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The map label for this gene is murC [H]

Identifier: 22127499

GI number: 22127499

Start: 4017763

End: 4019286

Strand: Reverse

Name: murC [H]

Synonym: y3625

Alternate gene names: 22127499

Gene position: 4019286-4017763 (Counterclockwise)

Preceding gene: 22127500

Following gene: 22127498

Centisome position: 87.36

GC content: 51.51

Gene sequence:

>1524_bases
ATGAATGCAGGCTGTGAATACATGACAGACAAAAAAGTGAAGAGAAACGTGAATACACAACAACTGGCGAAACTGCGTAC
TATCGTGCCCGAGATGCGACGTGTCCGGCACATTCACTTTGTTGGCATCGGTGGTGCCGGCATGGGGGGTATCGCCGAAG
TGTTGGCCAACGAAGGTTATCAGATTAGTGGTTCAGATTTAGCACCCAACTCGGTAACTCAGCATTTGACTGCCCTGGGT
GCACAGATTTATTTCCATCATCGCCCGGAAAACGTGCTGGATGCGAGCGTGGTCGTGGTTTCTACTGCAATCTCTGCGGA
TAACCCAGAGATTGTCGCGGCCCGTGAGGCGAGAATACCGGTGATCCGCCGCGCAGAAATGTTGGCGGAATTGATGCGCT
ATCGCCATGGGATTGCCGTTGCTGGCACCCACGGCAAAACCACCACAACGGCGATGTTATCCAGTATTTATGCCGAAGCA
GGGTTAGATCCAACGTTCGTCAATGGTGGGTTAGTCAAGGCCGCGGGTACACATGCTCGTTTGGGTTCCAGCCGTTACCT
GATTGCAGAAGCCGATGAAAGCGACGCGTCATTCCTGCATTTGCAACCGATGGTGGCGATTGTTACCAATATCGAAGCCG
ATCATATGGATACCTACCAAGGCGACTTCGAAAATTTAAAACAGACATTCATTAACTTTTTGCACAATTTGCCCTTTTAT
GGCCGTGCGGTGATGTGTATCGATGATCCCGTAGTGCGTGAATTATTGCCACGTGTTGGCCGTCACATCACAACCTATGG
TTTCAGTGATGATGCTGATGTGCAGATCGCCAGCTATCGGCAAGAAGGCCCACAAGGGCACTTCACGTTGCGCCGTCAGG
ATAAACCGTTGATAGAGGTGACCTTGAATGCACCAGGTCGCCACAATGCACTGAATGCGGCGGCAGCAGTCGCTGTCGCA
ACAGAAGAAGGCATTGAAGACGAAGATATCCTGCGTGCATTAGTGGGTTTCCAAGGGACGGGGCGCCGTTTTGATTTCCT
CGGCAACTTCCCACTGGCCCCGGTTAACGGTAAAGAAGGCAGTGCGATGCTGGTTGATGATTATGGTCATCACCCTACCG
AAGTGGATGCCACCATTAAAGCCGCACGTGCTGGTTGGCCGGATAAACGCATTGTCATGCTCTTTCAGCCACACCGCTAT
ACCCGAACCCGCGATCTGTATGACGATTTCGCGAATGTGCTGTCACAGGTCGATGTTTTATTGATGCTGGATGTGTATGC
CGCAGGTGAGCCACCGATCCCAGGGGCAGATAGCCGCGCGTTGTGCCGAACGATTCGTAATCGCGGTAAGTTGGACCCTA
TTTTAGTGCCAGACAGCGAATCAGCACCTGAAATGTTGGCGCAAATACTGAACGGGGAAGACCTGATCTTGGTTCAGGGC
GCAGGTAACATTGGTAAAATTGCCCGTAAATTGGCTGAGCATAAATTGCAGCCACAGTTAAAAGACGAGGAACATCATGG
CTGA

Upstream 100 bases:

>100_bases
AGTCAGCGTAAAATCGCGATCACTTTGAAATAGCTACAATTTTAAATGGTTACGGTTTTGAAATAGCGATGACCTTGAAA
TAAACAGTGATCAGTGGGCG

Downstream 100 bases:

>100_bases
GAAAGTCGCGGTATTGCTGGGTGGGACCTCTGCGGAGCGTGAAGTGTCATTACTGTCAGGTCAGGCGGTATTGGCAGGCT
TGAAAGAAGCCGGTATCGAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MNAGCEYMTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALG
AQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEA
GLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFY
GRAVMCIDDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVA
TEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRY
TRTRDLYDDFANVLSQVDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQG
AGNIGKIARKLAEHKLQPQLKDEEHHG

Sequences:

>Translated_507_residues
MNAGCEYMTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALG
AQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEA
GLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFY
GRAVMCIDDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVA
TEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRY
TRTRDLYDDFANVLSQVDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQG
AGNIGKIARKLAEHKLQPQLKDEEHHG
>Mature_507_residues
MNAGCEYMTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALG
AQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEA
GLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFY
GRAVMCIDDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVA
TEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRY
TRTRDLYDDFANVLSQVDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQG
AGNIGKIARKLAEHKLQPQLKDEEHHG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=490, Percent_Identity=86.1224489795918, Blast_Score=795, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=27.2916666666667, Blast_Score=138, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 55493; Mature: 55493

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGCEYMTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGY
CCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCC
QISGSDLAPNSVTQHLTALGAQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIP
EECCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHEEEEEEEECCCCCCEEEECCCCCC
VIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAGTHAR
HHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHC
LGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFY
CCCCEEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GRAVMCIDDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEV
CEEEEEECCHHHHHHHHHHCCEEEECCCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEE
TLNAPGRHNALNAAAAVAVATEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEG
EECCCCCCCHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCC
SAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQVDVL
CEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQG
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEC
AGNIGKIARKLAEHKLQPQLKDEEHHG
CCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNAGCEYMTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGY
CCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCC
QISGSDLAPNSVTQHLTALGAQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIP
EECCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHEEEEEEEECCCCCCEEEECCCCCC
VIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAGTHAR
HHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHC
LGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFY
CCCCEEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GRAVMCIDDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEV
CEEEEEECCHHHHHHHHHHCCEEEECCCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEE
TLNAPGRHNALNAAAAVAVATEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEG
EECCCCCCCHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCC
SAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQVDVL
CEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
LMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQG
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEC
AGNIGKIARKLAEHKLQPQLKDEEHHG
CCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA