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The map label for this gene is lsrG

Identifier: 22127645

GI number: 22127645

Start: 4195130

End: 4195420

Strand: Direct

Name: lsrG

Synonym: y3774

Alternate gene names: 22127645

Gene position: 4195130-4195420 (Clockwise)

Preceding gene: 22127644

Following gene: 22127646

Centisome position: 91.18

GC content: 45.36

Gene sequence:

>291_bases
ATGCACGTTACTCTCGTCGAAATTAATGTAAAAGAGGACAAAGTTGATCAGTTCATTGAGGTTTTTCGCGCCAATCACCT
TGGGTCTATCCGCGAAGCGGGGAATTTACGTTTTGATGTGTTAAGGGACGAGCATATCCCGACGCGCTTTTATATTTACG
AAGCCTATACCGATGAAGCTGCGGTCGCCATTCATAAGACAACACCGCATTACTTACAGTGTGTCGAACAGTTGGCACCA
TTAATGACGGGGCCACGCAAAAAAACGGTATTTATCGGCCTAATGCCTTAG

Upstream 100 bases:

>100_bases
TGCGGCTTACCAACTGTTCCTCCATGAACAAAATTGAGTAGAACTGGCGGCCATCCGTGATTTTACCTACCGCTAATGGC
CCCATGACAAGGAGAAAAGT

Downstream 100 bases:

>100_bases
CTTGATTCCTTGGCTTAATGCTTTAGTCAATGCGGACCGCGATACCAATGTGTCGCGGCCCGGTTAAAATAGCGCCCTTT
ACGGAAGGTGTTGAACAGAT

Product: autoinducer-2 (AI-2) modifying protein LsrG

Products: NA

Alternate protein names: AI-2-degrading protein lsrG

Number of amino acids: Translated: 96; Mature: 96

Protein sequence:

>96_residues
MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEAAVAIHKTTPHYLQCVEQLAP
LMTGPRKKTVFIGLMP

Sequences:

>Translated_96_residues
MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEAAVAIHKTTPHYLQCVEQLAP
LMTGPRKKTVFIGLMP
>Mature_96_residues
MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEAAVAIHKTTPHYLQCVEQLAP
LMTGPRKKTVFIGLMP

Specific function: Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another

COG id: COG1359

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lsrG family

Homologues:

Organism=Escherichia coli, GI1787797, Length=96, Percent_Identity=75, Blast_Score=153, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSRG_YERP3 (A7FMK2)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402480.1
- ProteinModelPortal:   A7FMK2
- STRING:   A7FMK2
- GeneID:   5387777
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3526
- eggNOG:   COG1359
- HOGENOM:   HBG693987
- OMA:   KKTPHYL
- ProtClustDB:   PRK10486
- BioCyc:   YPSE349747:YPSIP31758_3526-MONOMER
- GO:   GO:0005737
- InterPro:   IPR007138
- InterPro:   IPR011008

Pfam domain/function: PF03992 ABM; SSF54909 Dimer_A_B_barrel

EC number: NA

Molecular weight: Translated: 11098; Mature: 11098

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEA
CEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHCCCEEEEEEECCCCCEEEEEEEEECCCE
AVAIHKTTPHYLQCVEQLAPLMTGPRKKTVFIGLMP
EEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MHVTLVEINVKEDKVDQFIEVFRANHLGSIREAGNLRFDVLRDEHIPTRFYIYEAYTDEA
CEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHCCCEEEEEEECCCCCEEEEEEEEECCCE
AVAIHKTTPHYLQCVEQLAPLMTGPRKKTVFIGLMP
EEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA