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The map label for this gene is iclR [H]

Identifier: 22123941

GI number: 22123941

Start: 24361

End: 24954

Strand: Reverse

Name: iclR [H]

Synonym: y0019

Alternate gene names: 22123941

Gene position: 24954-24361 (Counterclockwise)

Preceding gene: 22123943

Following gene: 22123940

Centisome position: 0.54

GC content: 53.7

Gene sequence:

>594_bases
ATGGACCATGGGGGCCCCCACGCCTTTATTGTCGGGAGCAGTTTCCTGCAAAGCCGTAATTTACTGGCGATGGTCCACCC
AATGTTACGCCGTTTAATGGATGAATCTGGCGAAACCGTCAATTTGGCGGTACTCGATCACAGCGATTACCAGGCAATAA
TTATCGATCAAGTGCAATGTACCGCGCTGATGCGGATGTCCGCACCAATTGGAGGCAAGCTCCCCATGCATGCCTCCGGG
GCAGGCAAAGCCTTTCTCTCCACCCTGCCGGACGATCAACTGGTTCAGTTGTTACATAAAAAGGGGTTGCACGCTTACAC
CCAGCACACCCGTACCAATCCAACCAGCCTGAAAGAAAATCTAGCGCTGATCCGCAAGCAAGGTTATTCATTTGATGATG
AAGAGCACGCCCTCGGCCTACGTTGTATCGCCGCCTGCTTGTTCGATGAGCACCACGAAGCCTTCGCCGCGATTTCTATC
TCCGGCCCAATATCACGGATCACCGACGATCGCGTCACCGAGCTGGGTGCACTGGTCATCCACGCGGCGAAAGAGATTAC
CCAATCTTACGGTGGGGGAACCGGGGTTAAATAA

Upstream 100 bases:

>100_bases
ATTTAGCCCAACAGGCGGGATTACCCAATTCGACCACCCACCGTTTACTCACGACCATGCAACAGCAGGGTTTTGTTCGT
CAGGTCGGCGATTTAGGGCT

Downstream 100 bases:

>100_bases
TAGAATGAAAAATAAAGGAAAAATTTGTCGTTCGGCGAGAACAGGCCGATCGTAAAGACGCGATAAATAGAGGCGTAGCG
AGCTACGTTAATCTGAGTAC

Product: acetate operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MDHGGPHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMHASG
AGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAAISI
SGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK

Sequences:

>Translated_197_residues
MDHGGPHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMHASG
AGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAAISI
SGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK
>Mature_197_residues
MDHGGPHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQCTALMRMSAPIGGKLPMHASG
AGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKENLALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAAISI
SGPISRITDDRVTELGALVIHAAKEITQSYGGGTGVK

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=188, Percent_Identity=78.1914893617021, Blast_Score=311, Evalue=2e-86,
Organism=Escherichia coli, GI1786715, Length=189, Percent_Identity=41.7989417989418, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1788131, Length=183, Percent_Identity=31.1475409836066, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788581, Length=176, Percent_Identity=30.6818181818182, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1786468, Length=161, Percent_Identity=29.1925465838509, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789999, Length=160, Percent_Identity=32.5, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1790752, Length=190, Percent_Identity=25.7894736842105, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 21380; Mature: 21380

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHGGPHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQC
CCCCCCEEEEECHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECHHHH
TALMRMSAPIGGKLPMHASGAGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKEN
HHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHHHHH
LALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAAISISGPISRITDDRVTELGALVI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHH
HAAKEITQSYGGGTGVK
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDHGGPHAFIVGSSFLQSRNLLAMVHPMLRRLMDESGETVNLAVLDHSDYQAIIIDQVQC
CCCCCCEEEEECHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECHHHH
TALMRMSAPIGGKLPMHASGAGKAFLSTLPDDQLVQLLHKKGLHAYTQHTRTNPTSLKEN
HHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHHHHH
LALIRKQGYSFDDEEHALGLRCIAACLFDEHHEAFAAISISGPISRITDDRVTELGALVI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHH
HAAKEITQSYGGGTGVK
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]