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The map label for this gene is aroB [H]

Identifier: 21910816

GI number: 21910816

Start: 1284353

End: 1285426

Strand: Direct

Name: aroB [H]

Synonym: SpyM3_1280

Alternate gene names: 21910816

Gene position: 1284353-1285426 (Clockwise)

Preceding gene: 21910815

Following gene: 21910828

Centisome position: 67.58

GC content: 42.27

Gene sequence:

>1074_bases
ATGCCACAAACACTTCATGTCCATTCTCGGGTCAAGGATTATGATATCCTGTTTACCGACCATGTTTTAAAAACCTTAGC
AGATTGCCTTGGTGAGCGCAAGCAGCGTAAACTCTTGTTTATCACCGATCAAACGGTCTACCACTTGTATCAGACTCTCT
TTGAAGAATTTGCTCAGCAATACAACGCTTTTGTCCATGTCTACCCCTCGGGAGGTCAATCCAAATCCTTGGAACGTGTC
AGTGCTATCTACGACCAGCTCATCGCTGAAAATTTTTCCAAAAAAGATATGATTGTTACTATTGGTGGTGGTGTTGTTGG
GGATCTGGGTGGTTTTGTCGCTGCAACCTATTACCGTGGTATTCCCTACATTCAAATCCCAACGACTTTACTTAGTCAGG
TGGACAGCAGTATCGGGGGCAAAGTTGGAGTCCATTTTAAAGGTCTAACCAATATGATTGGCAGCATTTACCCTCCAGAA
GCTATCATTATTTCAACCACCTTTTTGGAGACCTTACCGCAACGGGAATTCTCCTGCGGCATCAGTGAGATGCTCAAAAT
AGGCTTCATTCATGATAGACCGCTTTTTCAGCAGTTACGTGATTTTCAAAAAGAAACCGATAAGCAGGGACTTGAACGTC
TGATTTACCAATCCATTTCCAATAAAAAACGGATTGTTGAACAAGATGAATTTGAAAATGGTTTGCGCATGTCTTTAAAT
TTTGGGCATACCTTGGGCCACGCGATTGAATCGCTCTGCCACCATGATTTTTACCATCACGGTGAAGCCATTGCTATCGG
TATGGTGGTTGATGCTAAACTGGCTGTTTCCAAAGGGCTCTTGCCAAAAGAGGACTTGGATAGCCTCCTTCAAGTTTTTG
AACGTTACCAGTTACCAACAACACTTGAAAGAGCTGATGTCTCTGCGACATCCCTCTTTGACGTCTTTAAAACAGATAAG
AAGAATTCTGAGCAACATATTATCTTTATATTACCCACAGAAACCGGTTTTACCACCCTAGCCATTAACAAAGACGATCA
CCAATTTGTCGAGAAGCTCGACAGTTTATTATAA

Upstream 100 bases:

>100_bases
TATAAGCAATTAGAACAGTTGGGGCAGGAACTTTGGCAAGATTAAGCTCTAAATATCACTGCGTTATCTCTGTTACCTAG
TACTGATGAAAGGAGTGCTT

Downstream 100 bases:

>100_bases
ATAGTGACTCCACTCTAGCTAGTTAAGCTTGCTAAGAGAATAACGGTATCCTGGAACTCCTAAAACATGTTACTACAAGA
CAAGTCTTGATAACAATATA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQYNAFVHVYPSGGQSKSLERV
SAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKGLTNMIGSIYPPE
AIIISTTFLETLPQREFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGLRMSLN
FGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPTTLERADVSATSLFDVFKTDK
KNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL

Sequences:

>Translated_357_residues
MPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQYNAFVHVYPSGGQSKSLERV
SAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKGLTNMIGSIYPPE
AIIISTTFLETLPQREFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGLRMSLN
FGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPTTLERADVSATSLFDVFKTDK
KNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL
>Mature_356_residues
PQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQYNAFVHVYPSGGQSKSLERVS
AIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKGLTNMIGSIYPPEA
IIISTTFLETLPQREFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGLRMSLNF
GHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPTTLERADVSATSLFDVFKTDKK
NSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789791, Length=330, Percent_Identity=34.5454545454545, Blast_Score=178, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6320332, Length=286, Percent_Identity=33.5664335664336, Blast_Score=155, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037 [H]

Pfam domain/function: PF01761 DHQ_synthase [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 40410; Mature: 40279

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQ
CCCCEEHHHCCCCHHEEHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHH
YNAFVHVYPSGGQSKSLERVSAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRG
CCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
IPYIQIPTTLLSQVDSSIGGKVGVHFKGLTNMIGSIYPPEAIIISTTFLETLPQREFSCG
CCEEEEHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEEEEEHHHHHHHCCHHHHCC
ISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGLRMSLN
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCEEEEE
FGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPT
CCHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
TLERADVSATSLFDVFKTDKKNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL
HHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
PQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQ
CCCEEHHHCCCCHHEEHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHH
YNAFVHVYPSGGQSKSLERVSAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRG
CCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
IPYIQIPTTLLSQVDSSIGGKVGVHFKGLTNMIGSIYPPEAIIISTTFLETLPQREFSCG
CCEEEEHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEEEEEHHHHHHHCCHHHHCC
ISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGLRMSLN
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCEEEEE
FGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPT
CCHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
TLERADVSATSLFDVFKTDKKNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL
HHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]