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The map label for this gene is tolC [H]

Identifier: 161484754

GI number: 161484754

Start: 3898575

End: 3899972

Strand: Direct

Name: tolC [H]

Synonym: y3516

Alternate gene names: 161484754

Gene position: 3898575-3899972 (Clockwise)

Preceding gene: 22127383

Following gene: 22127391

Centisome position: 84.74

GC content: 47.21

Gene sequence:

>1398_bases
ATGAAGAAACTGCTCCCCCTTCTTATCGGGCTGAGTCTGGCTGGTTTCAGCACCATGAGCCAGGCAGAGAACTTGCTGCA
AGTTTATAAGCAAGCCAGGGATAGTAACCCGGATTTACGTAAAGCCGCTGCTGATCGCGATGCCGCATATGAAAAAATCA
ATGAAGTACGCAGTCCACTGTTGCCACAACTTGGTTTAAGTGCCGGCTATACACATGCTAATGGATTTCGTGACGCGTCT
AACAGCCCAGATAGCAATGCCACATCAGGCTCTCTAAAACTGACCCAGACAATTTTTGACATGTCTAAATGGCGCGCCCT
GACCTTACAGGAAAAAGCGGCTGGGATTCAGGATGTGACATTCCAGACCAGCGAACAGCAACTGATTCTTAACACTGCAA
CGGCTTATTTCAACGTACTCAGAGCGATTGACAGCCTCTCTTATACTGAAGCGCAGAAACAATCGGTCTATCGTCAGTTG
GATCAAACAACTCAACGTTTTAATGTGGGTTTAGTGGCCATTACTGATGTGCAGAACGCCCGAGCCAGCTACGATACCGT
GTTAGCGGCAGAAGTGGCCGCCCGTAATAATCTGGATAACGCACTAGAGAGCTTGCGCCAGATTACTGGTGTTTATTATC
CCGAATTGGCGTCGTTGAATGTAGAACGATTGAAGACTCAACGCCCAGATGCGGTTAATAACCTATTGAAAGAAGCTGAA
AAACGTAACCTTTCTTTGCTTTCTGCCCGTTTGAGCCAAGACTTGGCACGTGAGCAAATTAAGTCTGCGGAAACGGGCTA
TATGCCAACCGTCGATTTGACCGCCTCATCTTCGATAACCAATACCCGTTACAGTGGCGGAACCCCCAGTTCTCAACAGG
TAAATAATGATTCCGGCCAGAACCAAATTGGCGTGCAATTTAGCTTACCGCTGTACAGCGGTGGTGCCACCAATTCTGCG
GTGAAACAAGCGCAGTATAATTTCGTTGGTGCCAGTGAGTTGTTGGAAAGTGCACATCGCAATATGGTGCAAACGCTTCG
CTCATCATTTAATAATATTTCAGCCTCGATCAGCAGCATCAATGCTTACCAGCAAGTGGTTATTTCTAACCAAAGCTCTT
TGGATGCAATGGAAGCTGGCTATCAGGTAGGCACCCGTACCATTCTGGATGTTTTGACTGCAACGACTAACCTGTATCAG
TCCAAACAACAATTGGCTGATGCTCGTTATAACTATTTAATCAATCAGTTAAATATCAAGTCGGCACTGGGGACGTTGAA
TATGAACGACCTGATGGCACTAAACGCCGTATTGGATAAACCGGTCCCGACGTCAGCGGCTGCTCTGGCACCAGAGAATA
CTACTCGCCAAACTGTCACTACACCACGCGCTCAGTAA

Upstream 100 bases:

>100_bases
CAATCGGCCACCTTATCCCATTGGCAGACTCTGATAGAATCGTCAACAATTCGTCTATCGACAGCTACCATGTAACATTG
CTGCACAACAAGGATTGCAA

Downstream 100 bases:

>100_bases
TCAGTAATAACCCACTCCGTCAGCGGTTTGGCTTCACCGGGCACAGTCATTGGCTGCGCCCGGTTTATTTTTTGCCTCCC
TCGATTTTACGACCAAACGT

Product: outer membrane channel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKAAADRDAAYEKINEVRSPLLPQLGLSAGYTHANGFRDAS
NSPDSNATSGSLKLTQTIFDMSKWRALTLQEKAAGIQDVTFQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQL
DQTTQRFNVGLVAITDVQNARASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQNQIGVQFSLPLYSGGATNSA
VKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSINAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQ
SKQQLADARYNYLINQLNIKSALGTLNMNDLMALNAVLDKPVPTSAAALAPENTTRQTVTTPRAQ

Sequences:

>Translated_465_residues
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKAAADRDAAYEKINEVRSPLLPQLGLSAGYTHANGFRDAS
NSPDSNATSGSLKLTQTIFDMSKWRALTLQEKAAGIQDVTFQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQL
DQTTQRFNVGLVAITDVQNARASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQNQIGVQFSLPLYSGGATNSA
VKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSINAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQ
SKQQLADARYNYLINQLNIKSALGTLNMNDLMALNAVLDKPVPTSAAALAPENTTRQTVTTPRAQ
>Mature_465_residues
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKAAADRDAAYEKINEVRSPLLPQLGLSAGYTHANGFRDAS
NSPDSNATSGSLKLTQTIFDMSKWRALTLQEKAAGIQDVTFQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQL
DQTTQRFNVGLVAITDVQNARASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQNQIGVQFSLPLYSGGATNSA
VKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSINAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQ
SKQQLADARYNYLINQLNIKSALGTLNMNDLMALNAVLDKPVPTSAAALAPENTTRQTVTTPRAQ

Specific function: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=456, Percent_Identity=75.219298245614, Blast_Score=665, Evalue=0.0,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50674; Mature: 50674

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKAAADRDAAYEKINEVRSPL
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
LPQLGLSAGYTHANGFRDASNSPDSNATSGSLKLTQTIFDMSKWRALTLQEKAAGIQDVT
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQLDQTTQRFNVGLVAITDVQNA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
RASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHH
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
NQIGVQFSLPLYSGGATNSAVKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSI
CEEEEEEECCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQSKQQLADARYNYLINQLNIK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALGTLNMNDLMALNAVLDKPVPTSAAALAPENTTRQTVTTPRAQ
HHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLLPLLIGLSLAGFSTMSQAENLLQVYKQARDSNPDLRKAAADRDAAYEKINEVRSPL
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
LPQLGLSAGYTHANGFRDASNSPDSNATSGSLKLTQTIFDMSKWRALTLQEKAAGIQDVT
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FQTSEQQLILNTATAYFNVLRAIDSLSYTEAQKQSVYRQLDQTTQRFNVGLVAITDVQNA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
RASYDTVLAAEVAARNNLDNALESLRQITGVYYPELASLNVERLKTQRPDAVNNLLKEAE
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHH
KRNLSLLSARLSQDLAREQIKSAETGYMPTVDLTASSSITNTRYSGGTPSSQQVNNDSGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
NQIGVQFSLPLYSGGATNSAVKQAQYNFVGASELLESAHRNMVQTLRSSFNNISASISSI
CEEEEEEECCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAYQQVVISNQSSLDAMEAGYQVGTRTILDVLTATTNLYQSKQQLADARYNYLINQLNIK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALGTLNMNDLMALNAVLDKPVPTSAAALAPENTTRQTVTTPRAQ
HHHCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8801424 [H]