATTACCATACACTTTCAAGAGAACGCGCTTTATACAGAAATTATCGTACAAGATAC
AGGGAAGGGGATCCCAAAGCAAGACATTCCTTATATCTTTAAGCGATTTTATAAAGGCGGAAATGCCACGGATGGTAGCG
TAGGAATCGGATTAGCAATGGCACATAGCATTGTTACGAATCAGCAAGGCGATATTGAAGTCGTAAGTGAAGAAGGCAAG
GGAACAACGTTTACACTTAAATTCTATAAACAAGTTATTTAA

Upstream 100 bases:

>100_bases
GTATATATAAAGCGGCTAAGGAAAAAGATTGAAGAGGATGCACAACATCCAACAGTAATTGAGACTGTTCGTGGGATGGG
ATATAGGATGGTAGATACAC

Downstream 100 bases:

>100_bases
AAAGTAGAAGGTGACAATATTGTCACTGAAAAAGTCACTGAGCCGTCATGTTGGACAAGTATGCTAAAGATAAAGCAATA
GAAGGAGGAAATTTTACATG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIRNNEVRRYLFFAITILIISTVSIAFISSVAAGIVFVSTSLIIIVFLWMTHWRYKQMEKLSHYLRQISAGNTSLDVRDN
REGELSILKNDIYKMTLMLSEQGEDLKKDKQKLTDAISDISHQLKTPLTSMTVMADLLSDETMDDEKRLEFTHNIRKQLE
RMDWLVSSLLKLSKMDAGTIPFAMERIFVSDLIDEVIAPLEIPMELKDIDFQKFGNREVTFLGDSNWTKEALINIMKNAI
EHTPEGEHITIHFQENALYTEIIVQDTGKGIPKQDIPYIFKRFYKGGNATDGSVGIGLAMAHSIVTNQQGDIEVVSEEGK
GTTFTLKFYKQVI

Sequences:

>Translated_333_residues
MIRNNEVRRYLFFAITILIISTVSIAFISSVAAGIVFVSTSLIIIVFLWMTHWRYKQMEKLSHYLRQISAGNTSLDVRDN
REGELSILKNDIYKMTLMLSEQGEDLKKDKQKLTDAISDISHQLKTPLTSMTVMADLLSDETMDDEKRLEFTHNIRKQLE
RMDWLVSSLLKLSKMDAGTIPFAMERIFVSDLIDEVIAPLEIPMELKDIDFQKFGNREVTFLGDSNWTKEALINIMKNAI
EHTPEGEHITIHFQENALYTEIIVQDTGKGIPKQDIPYIFKRFYKGGNATDGSVGIGLAMAHSIVTNQQGDIEVVSEEGK
GTTFTLKFYKQVI
>Mature_333_residues
MIRNNEVRRYLFFAITILIISTVSIAFISSVAAGIVFVSTSLIIIVFLWMTHWRYKQMEKLSHYLRQISAGNTSLDVRDN
REGELSILKNDIYKMTLMLSEQGEDLKKDKQKLTDAISDISHQLKTPLTSMTVMADLLSDETMDDEKRLEFTHNIRKQLE
RMDWLVSSLLKLSKMDAGTIPFAMERIFVSDLIDEVIAPLEIPMELKDIDFQKFGNREVTFLGDSNWTKEALINIMKNAI
EHTPEGEHITIHFQENALYTEIIVQDTGKGIPKQDIPYIFKRFYKGGNATDGSVGIGLAMAHSIVTNQQGDIEVVSEEGK
GTTFTLKFYKQVI

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=256, Percent_Identity=27.734375, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786783, Length=289, Percent_Identity=24.9134948096886, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=26.1224489795918, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787374, Length=306, Percent_Identity=25.8169934640523, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=24.3150684931507, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=26.9709543568465, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=30.8943089430894, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=307, Percent_Identity=23.4527687296417, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=218, Percent_Identity=25.2293577981651, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786912, Length=261, Percent_Identity=22.9885057471264, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789149, Length=289, Percent_Identity=23.8754325259516, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788279, Length=241, Percent_Identity=24.896265560166, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=21.1678832116788, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790346, Length=212, Percent_Identity=28.7735849056604, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=24.537037037037, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37996; Mature: 37996

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNNEVRRYLFFAITILIISTVSIAFISSVAAGIVFVSTSLIIIVFLWMTHWRYKQMEK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHYLRQISAGNTSLDVRDNREGELSILKNDIYKMTLMLSEQGEDLKKDKQKLTDAISDI
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SHQLKTPLTSMTVMADLLSDETMDDEKRLEFTHNIRKQLERMDWLVSSLLKLSKMDAGTI
HHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PFAMERIFVSDLIDEVIAPLEIPMELKDIDFQKFGNREVTFLGDSNWTKEALINIMKNAI
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
EHTPEGEHITIHFQENALYTEIIVQDTGKGIPKQDIPYIFKRFYKGGNATDGSVGIGLAM
HCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
AHSIVTNQQGDIEVVSEEGKGTTFTLKFYKQVI
HHHHHHCCCCCEEEEECCCCCCEEEHHHHHHHC
>Mature Secondary Structure
MIRNNEVRRYLFFAITILIISTVSIAFISSVAAGIVFVSTSLIIIVFLWMTHWRYKQMEK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHYLRQISAGNTSLDVRDNREGELSILKNDIYKMTLMLSEQGEDLKKDKQKLTDAISDI
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SHQLKTPLTSMTVMADLLSDETMDDEKRLEFTHNIRKQLERMDWLVSSLLKLSKMDAGTI
HHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PFAMERIFVSDLIDEVIAPLEIPMELKDIDFQKFGNREVTFLGDSNWTKEALINIMKNAI
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
EHTPEGEHITIHFQENALYTEIIVQDTGKGIPKQDIPYIFKRFYKGGNATDGSVGIGLAM
HCCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
AHSIVTNQQGDIEVVSEEGKGTTFTLKFYKQVI
HHHHHHCCCCCEEEEECCCCCCEEEHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]